> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/target/hck-a6e579ec-a0ce-5a92-852f-b885e3d6f42a
> Record changed: 2026-11-04

# HCK

ENSG00000101336

Target class

Kinase

Chromosome

20

Approved drugs

2

Clinical candidates (approved and in development)

6

## Clinical evidence

**Approved drugs**

2

**Clinical candidates (approved and in development)**

6

## Druggability

**Chemical probe available**

Yes

## Names

**Other names**

- JTK9

**Target name**

HCK

**Gene name**

HCK proto-oncogene, Src family tyrosine kinase

**Gene symbol**

HCK

**Protein name**

Tyrosine-protein kinase HCK (EC 2.7.10.2) (Hematopoietic cell kinase) (Hemopoietic cell kinase) (p59-HCK/p60-HCK) (p59Hck) (p61Hck)

## Classification

**Gene biotype**

Protein coding

**Gene family**

SH2 domain containing|Src family tyrosine kinases

**Target class**

Kinase

**Target type**

Human gene

## Expression and localisation

**Tissues expressed in**

53

**Protein localisation evidence grade**

Supported

**Highest tissue expression**

545.06

**Tissue specificity (Gini)**

0.785

**Tissue specificity (tau)**

0.981

## Pathways and interactions

**KEGG gene identifiers**

- hsa:3055

**Protein interaction confidence**

0.836857

**Protein interaction partners**

70

### Reactome pathways (9)

- R-HSA-164944
- R-HSA-2029481
- R-HSA-912631
- R-HSA-9664323
- R-HSA-9664422
- R-HSA-9674555
- R-HSA-9680350
- R-HSA-9705462
- R-HSA-9706374

## Genomic location

**End position**

32101856

**Start position**

32052197

**Chromosome**

20

**Strand**

Forward

## Identifiers

**Ensembl gene ID**

ENSG00000101336

**HGNC ID**

HGNC:4840

Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:4840)

**NCBI Gene ID**

3055

**UniProt ID**

P08631

## Cellular location

- \[Isoform 1\]: Lysosome. Membrane
- Lipid-anchor. Cell projection, podosome membrane
- Lipid-anchor. Cytoplasm, cytosol. Note=Associated with specialized secretory lysosomes called azurophil granules. At least half of this isoform is found in the cytoplasm, some of this fraction is myristoylated.
- SUBCELLULAR LOCATION: \[Isoform 2\]: Cell membrane
- Lipid-anchor . Membrane, caveola
- Lipid-anchor . Cell junction, focal adhesion . Cytoplasm, cytoskeleton . Golgi apparatus . Cytoplasmic vesicle . Lysosome . Nucleus . Note=20% of this isoform is associated with caveolae. Localization at the cell membrane and at caveolae requires palmitoylation at Cys-3\. Colocalizes with the actin cytoskeleton at focal adhesions.
- SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle. Cytoplasm, cytosol.
- Cytosol
- Plasma membrane
- Vesicles

### Publication evidence

- PubMed 11904303  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/11904303/)

## Tissue expression

**Tissue specificity (tau)**

0.98098

**Expression inequality (Gini)**

0.784869

### Highest expression

Expression in transcripts per million

**Whole Blood**

545.06

**Spleen**

182.77

**Lung**

60.42

**Adipose - Visceral (Omentum)**

18.98

**Small Intestine - Terminal Ileum**

18.1

### All tissues (54)

Expression in transcripts per million

- Whole Blood545.06
- Spleen182.77
- Lung60.42
- Adipose - Visceral (Omentum)18.98
- Small Intestine - Terminal Ileum18.1
- Adipose - Subcutaneous16.18
- Cells - EBV-transformed lymphocytes14.94
- Artery - Coronary13.54
- Artery - Aorta12.77
- Nerve - Tibial12.5
- Brain - Spinal cord (cervical c-1)10.73
- Adrenal Gland10.49
- Colon - Transverse10.43
- Bladder9.03
- Breast - Mammary Tissue8.73
- Fallopian Tube7.98
- Cervix - Endocervix7.49
- Prostate6.53
- Vagina6.52
- Colon - Sigmoid6.17
- Minor Salivary Gland5.92
- Esophagus - Muscularis5.77
- Artery - Tibial5.54
- Skin - Sun Exposed (Lower leg)5.3
- Brain - Substantia nigra5.26

And 29 more, listed on the interactive page.

## Biological functions

### Biological processes (24)

- GO:0002522  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0002522)
- GO:0002758  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0002758)
- GO:0002862  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0002862)
- GO:0006468  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006468)
- GO:0007155  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007155)
- GO:0007229  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007229)
- GO:0007498  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007498)
- GO:0008284  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008284)
- GO:0008360  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008360)
- GO:0018108  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0018108)
- GO:0019221  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0019221)
- GO:0030838  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030838)
- GO:0031663  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0031663)
- GO:0032956  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032956)
- GO:0035556  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0035556)
- GO:0038096  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0038096)
- GO:0043066  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043066)
- GO:0043299  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043299)
- GO:0045728  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045728)
- GO:0046777  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0046777)
- GO:0050727  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0050727)
- GO:0050764  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0050764)
- GO:0060333  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0060333)
- GO:0071801  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0071801)

### Cellular components (7)

- GO:0005764  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005764)
- GO:0005829  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005829)
- GO:0005884  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005884)
- GO:0005886  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886)
- GO:0005901  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005901)
- GO:0005925  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005925)
- GO:0009898  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0009898)

### Molecular functions (4)

- GO:0001784  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0001784)
- GO:0004713  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004713)
- GO:0005515  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515)
- GO:0008289  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008289)

## Related records

### Trials (750)

- A Bioequivalence Study of Dasatinib Tablet
- A Clinical Trial Evaluating the Efficacy and Safety of Dasatinib in Refractory Metastatic GIST
- A Clinical Trial of Buparlisib and Ibrutinib in Lymphoma
- A Crossover Study to Evaluate the Bioavailability of Ibrutinib Suspension and Sprinkle Formulations Compared to Capsules in Healthy Adults
- A Dose Escalation and Expansion Study Evaluating the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of RO7283420.
- A Drug Interaction Study Between Bosutinib And Aprepitant In Healthy Volunteers
- A Drug Interaction Study to Assess the Effect of Omeprazole on the Pharmacokinetics of Ibrutinib in Healthy Adults
- A Long-term Extension Study of PCI-32765 (Ibrutinib)
- A Multi-Center Study of Ibrutinib in Combination With MEDI4736 in Subjects With Relapsed or Refractory Lymphomas
- A Multi-Center Study of Ibrutinib in Combination With MEDI4736 in Subjects With Relapsed or Refractory Solid Tumors
- A Multi-Center Study of Ibrutinib in Combination With Obinutuzumab Versus Chlorambucil in Combination With Obinutuzumab in Patients With Treatment naïve Chronic Lymphocytic Leukemia (CLL) or Small Lymphocytic Lymphoma (SLL)
- A Multicenter Phase 2 Study of Ibrutinib in Patients With Relapsed or Refractory Chronic Lymphocytic Leukemia (CLL) or Small Lymphocytic Lymphoma (SLL) With 17p Deletion
- A Multicenter Phase 3, Open-Label Study of Bosutinib Versus Imatinib in Adult Patients With Newly Diagnosed Chronic Phase Chronic Myelogenous Leukemia
- A Pharmacokinetic Study in Healthy Participants to Assess the Pharmacokinetics and Safety of a Supratherapeutic Dose of PCI-32765 (Ibrutinib) Capsule and Solution Formulations Administered With Food
- A Phase 1 Safety Study of TG100801 Eye Drops in Healthy Volunteers
- A Phase 1 Study of MKC-1 in Patients With Refractory Hematologic Malignancies
- A Phase 1/2, Open-label, Dose Finding Study to Evaluate CC-122 in Combination With Ibrutinib and Obinutuzumab in Subjects With Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma
- A Phase 1B Study to Investigate the Safety and Preliminary Efficacy for the Combination of Dasatinib Plus Nivolumab in Patients With Chronic Myeloid Leukemia
- A Phase 2 Study of Oral MKC-1 in Patients With Ovarian or Endometrial Cancer
- A Phase 3 Study of Ibrutinib (PCI-32765) Versus Ofatumumab in Patients With Relapsed or Refractory Chronic Lymphocytic Leukemia

### Drugs (10)

- Bosutinib Tyrosine-protein kinase HCK inhibitor
- Dasatinib
- Dasatinib anhydrous SRC inhibitor
- Dasatinib laurylsulfate SRC inhibitor
- ENMD-981693 SRC inhibitor
- [Ibrutinib](https://trialight.com/data/asset/ibrutinib-0b3ac4fd-6e98-4847-a711-2f599e8bb93d.md)
- Ilorasertib SRC inhibitor
- Pexmetinib
- TG100-801 SRC inhibitor
- XL-228 SRC inhibitor

---

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