GABRG3
ENSG00000182256
Target class
Ion channel
Chromosome
15
Approved drugs
55
Clinical candidates (approved and in development)
66
- Approved drugs
- 55
- Clinical candidates (approved and in development)
- 66
- Chemical probe available
- No
- Target name
- GABRG3
- Gene name
- Gamma-aminobutyric acid type A receptor subunit gamma3
- Gene symbol
- GABRG3
- Protein name
- Gamma-aminobutyric acid receptor subunit gamma-3 (GABA(A) receptor subunit gamma-3) (GABAAR subunit gamma-3)
- Gene biotype
- Protein coding
- Gene family
- Gamma-aminobutyric acid type A receptor subunits
- Target class
- Ion channel
- Target type
- Human gene
- Tissues expressed in
- 7
- Protein localisation evidence grade
- Approved
- Highest tissue expression
- 2.48
- Tissue specificity (Gini)
- 0.791
- Tissue specificity (tau)
- 0.889
- KEGG gene identifiers
- hsa:2567
- Protein interaction confidence
- 0.797789
- Protein interaction partners
- 19
- R-HSA-1236394
- R-HSA-977443
- End position
- 27541984
- Start position
- 26971181
- Chromosome
- 15
- Strand
- Forward
- Postsynaptic cell membrane
- Multi-pass membrane protein . Cell membrane
- Multi-pass membrane protein .
- Plasma membrane
- Tissue specificity (tau)
- 0.888923
- Expression inequality (Gini)
- 0.790528
Expression in transcripts per million
- Brain - Hypothalamus
- 2.48
- Brain - Frontal Cortex (BA9)
- 2.03
- Testis
- 1.89
- Pituitary
- 1.76
- Brain - Cortex
- 1.52
Expression in transcripts per million
- Brain - Hypothalamus2.48
- Brain - Frontal Cortex (BA9)2.03
- Testis1.89
- Pituitary1.76
- Brain - Cortex1.52
- Brain - Nucleus accumbens (basal ganglia)1.26
- Brain - Anterior cingulate cortex (BA24)1.06
- Brain - Cerebellum0.88
- Brain - Caudate (basal ganglia)0.67
- Prostate0.59
- Brain - Putamen (basal ganglia)0.47
- Brain - Hippocampus0.47
- Brain - Amygdala0.45
- Brain - Cerebellar Hemisphere0.42
- Spleen0.25
- Brain - Substantia nigra0.15
- Minor Salivary Gland0.13
- Skin - Sun Exposed (Lower leg)0.1
- Kidney - Medulla0.07
- Brain - Spinal cord (cervical c-1)0.07
- Cervix - Ectocervix0.07
- Vagina0.06
- Skin - Not Sun Exposed (Suprapubic)0.05
- Thyroid0.04
- Cervix - Endocervix0.02
And 29 more, listed on the interactive page.
Cellular components
- GO:0005886
decreased cardiac contractility
Effects
- Activation/Increase/Upregulation: acute
Studies
- preclinical: decreased cardiac contractility
- central nervous system
- cardiovascular
PubMed 28216264drug abuse/dependence
Effects
- Activation/Increase/Upregulation: acute
Studies
- preclinical: drug abuse/dependence
- central nervous system
- cardiovascular
PubMed 28216264decreased memory
Effects
- Activation/Increase/Upregulation: acute
Studies
- preclinical: decreased memory
- central nervous system
- cardiovascular
PubMed 28216264decreased sleep
Effects
- Inhibition/Decrease/Downregulation: acute
Studies
- preclinical: decreased sleep
- central nervous system
- cardiovascular
PubMed 28216264decreased convulsions
Effects
- Activation/Increase/Upregulation: acute
Studies
- preclinical: decreased convulsions
- central nervous system
- cardiovascular
PubMed 28216264decreased locomotor activity
Effects
- Activation/Increase/Upregulation: acute
Studies
- preclinical: decreased locomotor activity
- central nervous system
- cardiovascular
PubMed 28216264increased eating
Effects
- Activation/Increase/Upregulation: acute
Studies
- preclinical: increased eating
- central nervous system
- cardiovascular
PubMed 28216264decreased blood pressure
Effects
- Activation/Increase/Upregulation: acute
Studies
- preclinical: decreased blood pressure
- central nervous system
- cardiovascular
PubMed 28216264muscle relaxation
Effects
- Activation/Increase/Upregulation: acute
Studies
- preclinical: muscle relaxation
- central nervous system
- cardiovascular
PubMed 28216264decreased body temperature
Effects
- Activation/Increase/Upregulation: acute
Studies
- preclinical: decreased body temperature
- central nervous system
- cardiovascular
PubMed 28216264decreased pain
Effects
- Activation/Increase/Upregulation: acute
Studies
- preclinical: decreased pain
- central nervous system
- cardiovascular
PubMed 28216264convulsions
Effects
- Inhibition/Decrease/Downregulation: acute
Studies
- preclinical: convulsions
- central nervous system
- cardiovascular
PubMed 28216264decreased anxiety
Effects
- Activation/Increase/Upregulation: acute
Studies
- preclinical: decreased anxiety
- central nervous system
- cardiovascular
PubMed 28216264ataxia
Effects
- Activation/Increase/Upregulation: acute
Studies
- preclinical: ataxia
- central nervous system
- cardiovascular
PubMed 28216264increased respiratory rate
Effects
- Activation/Increase/Upregulation: acute
Studies
- preclinical: increased respiratory rate
- central nervous system
- cardiovascular
PubMed 28216264increased cardiac output
Effects
- Activation/Increase/Upregulation: acute
Studies
- preclinical: increased cardiac output
- central nervous system
- cardiovascular
PubMed 28216264increased sleep
Effects
- Activation/Increase/Upregulation: acute
Studies
- preclinical: increased sleep
- central nervous system
- cardiovascular
PubMed 28216264
Related records
Trials (3,869)
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- A Clinical Drug-Drug Interaction (DDI) Study With Omaveloxolone
- A Clinical Study Evaluating Sedation of Intravenous Administration of HSK3486 in ICU Patients Undergoing Long-Term Mechanical Ventilation
- A Clinical Study of Remimazolam Tosilate Compared to Propofol for General Anesthesia During Elective Surgery
- A Clinical Study of Remimazolam Tosilate in Patients Undergoing Bronchoscopy
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Drugs (76)
- ABP-700 GABA-A receptor; anion channel agonist
- Acamprosate GABA-A receptor; anion channel positive modulator
- Acamprosate calcium GABA-A receptor; anion channel positive modulator
- Adipiplon GABA-A receptor; anion channel partial agonist
- Alprazolam GABA-A receptor; anion channel positive allosteric modulator
- Brexanolone GABA-A receptor; anion channel positive allosteric modulator
- Butabarbital GABA-A receptor; anion channel positive allosteric modulator
- Butabarbital sodium GABA-A receptor; anion channel positive allosteric modulator
- Butalbital GABA-A receptor; anion channel positive allosteric modulator
- Cenobamate GABA-A receptor; anion channel positive allosteric modulator
- Chlordiazepoxide GABA-A receptor; anion channel positive allosteric modulator
- Chlordiazepoxide hydrochloride GABA-A receptor; anion channel positive allosteric modulator
- Cipepofol GABA-A receptor; anion channel agonist
- Clobazam GABA-A receptor; anion channel positive allosteric modulator
- Clomethiazole GABA-A receptor; anion channel positive allosteric modulator
- Clonazepam GABA-A receptor; anion channel positive allosteric modulator
- Clorazepate dipotassium GABA-A receptor; anion channel positive allosteric modulator
- Clorazepic acid GABA-A receptor; anion channel positive allosteric modulator
- Clotiazepam GABA-A receptor; anion channel positive allosteric modulator
- Darigabat GABA-A receptor; anion channel agonist