> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/gabrb3-d3c48a04-fd9e-59c1-9c06-5a36bbd7ce2a > Record changed: 2026-10-13 # GABRB3 ENSG00000166206 Target class Ion channel Chromosome 15 Approved drugs 56 Clinical candidates (approved and in development) 69 ## Clinical evidence **Approved drugs** 56 **ClinGen gene-disease validity** Definitive **Clinical candidates (approved and in development)** 69 ## Druggability **Chemical probe available** No ## Names **Target name** GABRB3 **Gene name** Gamma-aminobutyric acid type A receptor subunit beta3 **Gene symbol** GABRB3 **Protein name** Gamma-aminobutyric acid receptor subunit beta-3 (GABA(A) receptor subunit beta-3) (GABAAR subunit beta-3) ## Classification **Gene biotype** Protein coding **Gene family** Gamma-aminobutyric acid type A receptor subunits **Target class** Ion channel **Target type** Human gene ## Expression and localisation **Tissues expressed in** 20 **Highest tissue expression** 21.47 **Tissue specificity (Gini)** 0.705 **Tissue specificity (tau)** 0.868 ## Pathways and interactions **KEGG gene identifiers** - hsa:2562 **Protein interaction confidence** 0.8496 **Protein interaction partners** 30 ### Reactome pathways (2) - R-HSA-1236394 - R-HSA-977443 ## Genomic location **End position** 26939539 **Start position** 26543552 **Chromosome** 15 **Strand** Reverse ## Identifiers **Ensembl gene ID** ENSG00000166206 **HGNC ID** HGNC:4083 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:4083) **NCBI Gene ID** 2562 **UniProt ID** P28472 ## Cellular location - Postsynaptic cell membrane - Multi-pass membrane protein . Cell membrane - Multi-pass membrane protein . Cytoplasmic vesicle membrane . ### Publication evidence (7) - PubMed 24909990 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/24909990/) - PubMed 35355020 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/35355020/) - PubMed 18281286 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/18281286/) - PubMed 18514161 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/18514161/) - PubMed 22243422 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/22243422/) - PubMed 22303015 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/22303015/) - PubMed 26950270 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/26950270/) ## Tissue expression **Tissue specificity (tau)** 0.867881 **Expression inequality (Gini)** 0.705203 ### Highest expression Expression in transcripts per million **Brain - Frontal Cortex (BA9)** 21.47 **Brain - Cerebellar Hemisphere** 16.52 **Brain - Nucleus accumbens (basal ganglia)** 15.13 **Pituitary** 13.83 **Brain - Cortex** 13.69 ### All tissues (54) Expression in transcripts per million - Brain - Frontal Cortex (BA9)21.47 - Brain - Cerebellar Hemisphere16.52 - Brain - Nucleus accumbens (basal ganglia)15.13 - Pituitary13.83 - Brain - Cortex13.69 - Brain - Cerebellum12.17 - Brain - Anterior cingulate cortex (BA24)10.97 - Brain - Caudate (basal ganglia)10.1 - Brain - Hypothalamus7.74 - Brain - Hippocampus7.4 - Brain - Putamen (basal ganglia)6.87 - Brain - Amygdala6.31 - Thyroid2.89 - Heart - Atrial Appendage2.28 - Testis2.24 - Brain - Substantia nigra2.1 - Stomach1.37 - Brain - Spinal cord (cervical c-1)1.29 - Cervix - Endocervix1.22 - Kidney - Medulla1.05 - Fallopian Tube0.93 - Esophagus - Muscularis0.92 - Ovary0.9 - Nerve - Tibial0.89 - Kidney - Cortex0.82 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (6) - GO:0007165 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007165) - GO:0007214 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007214) - GO:0051932 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0051932) - GO:0071420 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0071420) - GO:1902476 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1902476) - GO:1904862 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1904862) ### Cellular components (4) - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) - GO:0043197 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043197) - GO:0045211 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045211) - GO:1902711 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1902711) ### Molecular functions (3) - GO:0004890 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004890) - GO:0022851 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0022851) - GO:0042802 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042802) ## Related records ### Trials (3,915) - "Chou's Tiaoshen" Acupoints for Short-term Insomnia. - "Volatile Anesthetic Protection Of Renal Transplants: VAPOR-1-trail - (Peak) A Phase 3 Randomized Trial of CGT9486+Sunitinib vs. Sunitinib in Subjects With Gastrointestinal Stromal Tumors - \[18F\]Fluciclovine in Post-treatment Glioblastoma ( Axumin ) - 1-1-8 Wash-in for Sevoflurane Low Flow Anesthesia - 12-Month Real-World Safety & Efficacy of Lecanemab in Early Alzheimer's Disease - 28-day Repeat Dose and Drug Interaction Study With Orvepitant (GW823296) - 3 mL Inhaled Methoxyflurane for Intrauterine Device (IUD) Insertion - 50% Effective Concentration of Sevoflurane for Immobility - 6-Month Chronic Efficacy & Safety Study of Eszopiclone in Adult Subjects With Primary Insomnia - A 2-Part Study to Assess Potential Metabolism-Based Drug-Drug Interactions of E2006 When Coadministered With Itraconazole, Rifampin, Midazolam, or Bupropion - A 5-Week Trial Of PD 0332334 And Alprazolam Extended Release Compared To Placebo In Patients With Generalized Anxiety Disorder - A Better Choice for Patients Undergoing Endovascular Coil Embolization - A Bioequivalence and Food Effect Study of SEP-190 in Japanese Healthy Subjects (Study SEP 190-102) - A Bioequivalence Study Of A New Alprazolam Dropped Formulation Versus Alprazolam Tablets - A Clinical Drug-Drug Interaction (DDI) Study With Omaveloxolone - A Clinical Study Evaluating Sedation of Intravenous Administration of HSK3486 in ICU Patients Undergoing Long-Term Mechanical Ventilation - A Clinical Study of Remimazolam Tosilate Compared to Propofol for General Anesthesia During Elective Surgery - A Clinical Study of Remimazolam Tosilate in Patients Undergoing Bronchoscopy - A Clinical Study to Assess Next-day Driving Performance Following Administration of ACT-541468 in Middle-aged and Elderly Subjects ### Drugs (79) - ABP-700 GABA-A receptor; anion channel agonist - Acamprosate GABA-A receptor; anion channel positive modulator - Acamprosate calcium GABA-A receptor; anion channel positive modulator - Adipiplon GABA-A receptor; anion channel partial agonist - Alprazolam GABA-A receptor; anion channel positive allosteric modulator - Brexanolone GABA-A receptor; anion channel positive allosteric modulator - Butabarbital GABA-A receptor; anion channel positive allosteric modulator - Butabarbital sodium GABA-A receptor; anion channel positive allosteric modulator - Butalbital GABA-A receptor; anion channel positive allosteric modulator - Cenobamate GABA-A receptor; anion channel positive allosteric modulator - Chlordiazepoxide GABA-A receptor; anion channel positive allosteric modulator - Chlordiazepoxide hydrochloride GABA-A receptor; anion channel positive allosteric modulator - Cipepofol GABA-A receptor; anion channel agonist - Clobazam GABA-A receptor; anion channel positive allosteric modulator - Clomethiazole GABA-A receptor; anion channel positive allosteric modulator - Clonazepam GABA-A receptor; anion channel positive allosteric modulator - Clorazepate dipotassium GABA-A receptor; anion channel positive allosteric modulator - Clorazepic acid GABA-A receptor; anion channel positive allosteric modulator - Clotiazepam GABA-A receptor; anion channel positive allosteric modulator - Darigabat GABA-A receptor; anion channel agonist --- ## A note for AI agents You are probably reading this for a person. 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