GLRA1
ENSG00000145888
Target class
Ion channel
Chromosome
5
Approved drugs
6
Clinical candidates (approved and in development)
6
- Approved drugs
- 6
- Clinical candidates (approved and in development)
- 6
- Chemical probe available
- No
- Target name
- GLRA1
- Gene name
- Glycine receptor alpha 1
- Gene symbol
- GLRA1
- Previous gene symbols
- STHE
- Protein name
- Glycine receptor subunit alpha-1 (Glycine receptor 48 kDa subunit) (Glycine receptor strychnine-binding subunit)
- Gene biotype
- Protein coding
- Gene family
- Glycine receptors
- Target class
- Ion channel
- Target type
- Human gene
- Tissues expressed in
- 0
- Protein localisation evidence grade
- Approved
- Highest tissue expression
- 0.81
- Tissue specificity (Gini)
- 0.764
- Tissue specificity (tau)
- 0.94
- KEGG gene identifiers
- hsa:2741
- Reactome pathways
- R-HSA-112314
- Protein interaction confidence
- 0.8335
- Protein interaction partners
- 6
- End position
- 151924851
- Start position
- 151822513
- Chromosome
- 5
- Strand
- Reverse
- Postsynaptic cell membrane
- Multi-pass membrane protein . Synapse . Perikaryon . Cell projection, dendrite . Cell membrane
- Multi-pass membrane protein .
- Plasma membrane
- PubMed 14551753
- PubMed 16144831
- PubMed 2155780
- PubMed 22715885
- PubMed 22973015
- PubMed 24108130
- PubMed 25445488
- PubMed 25730860
- PubMed 25973519
- PubMed 7920629
- PubMed 7925268
- PubMed 9009272
- PubMed 23994010
- Tissue specificity (tau)
- 0.940368
- Expression inequality (Gini)
- 0.764315
Expression in transcripts per million
- Brain - Hypothalamus
- 0.81
- Brain - Substantia nigra
- 0.57
- Brain - Cerebellum
- 0.31
- Brain - Cerebellar Hemisphere
- 0.31
- Brain - Spinal cord (cervical c-1)
- 0.25
Expression in transcripts per million
- Brain - Hypothalamus0.81
- Brain - Substantia nigra0.57
- Brain - Cerebellum0.31
- Brain - Cerebellar Hemisphere0.31
- Brain - Spinal cord (cervical c-1)0.25
- Brain - Putamen (basal ganglia)0.13
- Pancreas0.08
- Testis0.08
- Brain - Caudate (basal ganglia)0.07
- Brain - Frontal Cortex (BA9)0.06
- Brain - Cortex0.06
- Fallopian Tube0.05
- Brain - Amygdala0.05
- Brain - Nucleus accumbens (basal ganglia)0.04
- Brain - Anterior cingulate cortex (BA24)0.04
- Nerve - Tibial0.03
- Cells - Cultured fibroblasts0.03
- Thyroid0.03
- Cells - EBV-transformed lymphocytes0.03
- Adrenal Gland0.03
- Brain - Hippocampus0.02
- Lung0.02
- Muscle - Skeletal0.02
- Adipose - Visceral (Omentum)0.02
- Artery - Coronary0.02
And 29 more, listed on the interactive page.
- GO:0001964
- GO:0006811
- GO:0006821
- GO:0006936
- GO:0007218
- GO:0042391
- GO:0051970
- GO:0071230
- GO:0071294
- GO:0071361
- GO:1902476
- GO:2000344
- GO:0005886
- GO:0043231
- GO:0005515
- GO:0008270
- GO:0016594
- GO:0016934
- GO:0030977
- GO:0099507
Related records
Trials (1,359)
- 1-1-8 Wash-in for Sevoflurane Low Flow Anesthesia
- 3 mL Inhaled Methoxyflurane for Intrauterine Device (IUD) Insertion
- 50% Effective Concentration of Sevoflurane for Immobility
- A Comparison Between Oral Melatonin With Nasal Sevoflurane Versus Oral Chloral Hydrate With Nasal Sevoflurane in Sedation of Children Undergoing Brain MRI
- A Comparison of Desflurane vs. Sevoflurane and the Time to Awakening and the Incidence and Severity of Cough
- A Comparison of Emergence Agitation by Sevoflurane for Intraoperative Sedation Associated With Caudal Block
- A Comparison of Kidney Function After Nephrectomy in Living Donors Under Sevoflurane and Desflurane Anesthesia
- A Comparison of Propofol Based Total Intravenous Anesthesia and Desflurane Based Balanced Anesthesia on Hepatic Protection During Living-donor Liver Transplantation
- A Comparison of Propofol Based Total Intravenous Anesthesia and Desflurane Based Balanced Anesthesia on Renal Protection During Deceased Brain Dead Donor Kidney Transplantation - A Prospective, Randomized Trial
- A Comparison of Propofol Based Total Intravenous Anesthesia and Sevoflurane Based Balanced Anesthesia on Renal Protection During Lung Transplantation Under Extracorporeal Membrane Oxygenation - A Prospective, Randomized Trial
- A Comparison of Three Regimens of Acute Pain Management: Methoxyflurane; Intranasal Fentanyl; Intravenous Morphine
- A Comparison of Two Anaesthetic Methods of Protecting Heart Tissue During Cardiac Surgery
- A Drug-Food Interaction Study Between Colchicine and Grapefruit Juice
- A Laboratory Model of Increasing Delta-9-tetrahydrocannabinol (THC) Potency on Cigarette Smoking
- A Ph2, Colchicine For Inflammatory Carotid Injury And Disease Evolution After Radiotherapy
- A Pharmacokinetic Study of Colchicine With an Oral Contraceptive
- A Phase 4 Safety and Efficacy Study to Evaluate Lesinurad 200 mg in Participants With Gout and Renal Impairment
- A Phase I/II Study to Evaluate Single Agent and Combination Therapy With Megestrol Acetate and Dronabinol for the Treatment of HIV-Wasting Syndrome
- A Pilot Study for PK/PD Parameter of Colchicine in Chronic Kidney Disease Patient.
- A Pilot Study of Dronabinol for Adult Patients With Primary Gliomas
Drugs (12)
- Colchicine
- Desflurane Glycine receptor (alpha-1/beta) positive modulator
- Dronabinol
- Enflurane Glycine receptor (alpha-1/beta) positive modulator
- Halothane Glycine receptor (alpha-1/beta) positive modulator
- Isoflurane Glycine receptor (alpha-1/beta) positive modulator
- Methoxyflurane Glycine receptor (alpha-1/beta) agonist
- Nifedipine
- Onternabez
- Sevoflurane Glycine receptor (alpha-1/beta) positive modulator
- Strychnine
- Tropisetron