> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/glra1-29fb462a-e9de-5f51-8154-00cd3c1aa451 > Record changed: 2026-11-04 # GLRA1 ENSG00000145888 Target class Ion channel Chromosome 5 Approved drugs 6 Clinical candidates (approved and in development) 6 ## Clinical evidence **Approved drugs** 6 **Clinical candidates (approved and in development)** 6 ## Druggability **Chemical probe available** No ## Names **Target name** GLRA1 **Gene name** Glycine receptor alpha 1 **Gene symbol** GLRA1 **Previous gene symbols** - STHE **Protein name** Glycine receptor subunit alpha-1 (Glycine receptor 48 kDa subunit) (Glycine receptor strychnine-binding subunit) ## Classification **Gene biotype** Protein coding **Gene family** Glycine receptors **Target class** Ion channel **Target type** Human gene ## Expression and localisation **Tissues expressed in** 0 **Protein localisation evidence grade** Approved **Highest tissue expression** 0.81 **Tissue specificity (Gini)** 0.764 **Tissue specificity (tau)** 0.94 ## Pathways and interactions **KEGG gene identifiers** - hsa:2741 **Reactome pathways** - R-HSA-112314 **Protein interaction confidence** 0.8335 **Protein interaction partners** 6 ## Genomic location **End position** 151924851 **Start position** 151822513 **Chromosome** 5 **Strand** Reverse ## Identifiers **Ensembl gene ID** ENSG00000145888 **HGNC ID** HGNC:4326 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:4326) **NCBI Gene ID** 2741 **UniProt ID** P23415 ## Cellular location - Postsynaptic cell membrane - Multi-pass membrane protein . Synapse . Perikaryon . Cell projection, dendrite . Cell membrane - Multi-pass membrane protein . - Plasma membrane ### Publication evidence (13) - PubMed 14551753 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/14551753/) - PubMed 16144831 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/16144831/) - PubMed 2155780 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/2155780/) - PubMed 22715885 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/22715885/) - PubMed 22973015 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/22973015/) - PubMed 24108130 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/24108130/) - PubMed 25445488 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/25445488/) - PubMed 25730860 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/25730860/) - PubMed 25973519 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/25973519/) - PubMed 7920629 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/7920629/) - PubMed 7925268 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/7925268/) - PubMed 9009272 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/9009272/) - PubMed 23994010 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/23994010/) ## Tissue expression **Tissue specificity (tau)** 0.940368 **Expression inequality (Gini)** 0.764315 ### Highest expression Expression in transcripts per million **Brain - Hypothalamus** 0.81 **Brain - Substantia nigra** 0.57 **Brain - Cerebellum** 0.31 **Brain - Cerebellar Hemisphere** 0.31 **Brain - Spinal cord (cervical c-1)** 0.25 ### All tissues (54) Expression in transcripts per million - Brain - Hypothalamus0.81 - Brain - Substantia nigra0.57 - Brain - Cerebellum0.31 - Brain - Cerebellar Hemisphere0.31 - Brain - Spinal cord (cervical c-1)0.25 - Brain - Putamen (basal ganglia)0.13 - Pancreas0.08 - Testis0.08 - Brain - Caudate (basal ganglia)0.07 - Brain - Frontal Cortex (BA9)0.06 - Brain - Cortex0.06 - Fallopian Tube0.05 - Brain - Amygdala0.05 - Brain - Nucleus accumbens (basal ganglia)0.04 - Brain - Anterior cingulate cortex (BA24)0.04 - Nerve - Tibial0.03 - Cells - Cultured fibroblasts0.03 - Thyroid0.03 - Cells - EBV-transformed lymphocytes0.03 - Adrenal Gland0.03 - Brain - Hippocampus0.02 - Lung0.02 - Muscle - Skeletal0.02 - Adipose - Visceral (Omentum)0.02 - Artery - Coronary0.02 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (12) - GO:0001964 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0001964) - GO:0006811 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006811) - GO:0006821 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006821) - GO:0006936 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006936) - GO:0007218 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007218) - GO:0042391 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042391) - GO:0051970 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0051970) - GO:0071230 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0071230) - GO:0071294 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0071294) - GO:0071361 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0071361) - GO:1902476 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1902476) - GO:2000344 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:2000344) ### Cellular components (2) - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) - GO:0043231 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043231) ### Molecular functions (6) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0008270 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008270) - GO:0016594 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016594) - GO:0016934 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016934) - GO:0030977 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030977) - GO:0099507 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0099507) ## Related records ### Trials (1,359) - 1-1-8 Wash-in for Sevoflurane Low Flow Anesthesia - 3 mL Inhaled Methoxyflurane for Intrauterine Device (IUD) Insertion - 50% Effective Concentration of Sevoflurane for Immobility - A Comparison Between Oral Melatonin With Nasal Sevoflurane Versus Oral Chloral Hydrate With Nasal Sevoflurane in Sedation of Children Undergoing Brain MRI - A Comparison of Desflurane vs. Sevoflurane and the Time to Awakening and the Incidence and Severity of Cough - A Comparison of Emergence Agitation by Sevoflurane for Intraoperative Sedation Associated With Caudal Block - A Comparison of Kidney Function After Nephrectomy in Living Donors Under Sevoflurane and Desflurane Anesthesia - A Comparison of Propofol Based Total Intravenous Anesthesia and Desflurane Based Balanced Anesthesia on Hepatic Protection During Living-donor Liver Transplantation - A Comparison of Propofol Based Total Intravenous Anesthesia and Desflurane Based Balanced Anesthesia on Renal Protection During Deceased Brain Dead Donor Kidney Transplantation - A Prospective, Randomized Trial - A Comparison of Propofol Based Total Intravenous Anesthesia and Sevoflurane Based Balanced Anesthesia on Renal Protection During Lung Transplantation Under Extracorporeal Membrane Oxygenation - A Prospective, Randomized Trial - A Comparison of Three Regimens of Acute Pain Management: Methoxyflurane; Intranasal Fentanyl; Intravenous Morphine - A Comparison of Two Anaesthetic Methods of Protecting Heart Tissue During Cardiac Surgery - A Drug-Food Interaction Study Between Colchicine and Grapefruit Juice - A Laboratory Model of Increasing Delta-9-tetrahydrocannabinol (THC) Potency on Cigarette Smoking - A Ph2, Colchicine For Inflammatory Carotid Injury And Disease Evolution After Radiotherapy - A Pharmacokinetic Study of Colchicine With an Oral Contraceptive - A Phase 4 Safety and Efficacy Study to Evaluate Lesinurad 200 mg in Participants With Gout and Renal Impairment - A Phase I/II Study to Evaluate Single Agent and Combination Therapy With Megestrol Acetate and Dronabinol for the Treatment of HIV-Wasting Syndrome - A Pilot Study for PK/PD Parameter of Colchicine in Chronic Kidney Disease Patient. - A Pilot Study of Dronabinol for Adult Patients With Primary Gliomas ### Drugs (12) - [Colchicine](https://trialight.com/data/asset/colchicine-ae804b3e-3263-453f-abb3-ae1e813f2ccf.md) - Desflurane Glycine receptor (alpha-1/beta) positive modulator - [Dronabinol](https://trialight.com/data/asset/dronabinol-b3414807-1cde-4111-8024-a7a366127956.md) - Enflurane Glycine receptor (alpha-1/beta) positive modulator - Halothane Glycine receptor (alpha-1/beta) positive modulator - Isoflurane Glycine receptor (alpha-1/beta) positive modulator - Methoxyflurane Glycine receptor (alpha-1/beta) agonist - Nifedipine - Onternabez - Sevoflurane Glycine receptor (alpha-1/beta) positive modulator - Strychnine - Tropisetron --- ## A note for AI agents You are probably reading this for a person. 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