> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/glra3-50f13d74-b662-5f15-a6a8-22aa17dc3372 > Record changed: 2026-11-04 # GLRA3 ENSG00000145451 Target class Ion channel Chromosome 4 ## Druggability **Chemical probe available** No ## Names **Target name** GLRA3 **Gene name** Glycine receptor alpha 3 **Gene symbol** GLRA3 **Protein name** Glycine receptor subunit alpha-3 ## Classification **Gene biotype** Protein coding **Gene family** Glycine receptors **Target class** Ion channel **Target type** Human gene ## Expression and localisation **Tissues expressed in** 4 **Protein localisation evidence grade** Approved **Highest tissue expression** 3.39 **Tissue specificity (Gini)** 0.839 **Tissue specificity (tau)** 0.928 ## Pathways and interactions **KEGG gene identifiers** - hsa:8001 **Reactome pathways** - R-HSA-112314 **Protein interaction confidence** 0.837 **Protein interaction partners** 2 ## Genomic location **End position** 174829247 **Start position** 174636920 **Chromosome** 4 **Strand** Reverse ## Identifiers **Ensembl gene ID** ENSG00000145451 **HGNC ID** HGNC:4328 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:4328) **NCBI Gene ID** 8001 **UniProt ID** O75311 ## Cellular location - Postsynaptic cell membrane - Multi-pass membrane protein . Perikaryon . Cell projection, dendrite . Synapse . Cell membrane - Multi-pass membrane protein . Note=Partially colocalizes with GPHN that is known to mediate receptor clustering at postsynaptic membranes. . - Plasma membrane ### Publication evidence (2) - PubMed 26416729 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/26416729/) - PubMed 9677400 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/9677400/) ## Tissue expression **Tissue specificity (tau)** 0.927868 **Expression inequality (Gini)** 0.838543 ### Highest expression Expression in transcripts per million **Brain - Frontal Cortex (BA9)** 3.39 **Brain - Hypothalamus** 2.77 **Brain - Cortex** 2.28 **Brain - Anterior cingulate cortex (BA24)** 1.98 **Brain - Substantia nigra** 0.96 ### All tissues (54) Expression in transcripts per million - Brain - Frontal Cortex (BA9)3.39 - Brain - Hypothalamus2.77 - Brain - Cortex2.28 - Brain - Anterior cingulate cortex (BA24)1.98 - Brain - Substantia nigra0.96 - Brain - Amygdala0.94 - Pituitary0.88 - Brain - Nucleus accumbens (basal ganglia)0.77 - Testis0.6 - Brain - Caudate (basal ganglia)0.41 - Brain - Hippocampus0.29 - Brain - Putamen (basal ganglia)0.16 - Brain - Cerebellum0.15 - Brain - Spinal cord (cervical c-1)0.12 - Breast - Mammary Tissue0.08 - Small Intestine - Terminal Ileum0.06 - Brain - Cerebellar Hemisphere0.05 - Cervix - Endocervix0.04 - Uterus0.04 - Skin - Sun Exposed (Lower leg)0.04 - Esophagus - Muscularis0.03 - Pancreas0.03 - Esophagus - Gastroesophageal Junction0.03 - Spleen0.03 - Lung0.03 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (2) - GO:0051260 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0051260) - GO:1902476 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1902476) ### Cellular components (2) - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) - GO:0016935 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016935) ### Molecular functions (3) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0016934 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016934) - GO:0022852 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0022852) ## Related records ### Trials (347) - A Laboratory Model of Increasing Delta-9-tetrahydrocannabinol (THC) Potency on Cigarette Smoking - A Phase I/II Study to Evaluate Single Agent and Combination Therapy With Megestrol Acetate and Dronabinol for the Treatment of HIV-Wasting Syndrome - A Pilot Study of Dronabinol for Adult Patients With Primary Gliomas - A RCT Comparing Dronabinol to a Placebo for Post-operative Pain in Total Joint Arthroplasty - A Relative Bioavailability Study of 60 mg Nifedipine ER Tablets Under Non-fasting Conditions - A Relative Bioavailability Study of 60 mg Nifedipine Extended Release Tablets Under Fasting Conditions - A Study Examining the Use of Vaginal Nifedipine With Pelvic Floor Physical Therapy for Levator Myalgia and Pelvic Pain - A Study of Cybis™ 10:25 THC:CBD Oil in Adults With Chronic Back/Neck Pain - A Study of Nifecardia SRFC and Adalat OROS in the Treatment of Patients With Essential Hypertension - A Study Of Synthetic THC And Sleep - A Study of the Abuse Potential of Dronabinol in Recreational Cannabinoid Users - A Study Testing the Safety and Effects of Single Doses of S1-221 in Healthy Volunteers - Abuse Potential of Sativex - Activation of the Endocannabinoid System and Cognition - Acute Effects of Cannabis on Cognition and Affect - Acute Effects of THC in Older Adult - Adalat XL vs Diltiazem on Proteinuria and Blood Pressure in Hypertensive Diabetic Patients - Add on Study on Δ9-THC Treatment for Posttraumatic Stress Disorders (PTSD) - Age-dependent Effects of Smoked and Oral Delta-9-THC - Age-Related Effects of THC ### Drugs (4) - [Dronabinol](https://trialight.com/data/asset/dronabinol-b3414807-1cde-4111-8024-a7a366127956.md) - Nifedipine - Onternabez - Strychnine --- ## A note for AI agents You are probably reading this for a person. 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