> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/glra2-6c55df14-559f-549d-a1b5-2edf73cb66a9 > Record changed: 2026-11-04 # GLRA2 ENSG00000101958 Target class Ion channel Chromosome X ## Druggability **Chemical probe available** No ## Names **Target name** GLRA2 **Gene name** Glycine receptor alpha 2 **Gene symbol** GLRA2 **Previous gene symbols** - GLR **Protein name** Glycine receptor subunit alpha-2 ## Classification **Gene biotype** Protein coding **Gene family** Glycine receptors **Target class** Ion channel **Target type** Human gene ## Expression and localisation **Tissues expressed in** 8 **Protein localisation evidence grade** Approved **Highest tissue expression** 16.43 **Tissue specificity (Gini)** 0.886 **Tissue specificity (tau)** 0.955 ## Pathways and interactions **KEGG gene identifiers** - hsa:2742 **Reactome pathways** - R-HSA-112314 **Protein interaction confidence** 0.781 **Protein interaction partners** 2 ## Genomic location **End position** 14731812 **Start position** 14529298 **Chromosome** X **Strand** Forward ## Identifiers **Ensembl gene ID** ENSG00000101958 **HGNC ID** HGNC:4327 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:4327) **NCBI Gene ID** 2742 **UniProt ID** P23416 ## Cellular location - Postsynaptic cell membrane - Multi-pass membrane protein . Synapse . Cell membrane - Multi-pass membrane protein . Cell projection . - Plasma membrane ### Publication evidence (6) - PubMed 15302677 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/15302677/) - PubMed 16144831 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/16144831/) - PubMed 2155780 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/2155780/) - PubMed 23895467 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/23895467/) - PubMed 25445488 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/25445488/) - PubMed 26370147 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/26370147/) ## Tissue expression **Tissue specificity (tau)** 0.955006 **Expression inequality (Gini)** 0.885629 ### Highest expression Expression in transcripts per million **Brain - Cerebellar Hemisphere** 16.43 **Brain - Cerebellum** 13.41 **Brain - Hypothalamus** 8.12 **Brain - Nucleus accumbens (basal ganglia)** 3.42 **Brain - Anterior cingulate cortex (BA24)** 2.98 ### All tissues (54) Expression in transcripts per million - Brain - Cerebellar Hemisphere16.43 - Brain - Cerebellum13.41 - Brain - Hypothalamus8.12 - Brain - Nucleus accumbens (basal ganglia)3.42 - Brain - Anterior cingulate cortex (BA24)2.98 - Brain - Amygdala2.71 - Brain - Frontal Cortex (BA9)2.42 - Brain - Cortex1.7 - Brain - Caudate (basal ganglia)0.81 - Brain - Putamen (basal ganglia)0.72 - Brain - Spinal cord (cervical c-1)0.51 - Brain - Substantia nigra0.5 - Brain - Hippocampus0.5 - Pituitary0.43 - Colon - Transverse0.23 - Colon - Sigmoid0.14 - Nerve - Tibial0.11 - Ovary0.09 - Small Intestine - Terminal Ileum0.07 - Testis0.07 - Fallopian Tube0.04 - Cervix - Endocervix0.04 - Kidney - Cortex0.03 - Cells - Cultured fibroblasts0.02 - Esophagus - Muscularis0.02 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (6) - GO:0007218 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007218) - GO:0034220 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0034220) - GO:0071230 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0071230) - GO:0071294 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0071294) - GO:0071361 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0071361) - GO:1902476 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1902476) ### Cellular components - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) ### Molecular functions (3) - GO:0016594 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016594) - GO:0016934 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016934) - GO:0022852 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0022852) ## Related records ### Trials (501) - A Drug-Food Interaction Study Between Colchicine and Grapefruit Juice - A Laboratory Model of Increasing Delta-9-tetrahydrocannabinol (THC) Potency on Cigarette Smoking - A Ph2, Colchicine For Inflammatory Carotid Injury And Disease Evolution After Radiotherapy - A Pharmacokinetic Study of Colchicine With an Oral Contraceptive - A Phase 4 Safety and Efficacy Study to Evaluate Lesinurad 200 mg in Participants With Gout and Renal Impairment - A Phase I/II Study to Evaluate Single Agent and Combination Therapy With Megestrol Acetate and Dronabinol for the Treatment of HIV-Wasting Syndrome - A Pilot Study for PK/PD Parameter of Colchicine in Chronic Kidney Disease Patient. - A Pilot Study of Dronabinol for Adult Patients With Primary Gliomas - A Pilot Trial Evaluating the Effect of Tropisetron on Postoperative Cognitive Dysfunction After Cardiac Surgery - A Randomized Multicenter Study for Isolated Skin Vasculitis - A RCT Comparing Dronabinol to a Placebo for Post-operative Pain in Total Joint Arthroplasty - A Study Evaluating the Efficacy and Safety of Aprepitant in Autologous Hematopoietic Stem Cell Transplantation - A Study of Cybis™ 10:25 THC:CBD Oil in Adults With Chronic Back/Neck Pain - A Study of SSGJ-613 in Gout Participants Initiating Urate-Lowering Treatment - A Study of SSGJ-613 in Gout Subjects Initiating Urate-Lowering Treatment. - A Study Of Synthetic THC And Sleep - A Study of the Abuse Potential of Dronabinol in Recreational Cannabinoid Users - A Study of the Efficacy of Canakinumab in Prevention of Acute Flares in Chronic Gout Patients Initiating Allopurinol Therapy (Core Study) and a Long-term Study of the Efficacy and Safety of Canakinumab in Patients With Gout (Extension Study) - A Study of the Efficacy of Genakumab in Prevention of Acute Flares in Gout Patients Initiating Urate-lowering TherapyUrate-lowering (GenSci048-202) - A Study Testing the Safety and Effects of Single Doses of S1-221 in Healthy Volunteers ### Drugs (5) - [Colchicine](https://trialight.com/data/asset/colchicine-ae804b3e-3263-453f-abb3-ae1e813f2ccf.md) - [Dronabinol](https://trialight.com/data/asset/dronabinol-b3414807-1cde-4111-8024-a7a366127956.md) - Onternabez - Strychnine - Tropisetron --- ## A note for AI agents You are probably reading this for a person. 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