> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/gabre-38203809-e856-5ed9-b0df-ad994e506211 > Record changed: 2026-10-13 # GABRE ENSG00000102287 Target class Ion channel Chromosome X Approved drugs 55 Clinical candidates (approved and in development) 66 ## Clinical evidence **Approved drugs** 55 **Clinical candidates (approved and in development)** 66 ## Druggability **Chemical probe available** No ## Names **Target name** GABRE **Gene name** Gamma-aminobutyric acid type A receptor subunit epsilon **Gene symbol** GABRE **Protein name** Gamma-aminobutyric acid receptor subunit epsilon (GABA(A) receptor subunit epsilon) (GABAAR subunit epsilon) ## Classification **Gene biotype** Protein coding **Gene family** Gamma-aminobutyric acid type A receptor subunits|MicroRNA protein coding host genes **Target class** Ion channel **Target type** Human gene ## Expression and localisation **Tissues expressed in** 47 **Highest tissue expression** 111.28 **Tissue specificity (Gini)** 0.595 **Tissue specificity (tau)** 0.806 ## Pathways and interactions **KEGG gene identifiers** - hsa:2564 **Protein interaction confidence** 0.794063 **Protein interaction partners** 16 ## Genomic location **End position** 151974680 **Start position** 151953124 **Chromosome** X **Strand** Reverse ## Identifiers **Ensembl gene ID** ENSG00000102287 **HGNC ID** HGNC:4085 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:4085) **NCBI Gene ID** 2564 **UniProt ID** P78334 ## Cellular location - Cell membrane - Multi-pass membrane protein . Postsynaptic cell membrane - Multi-pass membrane protein . ## Tissue expression **Tissue specificity (tau)** 0.806312 **Expression inequality (Gini)** 0.594538 ### Highest expression Expression in transcripts per million **Vagina** 111.28 **Adipose - Subcutaneous** 90.29 **Cervix - Endocervix** 87.48 **Cervix - Ectocervix** 82.57 **Adipose - Visceral (Omentum)** 81.33 ### All tissues (54) Expression in transcripts per million - Vagina111.28 - Adipose - Subcutaneous90.29 - Cervix - Endocervix87.48 - Cervix - Ectocervix82.57 - Adipose - Visceral (Omentum)81.33 - Prostate74.5 - Esophagus - Mucosa59.35 - Breast - Mammary Tissue53.02 - Skin - Not Sun Exposed (Suprapubic)50.54 - Thyroid39.33 - Skin - Sun Exposed (Lower leg)36.38 - Minor Salivary Gland33.69 - Uterus31.81 - Artery - Tibial31.78 - Fallopian Tube30.62 - Nerve - Tibial30.28 - Bladder29.06 - Lung28.85 - Small Intestine - Terminal Ileum28.11 - Artery - Aorta22.93 - Kidney - Medulla20.25 - Cells - Cultured fibroblasts17.99 - Spleen17.82 - Artery - Coronary17.34 - Ovary16.89 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes - GO:2001226 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:2001226) ### Cellular components - GO:1902711 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1902711) ### Molecular functions (2) - GO:0004890 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004890) - GO:0022851 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0022851) ## Related records ### Trials (3,869) - "Chou's Tiaoshen" Acupoints for Short-term Insomnia. - "Volatile Anesthetic Protection Of Renal Transplants: VAPOR-1-trail - (Peak) A Phase 3 Randomized Trial of CGT9486+Sunitinib vs. Sunitinib in Subjects With Gastrointestinal Stromal Tumors - \[18F\]Fluciclovine in Post-treatment Glioblastoma ( Axumin ) - 1-1-8 Wash-in for Sevoflurane Low Flow Anesthesia - 12-Month Real-World Safety & Efficacy of Lecanemab in Early Alzheimer's Disease - 28-day Repeat Dose and Drug Interaction Study With Orvepitant (GW823296) - 3 mL Inhaled Methoxyflurane for Intrauterine Device (IUD) Insertion - 50% Effective Concentration of Sevoflurane for Immobility - 6-Month Chronic Efficacy & Safety Study of Eszopiclone in Adult Subjects With Primary Insomnia - A 2-Part Study to Assess Potential Metabolism-Based Drug-Drug Interactions of E2006 When Coadministered With Itraconazole, Rifampin, Midazolam, or Bupropion - A 5-Week Trial Of PD 0332334 And Alprazolam Extended Release Compared To Placebo In Patients With Generalized Anxiety Disorder - A Better Choice for Patients Undergoing Endovascular Coil Embolization - A Bioequivalence and Food Effect Study of SEP-190 in Japanese Healthy Subjects (Study SEP 190-102) - A Bioequivalence Study Of A New Alprazolam Dropped Formulation Versus Alprazolam Tablets - A Clinical Drug-Drug Interaction (DDI) Study With Omaveloxolone - A Clinical Study Evaluating Sedation of Intravenous Administration of HSK3486 in ICU Patients Undergoing Long-Term Mechanical Ventilation - A Clinical Study of Remimazolam Tosilate Compared to Propofol for General Anesthesia During Elective Surgery - A Clinical Study of Remimazolam Tosilate in Patients Undergoing Bronchoscopy - A Clinical Study to Determine the Safety, Tolerability and Effect of RLS-0071 Doses When Given to Healthy Adults After Inhaling LPS ### Drugs (76) - ABP-700 GABA-A receptor; anion channel agonist - Acamprosate GABA-A receptor; anion channel positive modulator - Acamprosate calcium GABA-A receptor; anion channel positive modulator - Adipiplon GABA-A receptor; anion channel partial agonist - Alprazolam GABA-A receptor; anion channel positive allosteric modulator - Brexanolone GABA-A receptor; anion channel positive allosteric modulator - Butabarbital GABA-A receptor; anion channel positive allosteric modulator - Butabarbital sodium GABA-A receptor; anion channel positive allosteric modulator - Butalbital GABA-A receptor; anion channel positive allosteric modulator - Cenobamate GABA-A receptor; anion channel positive allosteric modulator - Chlordiazepoxide GABA-A receptor; anion channel positive allosteric modulator - Chlordiazepoxide hydrochloride GABA-A receptor; anion channel positive allosteric modulator - Cipepofol GABA-A receptor; anion channel agonist - Clobazam GABA-A receptor; anion channel positive allosteric modulator - Clomethiazole GABA-A receptor; anion channel positive allosteric modulator - Clonazepam GABA-A receptor; anion channel positive allosteric modulator - Clorazepate dipotassium GABA-A receptor; anion channel positive allosteric modulator - Clorazepic acid GABA-A receptor; anion channel positive allosteric modulator - Clotiazepam GABA-A receptor; anion channel positive allosteric modulator - Darigabat GABA-A receptor; anion channel agonist --- ## A note for AI agents You are probably reading this for a person. 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