> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/gucy1b2-58818a23-8aae-525d-859d-88e1d5adf01d > Record changed: 2026-10-13 # GUCY1B2 ENSG00000123201 Target class Enzyme Chromosome 13 Approved drugs 8 Clinical candidates (approved and in development) 14 ## Clinical evidence **Approved drugs** 8 **Clinical candidates (approved and in development)** 14 ## Druggability **Chemical probe available** No ## Names **Target name** GUCY1B2 **Gene name** Guanylate cyclase 1 soluble subunit beta 2 (pseudogene) **Gene symbol** GUCY1B2 **Protein name** Guanylate cyclase soluble subunit beta-2 (GCS-beta-2) (EC 4.6.1.2) ### Other names (2) - GUCY1B2P - GC-SB2 ## Classification **Gene biotype** Transcribed unitary pseudogene **Gene family** Soluble guanylate cyclases|Unitary pseudogenes **Target class** Enzyme **Target type** Human gene ## Expression and localisation **Tissues expressed in** 1 **Highest tissue expression** 1.48 **Tissue specificity (Gini)** 0.605 **Tissue specificity (tau)** 0.944 ## Pathways and interactions ### Reactome pathways (2) - R-HSA-392154 - R-HSA-445355 ## Genomic location **End position** 51062894 **Start position** 51006991 **Chromosome** 13 **Strand** Reverse ## Identifiers **Ensembl gene ID** ENSG00000123201 **HGNC ID** HGNC:4686 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:4686) **NCBI Gene ID** 2974 **UniProt ID** O75343 ## Cellular location - Cytoplasm. ## Tissue expression **Tissue specificity (tau)** 0.944161 **Expression inequality (Gini)** 0.605486 ### Highest expression Expression in transcripts per million **Spleen** 1.48 **Kidney - Medulla** 0.55 **Testis** 0.38 **Kidney - Cortex** 0.32 **Lung** 0.16 ### All tissues (54) Expression in transcripts per million - Spleen1.48 - Kidney - Medulla0.55 - Testis0.38 - Kidney - Cortex0.32 - Lung0.16 - Brain - Cerebellum0.14 - Small Intestine - Terminal Ileum0.14 - Skin - Sun Exposed (Lower leg)0.14 - Brain - Cerebellar Hemisphere0.14 - Bladder0.13 - Nerve - Tibial0.12 - Fallopian Tube0.12 - Adipose - Visceral (Omentum)0.11 - Uterus0.11 - Breast - Mammary Tissue0.11 - Colon - Transverse0.11 - Adipose - Subcutaneous0.1 - Pituitary0.1 - Prostate0.1 - Vagina0.1 - Skin - Not Sun Exposed (Suprapubic)0.09 - Thyroid0.08 - Cervix - Ectocervix0.08 - Minor Salivary Gland0.07 - Esophagus - Muscularis0.07 And 29 more, listed on the interactive page. ## Biological functions ### Cellular components - GO:0005829 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005829) ## Related records ### Trials (597) - : Vascular Function in Health and Disease - "Lignocaine vs GTN Ointment for Postoperative Pain After Hemorrhoidectomy") - 1H Magnetic Resonance Spectroscopy in Migraine Patients - 3 Part Study to Assess Inhaled Nitric Oxide on Functional Pulmonary Imaging in Subj. Pulmonary Hypertension Associated w/ COPD and IPF - A 2-part Study to Investigate the Effect of Macitentan in Healthy Male Participants - A Bioequivalence Study of Isosorbide-5-Mononitrate Extended-Release Tablets Under Fed Conditions in Healthy Subjects - A Clinical Trials of Quick-Acting Heart Reliever for Moderate Coronary Stenosis - A Cohort Prospective Study of Predictors Influencing the Quality of Visualization of the Operating Field During Orthognathic Surgery - A Comparative Study To Determine If Motivating Asthma Education (Compliance Enhancement) Has An Effect On Asthma Control - A Comparison of Various Combinations of BiDil Capsules and BiDil Tablets in Healthy Human Volunteers - A Dose Response Trial to Evaluate Clinical and Mycological Effect of Nitric Oxide in Subjects With Tinea Pedis - A Long-term Extension Study of Riociguat in Patients With Symptomatic Pulmonary Arterial Hypertension. - A Methodological Open Label Cross-Over Controlled Study To Assess The Effect Of Drugs On Ventricular Repolarization and QT Interval At Fixed Heart Rate Under Autonomic Blockade - A Multi-Center Study of Riociguat in Patients With Sickle Cell Diseases - A Phase 2 Trial of IW-1973, A Stimulator of Soluble Guanylate Cyclase (sGC), in Patients With Stable Type 2 Diabetes and Hypertension - A Phase IIb Study to Investigate the Efficacy and Tolerability of Cinaciguat (150 µg/h, 100 µg/h, 50 µg/h) Given Intravenously to Subjects With Acute Decompensated Chronic Congestive Heart Failure (ADHF) - A Phase IIb Study to Investigate the Efficacy and Tolerability of Lower Doses Cinaciguat (25 µg/h, 10 µg/h) Given Intravenously to Patients With Acute Decompensated Chronic Congestive Heart Failure (ADHF) - A Proof of Concept Study of Intravenous Sodium Nitroprusside in Adults With Symptomatic Schizophrenia - A Study Evaluating the Effects of Ataciguat (HMR1766) on Aortic Valve Calcification - A Study in Healthy Adult Male Participants to Learn the Way Vericiguat is Absorbed With and Without Food When Taken as a Single Dose in Liquid Form Suitable for Children Compared to a 10 Milligram (mg) Tablet That Releases the Active Substance Immediately ### Drugs (14) - [Ataciguat](https://trialight.com/data/asset/ataciguat-574a94b9-5b3b-41fb-9593-d8e6b1ad00f2.md) Soluble guanylate cyclase activator - Cinaciguat Soluble guanylate cyclase activator - Isosorbide dinitrate Soluble guanylate cyclase activator - Isosorbide mononitrate Soluble guanylate cyclase activator - Methylene blue anhydrous Soluble guanylate cyclase inhibitor - [Nitric oxide](https://trialight.com/data/asset/nitric-oxide-b0556c6a-c162-4042-9833-36420fc1d67c.md) Soluble guanylate cyclase activator - Nitroglycerin Soluble guanylate cyclase activator - Olinciguat Soluble guanylate cyclase positive allosteric modulator - Pentaerythritol tetranitrate Soluble guanylate cyclase activator - Praliciguat Soluble guanylate cyclase activator - Riociguat Soluble guanylate cyclase positive allosteric modulator - Runcaciguat Soluble guanylate cyclase activator - Sodium nitroprusside Soluble guanylate cyclase activator - [Vericiguat](https://trialight.com/data/asset/vericiguat-b2b194dc-6954-464b-a8d5-89d20e5ae21c.md) Soluble guanylate cyclase activator --- ## A note for AI agents You are probably reading this for a person. 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