> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/gpr18-05356393-ebec-5cf1-b9b4-c5d0f904e51a > Record changed: 2026-11-04 # GPR18 ENSG00000125245 Target class GPCR Chromosome 13 ## Druggability **Chemical probe available** No ## Names **Other names** - DRV2 **Target name** GPR18 **Gene name** G protein-coupled receptor 18 **Gene symbol** GPR18 **Protein name** N-arachidonyl glycine receptor (NAGly receptor) (G-protein coupled receptor 18) ## Classification **Gene biotype** Protein coding **Gene family** G protein-coupled receptors, Class A orphans **Target class** GPCR **Target type** Human gene ## Expression and localisation **Tissues expressed in** 5 **Highest tissue expression** 22.53 **Tissue specificity (Gini)** 0.806 **Tissue specificity (tau)** 0.975 ## Pathways and interactions **KEGG gene identifiers** - hsa:2841 **Protein interaction confidence** 0.778125 **Protein interaction partners** 8 ### Reactome pathways (2) - R-HSA-373076 - R-HSA-418594 ## Genomic location **End position** 99261744 **Start position** 99254732 **Chromosome** 13 **Strand** Reverse ## Identifiers **Ensembl gene ID** ENSG00000125245 **HGNC ID** HGNC:4472 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:4472) **NCBI Gene ID** 2841 **UniProt ID** Q14330 ## Cellular location - Cell membrane - Multi-pass membrane protein . Cytoplasmic vesicle membrane . ### Publication evidence (2) - PubMed 24762058 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/24762058/) - PubMed 27018161 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/27018161/) ## Tissue expression **Tissue specificity (tau)** 0.974525 **Expression inequality (Gini)** 0.806425 ### Highest expression Expression in transcripts per million **Testis** 22.53 **Spleen** 10.89 **Whole Blood** 3.14 **Cells - EBV-transformed lymphocytes** 2.95 **Small Intestine - Terminal Ileum** 1.9 ### All tissues (54) Expression in transcripts per million - Testis22.53 - Spleen10.89 - Whole Blood3.14 - Cells - EBV-transformed lymphocytes2.95 - Small Intestine - Terminal Ileum1.9 - Lung0.78 - Cervix - Ectocervix0.62 - Prostate0.62 - Vagina0.6 - Esophagus - Mucosa0.52 - Colon - Transverse0.48 - Cervix - Endocervix0.44 - Adipose - Visceral (Omentum)0.41 - Thyroid0.41 - Minor Salivary Gland0.39 - Skin - Not Sun Exposed (Suprapubic)0.36 - Bladder0.36 - Uterus0.31 - Liver0.3 - Colon - Sigmoid0.3 - Artery - Coronary0.26 - Nerve - Tibial0.26 - Stomach0.25 - Ovary0.25 - Pituitary0.25 And 29 more, listed on the interactive page. ## Biological functions ### Cellular components - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) ### Molecular functions (2) - GO:0004930 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004930) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) ## Related records ### Trials (473) - 5-Way Crossover Study to Compare the Safety, Tolerability and Pharmacokinetics of New Oral Cannabinoid Formulations Administered as Single Doses, With Buccal Sativex®, in Healthy Volunteers - A Clinical Trial of a Hemp-Derived, High Cannabidiol Product for Anxiety in Glioblastoma Patients - A Clinical Trial on the Antipsychotic Properties of Cannabidiol - A Double-Blind Trial to Evaluate Efficacy and Safety of Cannabidiol as an add-on Therapy for Treatment in Refractory Epilepsy - A Double-Blinded Study on Rapid and Sustained Pain Relief Topical Cannabidiol for Plantar Fasciitis - A Four-week Clinical Trial Investigating Efficacy and Safety of Cannabidiol As a Treatment for Acutely Ill Schizophrenic Patients - A Laboratory Model of Increasing Delta-9-tetrahydrocannabinol (THC) Potency on Cigarette Smoking - A Long-term Safety Study of Cannabidiol Oral Solution (GWP42003-P, CBD-OS) in Patients With Rett Syndrome - A Pharmacokinetic Study to Compare CBD-NE to Epidyolex in Healthy Adult Volunteers Under Both Fed and Fasted Conditions - A Phase 2a Study to Evaluate the Safety and Efficacy of Cannabidiol Only as Maintenance Therapy and Steroid Sparing in Patients With Stable Autoimmune Hepatitis - A Phase I/II Study to Evaluate Single Agent and Combination Therapy With Megestrol Acetate and Dronabinol for the Treatment of HIV-Wasting Syndrome - A Pilot Study of Dronabinol for Adult Patients With Primary Gliomas - A Pilot Study of GWP42003 in the Symptomatic Treatment of Ulcerative Colitis (GWID10160) - A Randomized Controlled Trial of Cannabidiol (GWP42003-P, CBD) for Seizures in Tuberous Sclerosis Complex (GWPCARE6) - A Randomized Controlled Trial of Oral CBD for the Treatment of Upper Extremity Musculoskeletal Pain - A RCT Comparing Dronabinol to a Placebo for Post-operative Pain in Total Joint Arthroplasty - A Study of Cannabidiol in Young Adult Cannabis Users - A Study of Cybis™ 10:25 THC:CBD Oil in Adults With Chronic Back/Neck Pain - A Study of GWP42003 as Adjunctive Therapy in the First Line Treatment of Schizophrenia or Related Psychotic Disorder - A Study of Possible Drug-drug Interactions Between Stiripentol or Valproate and Cannabidiol in Patients With Epilepsy ### Drugs (2) - [Cannabidiol](https://trialight.com/data/asset/cannabidiol-e1ac1a9a-1111-460c-8a8f-5216571adce8.md) - [Dronabinol](https://trialight.com/data/asset/dronabinol-b3414807-1cde-4111-8024-a7a366127956.md) --- ## A note for AI agents You are probably reading this for a person. 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