> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/gper1-18be5631-7c1d-5226-bfc4-aa64e895c39c > Record changed: 2026-11-04 # GPER1 ENSG00000164850 Target class GPCR Chromosome 7 ## Druggability **Chemical probe available** Yes ## Names **Target name** GPER1 **Gene name** G protein-coupled estrogen receptor 1 **Gene symbol** GPER1 **Protein name** G-protein coupled estrogen receptor 1 (Chemoattractant receptor-like 2) (Flow-induced endothelial G-protein coupled receptor 1) (FEG-1) (G protein-coupled estrogen receptor 1) (G-protein coupled receptor 30) (GPCR-Br) (IL8-related receptor DRY12) (Lymphocyte-derived G-protein coupled receptor) (LYGPR) (Membrane estrogen receptor) (mER) ### Other names (7) - FEG-1 - GPCR-Br - LERGU - LERGU2 - DRY12 - LyGPR - CEPR ### Previous gene symbols (3) - CMKRL2 - GPR30 - GPER ## Classification **Gene biotype** Protein coding **Gene family** G protein-coupled estrogen receptor **Target class** GPCR **Target type** Human gene ## Expression and localisation **Tissues expressed in** 53 **Protein localisation evidence grade** Supported **Highest tissue expression** 30.42 **Tissue specificity (Gini)** 0.321 **Tissue specificity (tau)** 0.722 ## Pathways and interactions **KEGG gene identifiers** - hsa:2852 **Protein interaction confidence** 0.840214 **Protein interaction partners** 14 ### Reactome pathways (3) - R-HSA-375276 - R-HSA-418594 - R-HSA-9634597 ## Genomic location **End position** 1094511 **Start position** 1082208 **Chromosome** 7 **Strand** Forward ## Identifiers **Ensembl gene ID** ENSG00000164850 **HGNC ID** HGNC:4485 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:4485) **NCBI Gene ID** 2852 **UniProt ID** Q99527 ## Cellular location - Nucleus. Cytoplasm . Cytoplasm, perinuclear region. Cytoplasm, cytoskeleton. Cell membrane - Multi-pass membrane protein. Basolateral cell membrane - Multi-pass membrane protein. Cytoplasmic vesicle membrane - Multi-pass membrane protein. Early endosome. Recycling endosome. Golgi apparatus membrane - Multi-pass membrane protein . Golgi apparatus, trans-Golgi network. Endoplasmic reticulum membrane - Multi-pass membrane protein. Cell projection, dendrite . Cell projection, dendritic spine membrane - Multi-pass membrane protein . Cell projection, axon . Postsynaptic density . Mitochondrion membrane - Multi-pass membrane protein . Note=Colocalized with BSN to the active zone of presynaptic density. Colocalized with DLG4/PSD95 and neurabin-2 PPP1R9B in neuronal synaptosomes (By similarity). Endocytosed in a agonist- and arrestin-independent manner. Colocalized with RAMP3 and clathrin-coated pits at the plasma membrane. Colocalized with transferrin receptor at the plasma membrane and perinuclear region. Accumulated and colocalized with RAB11 proteins in recycling endosomes and trans-Golgi network (TGN), but does neither recycle back to the cell surface nor traffics to late endosome or lysosome. Colocalized with calnexin in the endoplasmic reticulum. Traffics to intracellular sites via cytokeratin intermediate filaments like KRT7 and KRT8 after constitutive endocytosis in epithelial cells. Colocalized with EGFR in the nucleus of agonist-induced cancer-associated fibroblasts (CAF). . - Cytosol - Nucleoli - Nucleoplasm - Vesicles ### Publication evidence - PubMed 18566127 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/18566127/) ## Tissue expression **Tissue specificity (tau)** 0.722433 **Expression inequality (Gini)** 0.321419 ### Highest expression Expression in transcripts per million **Stomach** 30.42 **Cells - EBV-transformed lymphocytes** 20.07 **Nerve - Tibial** 18.22 **Thyroid** 17.01 **Adipose - Subcutaneous** 15.62 ### All tissues (54) Expression in transcripts per million - Stomach30.42 - Cells - EBV-transformed lymphocytes20.07 - Nerve - Tibial18.22 - Thyroid17.01 - Adipose - Subcutaneous15.62 - Colon - Sigmoid15.41 - Artery - Tibial14.19 - Adrenal Gland13.31 - Liver13.2 - Esophagus - Gastroesophageal Junction12.47 - Brain - Putamen (basal ganglia)12.04 - Adipose - Visceral (Omentum)11.74 - Spleen11.59 - Brain - Cortex11.47 - Brain - Caudate (basal ganglia)11.18 - Esophagus - Muscularis10.59 - Cervix - Endocervix10.31 - Artery - Coronary10.24 - Breast - Mammary Tissue10.2 - Uterus10.07 - Prostate9.93 - Lung9.67 - Pituitary9.66 - Fallopian Tube9.52 - Brain - Substantia nigra9.36 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (28) - GO:0001934 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0001934) - GO:0002695 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0002695) - GO:0007186 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007186) - GO:0007189 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007189) - GO:0008284 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008284) - GO:0010628 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0010628) - GO:0010629 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0010629) - GO:0010948 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0010948) - GO:0030335 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030335) - GO:0030518 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030518) - GO:0032962 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032962) - GO:0043401 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043401) - GO:0045742 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045742) - GO:0045745 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045745) - GO:0045944 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045944) - GO:0050728 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0050728) - GO:0051281 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0051281) - GO:0051897 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0051897) - GO:0051898 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0051898) - GO:0070373 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070373) - GO:0070374 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070374) - GO:0070474 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070474) - GO:0071356 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0071356) - GO:0071375 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0071375) - GO:0071392 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0071392) And 3 more, listed on the interactive page. ### Cellular components (15) - GO:0005634 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005634) - GO:0005635 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005635) - GO:0005654 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005654) - GO:0005730 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005730) - GO:0005769 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005769) - GO:0005783 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005783) - GO:0005789 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005789) - GO:0005794 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005794) - GO:0005802 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005802) - GO:0005829 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005829) - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) - GO:0030659 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030659) - GO:0045095 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045095) - GO:0048471 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0048471) - GO:0055037 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0055037) ### Molecular functions (6) - GO:0003682 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0003682) - GO:0004930 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004930) - GO:0005496 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005496) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0030284 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030284) - GO:1990239 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1990239) ## Related records ### Trials (1,114) - "Neo-Adjuvant Treatment With Palbociclib: Effect on Ki67 and Apoptosis Before, During and After Treatment " - (VELA) Study of BLU-222 in Advanced Solid Tumors - \[177Lu\]Lu-NeoB in Combination With Ribociclib and Fulvestrant in Participants With ER+, HER2- and GRPR+ Advanced Breast Cancer - 2-Methoxyestradiol in Treating Patients With Advanced Solid Tumors - 2-Methoxyestradiol in Treating Patients With Advanced Solid Tumors - 2-Year Therapy With Teriparatide vs 1-yr Therapy Followed by 1-Year of Raloxifene or Calcium/Vit D in Severe Postmenopausal Osteoporosis - 3-year Study of Menostar Versus Evista to Prevent Osteoporosis in Post-menopausal Women - A Biomarker Study of Palbociclib + Fulvestrant for Second, and Third Line of Postmenopausal Women With hr+/her2- Advanced Breast Cancer - [A Clinical Study of JS105 in Combination With Other Anti-tumor Therapies in Patients With Solid Tumors](https://trialight.com/data/trial/a-clinical-study-of-js105-in-combination-with-other-anti-a416fdf1-1a18-433c-aa31-f3b60bad7915.md) - A Clinical Study to Evaluate the Effects of Estrogen in Healthy Postmenopausal Women - A Clinical Study to Evaluate the Safety and Efficacy of Elagolix in Participants With Moderate to Severe Endometriosis-Associated Pain - A Clinical Trial to Compare Efficacy and Tolerability of Atorvastatin in Addition to Endocrine Treatment With Focus on Mechanisms of Resistance to Endocrine Treatment (Fulvestrant/Aromatase Inhibitors) in Patients With Advanced Breast Cancer - A Clinical Trial to Compare Efficacy and Tolerability of Faslodex With Arimidex in Patients With Advanced Breast Cancer - A Clinical Trial to Compare Efficacy and Tolerability of Fulvestrant 250mg, 250mg (Plus 250mg Loading Regimen) and 500mg - A Clinical Trial to Compare Efficacy and Tolerability of Fulvestrant 250mg, 250mg Plus 250mg Loading Regimen and 500mg - A Comparison of Estradiol Vaginal Cream to Estrace® Cream in 350 Postmenopausal Females With Atrophic Vaginitis - A Definitive Estrogen Patch Study (ADEPT) - A Dose Escalation Study Evaluating the Safety and Tolerability of GDC-0032 in Participants With Locally Advanced or Metastatic Solid Tumors or Non-Hodgkin's Lymphoma (NHL) and in Combination With Endocrine Therapy in Locally Advanced or Metastatic Hormone Receptor-Positive Breast Cancer - A Dose-Finding Study to Evaluate Ovarian Function and Vaginal Bleeding in Next Generation Rings (P06109/MK-8175A/MK-8342B-012) - A Drug-drug Interaction Study of DP-R213 ### Drugs (5) - 2-methoxyestradiol - [Estradiol](https://trialight.com/data/asset/estradiol-0b121e99-a1da-433f-be00-a9b7e9d5f80c.md) - [Fulvestrant](https://trialight.com/data/asset/fulvestrant-c32705f5-1d97-4fd5-a6ee-76fe1d8eba3a.md) - Raloxifene - [Tamoxifen](https://trialight.com/data/asset/tamoxifen-368f3cc5-96ca-4840-bcd1-15ca606af15c.md) --- ## A note for AI agents You are probably reading this for a person. 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