> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/gart-01a731ec-9c88-556f-8fc6-2217fab015bc > Record changed: 2026-10-13 # GART ENSG00000159131 Target class Enzyme Chromosome 21 Approved drugs 5 Clinical candidates (approved and in development) 6 ## Clinical evidence **Approved drugs** 5 **Clinical candidates (approved and in development)** 6 ## Druggability **Chemical probe available** Yes ## Names **Other names** - GARS-AIRS-GART **Target name** GART **Gene name** Phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase **Gene symbol** GART **Protein name** Trifunctional purine biosynthetic protein adenosine-3 \[Includes: Phosphoribosylamine--glycine ligase (EC 6.3.4.13) (Glycinamide ribonucleotide synthetase) (GARS) (Phosphoribosylglycinamide synthetase); Phosphoribosylformylglycinamidine cyclo-ligase (EC 6.3.3.1) (AIR synthase) (AIRS) (Phosphoribosyl-aminoimidazole synthetase); Phosphoribosylglycinamide formyltransferase (EC 2.1.2.2) (5'-phosphoribosylglycinamide transformylase) (GAR transformylase) (GART)\] ### Previous gene symbols (2) - PRGS - PGFT ## Classification **Gene biotype** Protein coding **Gene family** Purinosome|ATP-grasp fold containing **Target class** Enzyme **Target type** Human gene ## Expression and localisation **Tissues expressed in** 54 **Protein localisation evidence grade** Approved **Highest tissue expression** 64.02 **Tissue specificity (Gini)** 0.284 **Tissue specificity (tau)** 0.729 ## Pathways and interactions **KEGG gene identifiers** - hsa:2618 **Reactome pathways** - R-HSA-73817 **Protein interaction confidence** 0.858988 **Protein interaction partners** 84 ## Genomic location **End position** 33543524 **Start position** 33503371 **Chromosome** 21 **Strand** Reverse ## Identifiers **Ensembl gene ID** ENSG00000159131 **HGNC ID** HGNC:4163 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:4163) **NCBI Gene ID** 2618 **UniProt ID** P22102 ## Cellular location - Cytosol - Mitochondria ## Tissue expression **Tissue specificity (tau)** 0.728917 **Expression inequality (Gini)** 0.283854 ### Highest expression Expression in transcripts per million **Cells - Cultured fibroblasts** 64.02 **Cells - EBV-transformed lymphocytes** 60.29 **Testis** 33.73 **Adipose - Subcutaneous** 25.75 **Adipose - Visceral (Omentum)** 25.14 ### All tissues (54) Expression in transcripts per million - Cells - Cultured fibroblasts64.02 - Cells - EBV-transformed lymphocytes60.29 - Testis33.73 - Adipose - Subcutaneous25.75 - Adipose - Visceral (Omentum)25.14 - Breast - Mammary Tissue24.72 - Nerve - Tibial24.35 - Esophagus - Mucosa24.32 - Uterus24.11 - Bladder23.83 - Ovary23.42 - Fallopian Tube22.52 - Cervix - Ectocervix22.51 - Artery - Coronary22.29 - Vagina22.03 - Artery - Tibial21.84 - Thyroid21.49 - Spleen21.47 - Lung21.26 - Artery - Aorta21.18 - Cervix - Endocervix20.86 - Colon - Sigmoid19.6 - Esophagus - Muscularis19.45 - Skin - Sun Exposed (Lower leg)19.33 - Small Intestine - Terminal Ileum18.88 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (5) - GO:0006177 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006177) - GO:0006189 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006189) - GO:0009168 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0009168) - GO:0044208 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0044208) - GO:0097294 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0097294) ### Cellular components (2) - GO:0005829 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005829) - GO:0070062 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070062) ### Molecular functions (3) - GO:0004637 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004637) - GO:0004641 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004641) - GO:0004644 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004644) ## Related records ### Trials (1,073) - (Concerto) Study of BLU-451 in Advanced Cancers With EGFR Exon 20 Insertion Mutations - (HARMONY) Study of BLU-701 in EGFR-mutant NSCLC - A Clinical and Molecular Risk-Directed Therapy for Newly Diagnosed Medulloblastoma - A Clinical Study of Bemcentinib With Standard of Care Chemoimmunotherapy in Untreated Advanced/Metastatic Non-small Cell Lung Cancer Patients With a Mutation in the STK11 Gene - A Clinical Study of Calderasib (MK-1084) and Other Treatments for Participants With Non-Small Cell Lung Cancer (MK-1084-007/KANDLELIT-007) - A Clinical Study on the Safety and Efficacy of Debio 0932 in Combination With Standard of Care in Patients With Non-small Cell Lung Cancer \[NSCLC\] - A Clinical Study to Evaluate the Safety and Tolerability of AWT020 in Patients With Advanced Malignancies - A Clinical Trial of LBL-024 Combination Drug in Patients With Advanced Solid Tumours\[Substudy 01(NSCLC)\] - A Clinical Trial of TQB2450 Injection Combined With AL2846 Capsules in Patients With Advanced Solid Tumors - A Comparison of Two Doses of Pemetrexed in Patients Who Have Lung Cancer - A Drug Interaction Study to Assess the Effect of LY2603618 on the Metabolic Pathway of Desipramine - A Efficacy and Safety Study of Anlotinib Hydrochloride Capsule Combined With Chemotherapy Versus Placebo Combined With Chemotherapy as First-line Treatment in Subjects With Advanced Non-squamous Cell Non-small Cell Lung Cancer - A First-in-Human Study of CAN04 in Patients With Solid Malignant Tumors - [A Global Phase III Study of Rilvegostomig or Pembrolizumab Plus Chemotherapy for First-Line Treatment of Locally Advanced or Metastatic Non-Squamous NSCLC](https://trialight.com/data/trial/a-global-phase-iii-study-of-rilvegostomig-or-pembrolizumab-2214dc53-fd67-4cf8-80fd-2e328685ed0a.md) - A Global Study of Volrustomig (MEDI5752) Plus Chemotherapy Versus Pembrolizumab Plus Chemotherapy for Participants With Metastatic Non-small Cell Lung Cancer. - A Multi-cohort Study of Efbemalenograstim Alfa Injection for Preventing ANC Reduction in Solid Tumor Patients Post Immune-chemotherapy. - A Multicenter Exploratory Clinical Study of Iruplaltinib Combined With Pemetrexed as Neoadjuvant Therapy for Resectable ALK-Positive Non-Squamous Non-Small Cell Lung Cancer - A Neoadjuvant Study of Nivolumab Plus Ipilimumab or Nivolumab Plus Chemotherapy Versus Chemotherapy Alone in Early Stage Non-Small Cell Lung Cancer (NSCLC) - A Personal Cancer Vaccine (NEO-PV-01) With Pembrolizumab and Chemotherapy for Patients With Lung Cancer - A Phase 1 Study in Patients With Solid Tumors ### Drugs (6) - Pelitrexol GAR transformylase inhibitor - [Pemetrexed](https://trialight.com/data/asset/pemetrexed-2221859e-676b-4d76-97df-e11f3f9664a1.md) GAR transformylase inhibitor - Pemetrexed dipotassium GAR transformylase inhibitor - [Pemetrexed disodium](https://trialight.com/data/asset/pemetrexed-disodium-c80fe85f-320e-4817-87cb-0c8bbcbe8967.md) GAR transformylase inhibitor - Pemetrexed monohydrate GAR transformylase inhibitor - Pemetrexed tromethamine GAR transformylase inhibitor --- ## A note for AI agents You are probably reading this for a person. 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