> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/gnrhr-ac2ad3c8-85c9-5310-a5fb-e2b215542909 > Record changed: 2026-10-13 # GNRHR ENSG00000109163 Target class GPCR Chromosome 4 Approved drugs 18 Clinical candidates (approved and in development) 25 ## Clinical evidence **Approved drugs** 18 **Clinical candidates (approved and in development)** 25 ## Druggability **Chemical probe available** Yes ## Names **Other names** - LHRHR **Target name** GNRHR **Gene name** Gonadotropin releasing hormone receptor **Gene symbol** GNRHR **Previous gene symbols** - GRHR **Protein name** Gonadotropin-releasing hormone receptor (GnRH receptor) (GnRH-R) ## Classification **Gene biotype** Protein coding **Gene family** Gonadotropin releasing hormone receptors **Target class** GPCR **Target type** Human gene ## Expression and localisation **Tissues expressed in** 1 **Highest tissue expression** 6.38 **Tissue specificity (Gini)** 0.591 **Tissue specificity (tau)** 0.973 ## Pathways and interactions **KEGG gene identifiers** - hsa:2798 **Protein interaction confidence** 0.8665 **Protein interaction partners** 16 ### Reactome pathways (2) - R-HSA-375281 - R-HSA-416476 ## Genomic location **End position** 67754388 **Start position** 67737118 **Chromosome** 4 **Strand** Reverse ## Identifiers **Ensembl gene ID** ENSG00000109163 **HGNC ID** HGNC:4421 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:4421) **NCBI Gene ID** 2798 **UniProt ID** P30968 ## Cellular location - Cell membrane - Multi-pass membrane protein. ## Tissue expression **Tissue specificity (tau)** 0.973325 **Expression inequality (Gini)** 0.590981 ### Highest expression Expression in transcripts per million **Pituitary** 6.38 **Vagina** 0.5 **Brain - Cerebellum** 0.42 **Cells - EBV-transformed lymphocytes** 0.42 **Brain - Cerebellar Hemisphere** 0.41 ### All tissues (54) Expression in transcripts per million - Pituitary6.38 - Vagina0.5 - Brain - Cerebellum0.42 - Cells - EBV-transformed lymphocytes0.42 - Brain - Cerebellar Hemisphere0.41 - Thyroid0.37 - Nerve - Tibial0.33 - Esophagus - Mucosa0.32 - Cervix - Endocervix0.28 - Cervix - Ectocervix0.26 - Minor Salivary Gland0.25 - Brain - Frontal Cortex (BA9)0.24 - Ovary0.23 - Prostate0.23 - Kidney - Medulla0.21 - Brain - Cortex0.21 - Cells - Cultured fibroblasts0.21 - Uterus0.19 - Bladder0.19 - Brain - Hypothalamus0.17 - Testis0.16 - Brain - Anterior cingulate cortex (BA24)0.16 - Artery - Coronary0.16 - Brain - Nucleus accumbens (basal ganglia)0.16 - Artery - Aorta0.15 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes - GO:0007186 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007186) ### Cellular components (2) - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) - GO:0016020 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016020) ### Molecular functions - GO:0004968 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004968) ## Related records ### Trials (1,215) - (Z)-Endoxifen for the Treatment of Premenopausal Women With ER+/HER2- Breast Cancer - 12-week Open-label Evaluation of Efficacy and Safety of Indacaterol - 3-arm Study of Abiraterone Acetate Alone, Abiraterone Acetate Plus Degarelix, a GnRH Antagonist, and Degarelix Alone for Patients With Prostate Cancer With a Rising PSA or a Rising PSA and Nodal Disease Following Definitive Radical Prostatectomy - 90% Effective Dose of Norepinephrine Infusions Under Intensive and Standard Treatment - 90% Effective Dose of Norepinephrine Infusions Under Intensive and Standard Treatment in Preeclamptic Patients - 90% Effective Dose of Phenylephrine Infusions Under Intensive and Standard Treatment - 90% Effective Dose of Phenylephrine Infusions Under Intensive and Standard Treatment in Preeclamptic Patients - A Clinical Study Evaluating The Benefit of Adding Rucaparib to Enzalutamide for Men With Metastatic Prostate Cancer That Has Become Resistant To Testosterone-Deprivation Therapy - A Clinical Study of KLH-2109 in Patients With Endometriosis - A Clinical Study of KLH-2109 in Uterine Fibroids Patient With Menorrhagia - A Clinical Study of KLH-2109 in Uterine Fibroids Patient With Menorrhagia and Pain - A Clinical Study of SHR-1314 Injection in the Treatment of Moderate to Severe Plaque Psoriasis in Adults - A Clinical Study to Evaluate the Safety and Efficacy of Elagolix in Participants With Moderate to Severe Endometriosis-Associated Pain - A Clinical Study to Evaluate the Safety and Efficacy of Elagolix in Subjects With Moderate to Severe Endometriosis-Associated Pain - A Clinical Trial to Evaluate Efficacy and Safety of Elagolix Tablets in Women With Moderate or Severe Endometriosis-associated Pain - A Comparative Study of AZD9833 Plus Palbociclib Versus Anastrozole Plus Palbociclib in Patients With ER-Positive HER2 Negative Breast Cancer Who Have Not Received Any Systemic Treatment for Advanced Disease - A Comparative Study of Degarelix Three-month Depot in Three Different Dosing Regimens in Patients With Prostate Cancer - A Comparison of Symbicort® Single Inhaler Therapy and Conventional Best Practice for the Treatment of Persistent Asthma - A Degarelix Trial in Patients With Prostate Cancer - A Food Effect Study of TAK-385 Final Formulation ### Drugs (33) - Abarelix Gonadotropin-releasing hormone receptor antagonist - Acyline Gonadotropin-releasing hormone receptor antagonist - Buserelin Gonadotropin-releasing hormone receptor agonist - Cetrorelix Gonadotropin-releasing hormone receptor antagonist - Cetrorelix acetate Gonadotropin-releasing hormone receptor antagonist - Degarelix Gonadotropin-releasing hormone receptor antagonist - Degarelix acetate Gonadotropin-releasing hormone receptor antagonist - Elagolix Gonadotropin-releasing hormone receptor antagonist - Elagolix sodium Gonadotropin-releasing hormone receptor antagonist - Ganirelix Gonadotropin-releasing hormone receptor antagonist - Ganirelix acetate Gonadotropin-releasing hormone receptor antagonist - [Gonadorelin](https://trialight.com/data/asset/gonadorelin-8424d688-4462-4eb8-8a4b-86a101540a4a.md) Gonadotropin-releasing hormone receptor agonist - Gonadorelin acetate Gonadotropin-releasing hormone receptor agonist - Gonadorelin hydrochloride Gonadotropin-releasing hormone receptor agonist - Goserelin Gonadotropin-releasing hormone receptor agonist - [Goserelin acetate](https://trialight.com/data/asset/goserelin-acetate-90bac5a2-7664-42a1-bb3d-213f4770a9b7.md) Gonadotropin-releasing hormone receptor agonist - Histrelin Gonadotropin-releasing hormone receptor agonist - Histrelin acetate Gonadotropin-releasing hormone receptor agonist - Leuprolide Gonadotropin-releasing hormone receptor agonist - [Leuprolide acetate](https://trialight.com/data/asset/leuprolide-acetate-69c5b838-1510-4a84-a80f-f227002be449.md) Gonadotropin-releasing hormone receptor agonist --- ## A note for AI agents You are probably reading this for a person. 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