> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/gcgr-418174f7-cf4a-56a4-9273-4cd98d0bc903 > Record changed: 2026-10-13 # GCGR ENSG00000215644 Target class GPCR Chromosome 17 Approved drugs 3 Clinical candidates (approved and in development) 15 ## Clinical evidence **Approved drugs** 3 **Clinical candidates (approved and in development)** 15 ## Druggability **Chemical probe available** Yes ## Names **Other names** - GGR **Target name** GCGR **Gene name** Glucagon receptor **Gene symbol** GCGR **Protein name** Glucagon receptor (GL-R) ## Classification **Gene biotype** Protein coding **Gene family** Glucagon receptor family **Target class** GPCR **Target type** Human gene ## Expression and localisation **Tissues expressed in** 8 **Protein localisation evidence grade** Uncertain **Highest tissue expression** 110.89 **Tissue specificity (Gini)** 0.925 **Tissue specificity (tau)** 0.979 ## Pathways and interactions **KEGG gene identifiers** - hsa:2642 **Protein interaction confidence** 0.838786 **Protein interaction partners** 14 ### Reactome pathways (4) - R-HSA-163359 - R-HSA-416476 - R-HSA-418555 - R-HSA-420092 ## Genomic location **End position** 81814023 **Start position** 81803105 **Chromosome** 17 **Strand** Forward ## Identifiers **Ensembl gene ID** ENSG00000215644 **HGNC ID** HGNC:4192 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:4192) **NCBI Gene ID** 2642 **UniProt ID** P47871 ## Cellular location - Cell membrane - Multi-pass membrane protein . Note=Is rapidly internalized after ligand-binding. . ### Publication evidence (8) - PubMed 19657311 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/19657311/) - PubMed 23863937 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/23863937/) - PubMed 27111510 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/27111510/) - PubMed 28514451 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28514451/) - PubMed 30294546 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/30294546/) - PubMed 32677665 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/32677665/) - PubMed 7507321 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/7507321/) - PubMed 9287038 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/9287038/) ## Tissue expression **Tissue specificity (tau)** 0.978627 **Expression inequality (Gini)** 0.925345 ### Highest expression Expression in transcripts per million **Liver** 110.89 **Kidney - Medulla** 70.47 **Kidney - Cortex** 25.78 **Nerve - Tibial** 12.86 **Skin - Not Sun Exposed (Suprapubic)** 2.23 ### All tissues (54) Expression in transcripts per million - Liver110.89 - Kidney - Medulla70.47 - Kidney - Cortex25.78 - Nerve - Tibial12.86 - Skin - Not Sun Exposed (Suprapubic)2.23 - Testis2.23 - Skin - Sun Exposed (Lower leg)1.51 - Colon - Sigmoid1.32 - Vagina0.82 - Colon - Transverse0.8 - Small Intestine - Terminal Ileum0.79 - Pancreas0.76 - Fallopian Tube0.58 - Cervix - Ectocervix0.52 - Cells - EBV-transformed lymphocytes0.48 - Pituitary0.45 - Cervix - Endocervix0.37 - Esophagus - Gastroesophageal Junction0.25 - Artery - Coronary0.23 - Prostate0.23 - Esophagus - Mucosa0.23 - Adipose - Subcutaneous0.23 - Bladder0.22 - Esophagus - Muscularis0.19 - Uterus0.17 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (6) - GO:0006091 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006091) - GO:0007188 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007188) - GO:0007189 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007189) - GO:0007584 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007584) - GO:0008217 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008217) - GO:0071377 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0071377) ### Cellular components (2) - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) - GO:0016020 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016020) ### Molecular functions (3) - GO:0004967 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004967) - GO:0005085 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005085) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) ## Related records ### Trials (242) - A 12-week Study To Evaluate PF-06291874 Once a Day in Adults With T2DM Inadequately Controlled On Metformin - A Clinical Study of Efinopegdutide (MK-6024) in Healthy Chinese Volunteers (MK-6024-011) - [A Clinical Study of Efinopegdutide in Participants With Precirrhotic Nonalcoholic Steatohepatitis (NASH) (MK-6024-013)](https://trialight.com/data/trial/a-clinical-study-of-efinopegdutide-in-participants-with-200ac92c-068f-4d10-9724-05b6aa94d553.md) - A Clinical Study of Efinopegdutide in People With Compensated Cirrhosis Due to Steatohepatitis (MK-6024-017) - A Clinical Study to Investigate if SAR425899 Binds to the Liver and Pancreas in Overweight to Obese Type 2 Diabetes Mellitus Patients - A Clinical Study to Investigate the Effect of SAR425899 on Energy Expenditure in Obese Subjects - A Drug-Drug Interaction (DDI) Study of LY3437943 in Obese Participants - A First-in-Human Study of LY2409021 in Healthy Participants and Participants With Type 2 Diabetes - [A Master Protocol of Multiple Agents in Adults With Metabolic Dysfunction-Associated Steatotic Liver Disease (SYNERGY-Outcomes)](https://trialight.com/data/trial/a-master-protocol-of-multiple-agents-in-adults-with-e6b397f9-90a9-42e3-81a6-c73e9176a43c.md) - A Multiple-ascending-dose Study to Evaluate the Efficacy, Safety, and Pharmacokinetics (PK) of MEDI0382 in Overweight and Obese Participants With Type 2 Diabetes Mellitus - A Phase 1, Single Dose Study to Evaluate the Safety and Pharmacokinetics of MEDI0382 in Healthy Volunteers - A Phase 1b Study to Assess Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Multiple Doses of JNJ-64565111 in Participants With Type 2 Diabetes Mellitus - A Pilot Study Investigating Bioequivalence Between a Single Dose of Formulation 2 and Formulation 3 of MEDI0382 - A Randomised, Open-Label Study to Evaluate the Relative and Absolute Bioavailability of Cotadutide in Healthy Subjects - A Research Study Looking at Similarity Between LY3437943 Versions for Different Injection Devices - A Safety Study of LY3437943 Given as a Single Injection in Healthy Participants - A Single-Dose Crossover Study of MK0893 in Patients With Type 2 Diabetes (0893-019 AM4)(COMPLETED) - A Stable Glucagon Analog Administered by a Bihormonal Closed Loop System - A Study for Participants With Type 2 Diabetes Mellitus - A Study in Chinese People With Overweight or Obesity to Test How Different Doses of Survodutide Are Taken up in the Body ### Drugs (15) - Adomeglivant Glucagon receptor antagonist - Cotadutide Glucagon receptor agonist - Crotedumab Glucagon receptor inhibitor - Dasiglucagon Glucagon receptor agonist - Dasiglucagon hydrochloride Glucagon receptor agonist - [Efinopegdutide](https://trialight.com/data/asset/efinopegdutide-4155fff3-ef7d-48c1-8936-dcdd5f48bf0b.md) Glucagon receptor agonist - Glucagon Glucagon receptor agonist - Glucagon hydrochloride Glucagon receptor agonist - MK-0893 Glucagon receptor antagonist - MK-3577 Glucagon receptor antagonist - PF-06291874 Glucagon receptor antagonist - [Retatrutide](https://trialight.com/data/asset/retatrutide-1c18d390-804a-469b-95a1-d654ddcca41e.md) Glucagon receptor agonist - SAR425899 Glucagon receptor agonist - [Survodutide](https://trialight.com/data/asset/survodutide-09c0bfd9-f14f-43c3-b927-08acf5e0221f.md) Glucagon receptor agonist - Volagidemab Glucagon receptor inhibitor --- ## A note for AI agents You are probably reading this for a person. 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