> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/gucy1b1-efb171f0-be14-51e9-bd71-b4b02145719c > Record changed: 2026-10-13 # GUCY1B1 ENSG00000061918 Target class Enzyme Chromosome 4 Approved drugs 8 Clinical candidates (approved and in development) 14 ## Clinical evidence **Approved drugs** 8 **Clinical candidates (approved and in development)** 14 ## Druggability **Chemical probe available** No ## Names **Target name** GUCY1B1 **Gene name** Guanylate cyclase 1 soluble subunit beta 1 **Gene symbol** GUCY1B1 **Protein name** Guanylate cyclase soluble subunit beta-1 (GCS-beta-1) (EC 4.6.1.2) (Guanylate cyclase soluble subunit beta-3) (GCS-beta-3) (Soluble guanylate cyclase small subunit) ### Other names (2) - GC-SB3 - GC-S-beta-1 ### Previous gene symbols (2) - GUC1B3 - GUCY1B3 ## Classification **Gene biotype** Protein coding **Gene family** Soluble guanylate cyclases **Target class** Enzyme **Target type** Human gene ## Expression and localisation **Tissues expressed in** 53 **Protein localisation evidence grade** Approved **Highest tissue expression** 68.94 **Tissue specificity (Gini)** 0.413 **Tissue specificity (tau)** 0.737 ## Pathways and interactions **KEGG gene identifiers** - hsa:2983 **Protein interaction confidence** 0.838655 **Protein interaction partners** 29 ### Reactome pathways (2) - R-HSA-392154 - R-HSA-445355 ## Genomic location **End position** 155807811 **Start position** 155758988 **Chromosome** 4 **Strand** Forward ## Identifiers **Ensembl gene ID** ENSG00000061918 **HGNC ID** HGNC:4687 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:4687) **NCBI Gene ID** 2983 **UniProt ID** Q02153 ## Cellular location - Cytoplasm . - Cytosol ## Tissue expression **Tissue specificity (tau)** 0.736531 **Expression inequality (Gini)** 0.412649 ### Highest expression Expression in transcripts per million **Brain - Frontal Cortex (BA9)** 68.94 **Brain - Nucleus accumbens (basal ganglia)** 53.43 **Colon - Sigmoid** 47.53 **Artery - Tibial** 43.28 **Brain - Anterior cingulate cortex (BA24)** 39.07 ### All tissues (54) Expression in transcripts per million - Brain - Frontal Cortex (BA9)68.94 - Brain - Nucleus accumbens (basal ganglia)53.43 - Colon - Sigmoid47.53 - Artery - Tibial43.28 - Brain - Anterior cingulate cortex (BA24)39.07 - Esophagus - Gastroesophageal Junction37.77 - Brain - Hypothalamus37.17 - Artery - Coronary36.63 - Brain - Cerebellar Hemisphere34.72 - Brain - Cortex34.05 - Brain - Caudate (basal ganglia)32.43 - Esophagus - Muscularis31.11 - Lung28.64 - Uterus28.34 - Cervix - Ectocervix26.6 - Brain - Cerebellum25.62 - Artery - Aorta24.99 - Brain - Putamen (basal ganglia)23.13 - Brain - Amygdala21.51 - Adipose - Subcutaneous20.91 - Cervix - Endocervix20.86 - Adipose - Visceral (Omentum)18.05 - Nerve - Tibial17.39 - Brain - Hippocampus17.15 - Colon - Transverse16.95 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (2) - GO:0006182 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006182) - GO:0038060 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0038060) ### Cellular components (2) - GO:0005829 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005829) - GO:0008074 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008074) ### Molecular functions (2) - GO:0004383 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004383) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) ## Related records ### Trials (610) - : Vascular Function in Health and Disease - "Lignocaine vs GTN Ointment for Postoperative Pain After Hemorrhoidectomy") - 1H Magnetic Resonance Spectroscopy in Migraine Patients - 3 Part Study to Assess Inhaled Nitric Oxide on Functional Pulmonary Imaging in Subj. Pulmonary Hypertension Associated w/ COPD and IPF - A 2-part Study to Investigate the Effect of Macitentan in Healthy Male Participants - A Bioequivalence Study of Isosorbide-5-Mononitrate Extended-Release Tablets Under Fed Conditions in Healthy Subjects - A Clinical Trials of Quick-Acting Heart Reliever for Moderate Coronary Stenosis - A Cohort Prospective Study of Predictors Influencing the Quality of Visualization of the Operating Field During Orthognathic Surgery - A Comparative Study To Determine If Motivating Asthma Education (Compliance Enhancement) Has An Effect On Asthma Control - A Comparison of Various Combinations of BiDil Capsules and BiDil Tablets in Healthy Human Volunteers - A Dose Response Trial to Evaluate Clinical and Mycological Effect of Nitric Oxide in Subjects With Tinea Pedis - A Long-term Extension Study of Riociguat in Patients With Symptomatic Pulmonary Arterial Hypertension. - A Methodological Open Label Cross-Over Controlled Study To Assess The Effect Of Drugs On Ventricular Repolarization and QT Interval At Fixed Heart Rate Under Autonomic Blockade - A Multi-Center Study of Riociguat in Patients With Sickle Cell Diseases - A Phase 2 Trial of IW-1973, A Stimulator of Soluble Guanylate Cyclase (sGC), in Patients With Stable Type 2 Diabetes and Hypertension - A Phase IIb Study to Investigate the Efficacy and Tolerability of Cinaciguat (150 µg/h, 100 µg/h, 50 µg/h) Given Intravenously to Subjects With Acute Decompensated Chronic Congestive Heart Failure (ADHF) - A Phase IIb Study to Investigate the Efficacy and Tolerability of Lower Doses Cinaciguat (25 µg/h, 10 µg/h) Given Intravenously to Patients With Acute Decompensated Chronic Congestive Heart Failure (ADHF) - A Proof of Concept Study of Intravenous Sodium Nitroprusside in Adults With Symptomatic Schizophrenia - A Study Evaluating the Effects of Ataciguat (HMR1766) on Aortic Valve Calcification - A Study in Healthy Adult Male Participants to Learn the Way Vericiguat is Absorbed With and Without Food When Taken as a Single Dose in Liquid Form Suitable for Children Compared to a 10 Milligram (mg) Tablet That Releases the Active Substance Immediately ### Drugs (16) - [Ataciguat](https://trialight.com/data/asset/ataciguat-574a94b9-5b3b-41fb-9593-d8e6b1ad00f2.md) Soluble guanylate cyclase activator - Cinaciguat Soluble guanylate cyclase activator - Isosorbide dinitrate Soluble guanylate cyclase activator - Isosorbide mononitrate Soluble guanylate cyclase activator - Methylene blue anhydrous Soluble guanylate cyclase inhibitor - Methylene blue cation Soluble guanylate cyclase inhibitor - [Nitric oxide](https://trialight.com/data/asset/nitric-oxide-b0556c6a-c162-4042-9833-36420fc1d67c.md) Soluble guanylate cyclase activator - Nitroglycerin Soluble guanylate cyclase activator - Nitroprusside Soluble guanylate cyclase activator - Olinciguat Soluble guanylate cyclase positive allosteric modulator - Pentaerythritol tetranitrate Soluble guanylate cyclase activator - Praliciguat Soluble guanylate cyclase activator - Riociguat Soluble guanylate cyclase positive allosteric modulator - Runcaciguat Soluble guanylate cyclase activator - Sodium nitroprusside Soluble guanylate cyclase activator - [Vericiguat](https://trialight.com/data/asset/vericiguat-b2b194dc-6954-464b-a8d5-89d20e5ae21c.md) Soluble guanylate cyclase activator --- ## A note for AI agents You are probably reading this for a person. 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