GABRE
ENSG00000102287
Target class
Ion channel
Chromosome
X
Approved drugs
55
Clinical candidates (approved and in development)
66
- Approved drugs
- 55
- Clinical candidates (approved and in development)
- 66
- Chemical probe available
- No
- Target name
- GABRE
- Gene name
- Gamma-aminobutyric acid type A receptor subunit epsilon
- Gene symbol
- GABRE
- Protein name
- Gamma-aminobutyric acid receptor subunit epsilon (GABA(A) receptor subunit epsilon) (GABAAR subunit epsilon)
- Gene biotype
- Protein coding
- Gene family
- Gamma-aminobutyric acid type A receptor subunits|MicroRNA protein coding host genes
- Target class
- Ion channel
- Target type
- Human gene
- Tissues expressed in
- 47
- Highest tissue expression
- 111.28
- Tissue specificity (Gini)
- 0.595
- Tissue specificity (tau)
- 0.806
- KEGG gene identifiers
- hsa:2564
- Protein interaction confidence
- 0.794063
- Protein interaction partners
- 16
- End position
- 151974680
- Start position
- 151953124
- Chromosome
- X
- Strand
- Reverse
- Cell membrane
- Multi-pass membrane protein . Postsynaptic cell membrane
- Multi-pass membrane protein .
- Tissue specificity (tau)
- 0.806312
- Expression inequality (Gini)
- 0.594538
Expression in transcripts per million
- Vagina
- 111.28
- Adipose - Subcutaneous
- 90.29
- Cervix - Endocervix
- 87.48
- Cervix - Ectocervix
- 82.57
- Adipose - Visceral (Omentum)
- 81.33
Expression in transcripts per million
- Vagina111.28
- Adipose - Subcutaneous90.29
- Cervix - Endocervix87.48
- Cervix - Ectocervix82.57
- Adipose - Visceral (Omentum)81.33
- Prostate74.5
- Esophagus - Mucosa59.35
- Breast - Mammary Tissue53.02
- Skin - Not Sun Exposed (Suprapubic)50.54
- Thyroid39.33
- Skin - Sun Exposed (Lower leg)36.38
- Minor Salivary Gland33.69
- Uterus31.81
- Artery - Tibial31.78
- Fallopian Tube30.62
- Nerve - Tibial30.28
- Bladder29.06
- Lung28.85
- Small Intestine - Terminal Ileum28.11
- Artery - Aorta22.93
- Kidney - Medulla20.25
- Cells - Cultured fibroblasts17.99
- Spleen17.82
- Artery - Coronary17.34
- Ovary16.89
And 29 more, listed on the interactive page.
Biological processes
- GO:2001226
Cellular components
- GO:1902711
- GO:0004890
- GO:0022851
Related records
Trials (3,869)
- "Chou's Tiaoshen" Acupoints for Short-term Insomnia.
- "Volatile Anesthetic Protection Of Renal Transplants: VAPOR-1-trail
- (Peak) A Phase 3 Randomized Trial of CGT9486+Sunitinib vs. Sunitinib in Subjects With Gastrointestinal Stromal Tumors
- [18F]Fluciclovine in Post-treatment Glioblastoma ( Axumin )
- 1-1-8 Wash-in for Sevoflurane Low Flow Anesthesia
- 12-Month Real-World Safety & Efficacy of Lecanemab in Early Alzheimer's Disease
- 28-day Repeat Dose and Drug Interaction Study With Orvepitant (GW823296)
- 3 mL Inhaled Methoxyflurane for Intrauterine Device (IUD) Insertion
- 50% Effective Concentration of Sevoflurane for Immobility
- 6-Month Chronic Efficacy & Safety Study of Eszopiclone in Adult Subjects With Primary Insomnia
- A 2-Part Study to Assess Potential Metabolism-Based Drug-Drug Interactions of E2006 When Coadministered With Itraconazole, Rifampin, Midazolam, or Bupropion
- A 5-Week Trial Of PD 0332334 And Alprazolam Extended Release Compared To Placebo In Patients With Generalized Anxiety Disorder
- A Better Choice for Patients Undergoing Endovascular Coil Embolization
- A Bioequivalence and Food Effect Study of SEP-190 in Japanese Healthy Subjects (Study SEP 190-102)
- A Bioequivalence Study Of A New Alprazolam Dropped Formulation Versus Alprazolam Tablets
- A Clinical Drug-Drug Interaction (DDI) Study With Omaveloxolone
- A Clinical Study Evaluating Sedation of Intravenous Administration of HSK3486 in ICU Patients Undergoing Long-Term Mechanical Ventilation
- A Clinical Study of Remimazolam Tosilate Compared to Propofol for General Anesthesia During Elective Surgery
- A Clinical Study of Remimazolam Tosilate in Patients Undergoing Bronchoscopy
- A Clinical Study to Determine the Safety, Tolerability and Effect of RLS-0071 Doses When Given to Healthy Adults After Inhaling LPS
Drugs (76)
- ABP-700 GABA-A receptor; anion channel agonist
- Acamprosate GABA-A receptor; anion channel positive modulator
- Acamprosate calcium GABA-A receptor; anion channel positive modulator
- Adipiplon GABA-A receptor; anion channel partial agonist
- Alprazolam GABA-A receptor; anion channel positive allosteric modulator
- Brexanolone GABA-A receptor; anion channel positive allosteric modulator
- Butabarbital GABA-A receptor; anion channel positive allosteric modulator
- Butabarbital sodium GABA-A receptor; anion channel positive allosteric modulator
- Butalbital GABA-A receptor; anion channel positive allosteric modulator
- Cenobamate GABA-A receptor; anion channel positive allosteric modulator
- Chlordiazepoxide GABA-A receptor; anion channel positive allosteric modulator
- Chlordiazepoxide hydrochloride GABA-A receptor; anion channel positive allosteric modulator
- Cipepofol GABA-A receptor; anion channel agonist
- Clobazam GABA-A receptor; anion channel positive allosteric modulator
- Clomethiazole GABA-A receptor; anion channel positive allosteric modulator
- Clonazepam GABA-A receptor; anion channel positive allosteric modulator
- Clorazepate dipotassium GABA-A receptor; anion channel positive allosteric modulator
- Clorazepic acid GABA-A receptor; anion channel positive allosteric modulator
- Clotiazepam GABA-A receptor; anion channel positive allosteric modulator
- Darigabat GABA-A receptor; anion channel agonist