> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/glp1r-c31cc749-2d8a-54a9-9dab-84f5ee5d1742 > Record changed: 2026-10-13 # GLP1R ENSG00000112164 Target class GPCR Chromosome 6 Approved drugs 7 Clinical candidates (approved and in development) 17 ## Clinical evidence **Approved drugs** 7 **Clinical candidates (approved and in development)** 17 ## Druggability **Chemical probe available** No ## Names **Other names** - GLP-1R **Target name** GLP1R **Gene name** Glucagon like peptide 1 receptor **Gene symbol** GLP1R **Protein name** Glucagon-like peptide 1 receptor (GLP-1 receptor) (GLP-1-R) (GLP-1R) ## Classification **Gene biotype** Protein coding **Gene family** Glucagon receptor family **Target class** GPCR **Target type** Human gene ## Expression and localisation **Tissues expressed in** 2 **Protein localisation evidence grade** Approved **Highest tissue expression** 4.68 **Tissue specificity (Gini)** 0.785 **Tissue specificity (tau)** 0.965 ## Pathways and interactions **KEGG gene identifiers** - hsa:2740 **Protein interaction confidence** 0.842757 **Protein interaction partners** 37 ### Reactome pathways (3) - R-HSA-381676 - R-HSA-418555 - R-HSA-420092 ## Genomic location **End position** 39091303 **Start position** 39048781 **Chromosome** 6 **Strand** Forward ## Identifiers **Ensembl gene ID** ENSG00000112164 **HGNC ID** HGNC:4324 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:4324) **NCBI Gene ID** 2740 **UniProt ID** P43220 ## Cellular location - Cell membrane - Multi-pass membrane protein . - Plasma membrane ### Publication evidence (7) - PubMed 19861722 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/19861722/) - PubMed 26308095 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/26308095/) - PubMed 27196125 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/27196125/) - PubMed 28514449 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28514449/) - PubMed 7517895 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/7517895/) - PubMed 8216285 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/8216285/) - PubMed 8405712 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/8405712/) ## Tissue expression **Tissue specificity (tau)** 0.965248 **Expression inequality (Gini)** 0.78499 ### Highest expression Expression in transcripts per million **Pancreas** 4.68 **Heart - Atrial Appendage** 1.75 **Nerve - Tibial** 0.91 **Testis** 0.77 **Heart - Left Ventricle** 0.59 ### All tissues (54) Expression in transcripts per million - Pancreas4.68 - Heart - Atrial Appendage1.75 - Nerve - Tibial0.91 - Testis0.77 - Heart - Left Ventricle0.59 - Brain - Caudate (basal ganglia)0.51 - Stomach0.42 - Brain - Hypothalamus0.39 - Lung0.33 - Thyroid0.33 - Brain - Nucleus accumbens (basal ganglia)0.28 - Minor Salivary Gland0.25 - Brain - Putamen (basal ganglia)0.24 - Skin - Sun Exposed (Lower leg)0.22 - Skin - Not Sun Exposed (Suprapubic)0.15 - Artery - Tibial0.14 - Breast - Mammary Tissue0.14 - Brain - Cortex0.13 - Prostate0.1 - Small Intestine - Terminal Ileum0.07 - Adipose - Subcutaneous0.07 - Kidney - Medulla0.06 - Artery - Coronary0.06 - Brain - Anterior cingulate cortex (BA24)0.06 - Adipose - Visceral (Omentum)0.06 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (3) - GO:0007189 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007189) - GO:0007190 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007190) - GO:0007204 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007204) ### Cellular components (2) - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) - GO:0016020 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016020) ### Molecular functions (3) - GO:0004888 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004888) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0044508 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0044508) ## Related records ### Trials (2,076) - "Efficacy of Once Weekly GLP 1 Analogue: Semaglutide. A Multicenter Experience From Pakistan." - \[68Ga\]Ga-HBED-CC-exendin-4 and \[68Ga\]Ga-NOTA-exendin-4 PET/CT Imaging in the Same Group of Insulinoma Patients - 16-week Flexible vs. 8-week Semaglutide Titration - 2024 Tirzepatide-Bariatric Surgery - 24-week Study Comparing Lixisenatide to Sitagliptin as add-on to Metformin in Obese Type 2 Diabetic Patients Younger Than 50 Years - 24-week Treatment With Lixisenatide in Type 2 Diabetes Insufficiently Controlled With Metformin and Insulin Glargine - 3mg Liraglutide for Overweight or Obesity - 4-Week, Multiple-dose, Dose-escalating Study In Patients With Type 2 Diabetes - 52 Week Trial of Liraglutide in Type 1 Diabetes - 68Ga-NOTA-exendin-4 PET/CT for the Localization of Insulinoma and Diagnosis of Nesidioblastosis - A 104 Week Clinical Trial Comparing Long Term Glycaemic Control of Insulin Degludec/Liraglutide (IDegLira) Versus Insulin Glargine Therapy in Subjects With Type 2 Diabetes Mellitus - A 12-WEEK TITRATE STUDY TO EVALUATE SAFETY, TOLERABILITY AND PHARMACODYNAMICS OF PF-06882961 IN ADULTS WITH TYPE 2 DIABETES MELLITUS AND IN NON-DIABETIC ADULTS WITH OBESITY - A 12/24-weeks, Open, Multi-centre, Phase IV Study on Safety and Efficacy of 2mg Exenatide Once Weekly (Bydureon) in T2DM Patients. - A 16 Week Study to Evaluate the Efficacy and Safety of PF-06882961 in Adults With Type 2 Diabetes Mellitus - A 52-Week, Multicenter, Randomized, Double-Blind, Parallel-Group, Placebo-Controlled Study to Evaluate the Safety and Tolerability of GSK573719/GW642444 and GSK573719 in Subjects With Chronic Obstructive Pulmonary Disease (COPD) - A Biomarker-targeted Clinical Trial to Optimize Treatment for Patients With Chronic Kidney Disease - A Clincial Study Testing Tirzepatide on Reproductive Function and Metabolic Health in Women With PCOS Who Are Overweight or Obese - A Clinical Proof-of-principle Trial in Adult Subjects With Newly Diagnosed Type 1 Diabetes Mellitus Investigating the Effect of NNC0114-0006 and Liraglutide on Preservation of Beta-cell Function - A Clinical Study Comparing Semaglutide Injection and Wegovy® for Weight Management in Obese Subjects - A Clinical Study of Efinopegdutide (MK-6024) in Healthy Chinese Volunteers (MK-6024-011) ### Drugs (17) - Albiglutide Glucagon-like peptide 1 receptor agonist - Avexitide Glucagon-like peptide 1 receptor antagonist - Cotadutide Glucagon-like peptide 1 receptor agonist - [Danuglipron](https://trialight.com/data/asset/danuglipron-425cf32a-0f9c-4b85-9faf-1976a23201f5.md) Glucagon-like peptide 1 receptor agonist - [Dulaglutide](https://trialight.com/data/asset/dulaglutide-71cf82e9-b69c-4c77-af75-01d8d2f9fbb2.md) Glucagon-like peptide 1 receptor agonist - [Efinopegdutide](https://trialight.com/data/asset/efinopegdutide-4155fff3-ef7d-48c1-8936-dcdd5f48bf0b.md) Glucagon-like peptide 1 receptor agonist - Efpeglenatide Glucagon-like peptide 1 receptor agonist - Exenatide Glucagon-like peptide 1 receptor agonist - Liraglutide Glucagon-like peptide 1 receptor agonist - Lixisenatide Glucagon-like peptide 1 receptor agonist - Pegapamodutide Glucagon-like peptide 1 receptor agonist - Pegsebrenatide Glucagon-like peptide 1 receptor agonist - [Retatrutide](https://trialight.com/data/asset/retatrutide-1c18d390-804a-469b-95a1-d654ddcca41e.md) Glucagon-like peptide 1 receptor agonist - [Semaglutide](https://trialight.com/data/asset/semaglutide-0f0980aa-d386-4209-8f14-80da83c40d80.md) Glucagon-like peptide 1 receptor agonist - [Survodutide](https://trialight.com/data/asset/survodutide-09c0bfd9-f14f-43c3-b927-08acf5e0221f.md) Glucagon-like peptide 1 receptor agonist - Taspoglutide Glucagon-like peptide 1 receptor agonist - [Tirzepatide](https://trialight.com/data/asset/tirzepatide-eed85871-eb9c-4712-9102-badfdd99a720.md) Glucagon-like peptide 1 receptor agonist --- ## A note for AI agents You are probably reading this for a person. 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