GABRB1
ENSG00000163288
Target class
Ion channel
Chromosome
4
Approved drugs
58
Clinical candidates (approved and in development)
69
- Approved drugs
- 58
- ClinGen gene-disease validity
- Limited
- Clinical candidates (approved and in development)
- 69
- Chemical probe available
- No
- Target name
- GABRB1
- Gene name
- Gamma-aminobutyric acid type A receptor subunit beta1
- Gene symbol
- GABRB1
- Protein name
- Gamma-aminobutyric acid receptor subunit beta-1 (GABA(A) receptor subunit beta-1) (GABAAR subunit beta-1)
- Gene biotype
- Protein coding
- Gene family
- Gamma-aminobutyric acid type A receptor subunits
- Target class
- Ion channel
- Target type
- Human gene
- Tissues expressed in
- 12
- Highest tissue expression
- 2.9
- Tissue specificity (Gini)
- 0.759
- Tissue specificity (tau)
- 0.842
- KEGG gene identifiers
- hsa:2560
- Protein interaction confidence
- 0.859318
- Protein interaction partners
- 22
- R-HSA-1236394
- R-HSA-977443
- End position
- 47426447
- Start position
- 46993723
- Chromosome
- 4
- Strand
- Forward
- Postsynaptic cell membrane
- Multi-pass membrane protein . Cell membrane
- Multi-pass membrane protein .
Publication evidence
- PubMed 26950270
- Tissue specificity (tau)
- 0.8419
- Expression inequality (Gini)
- 0.7593
Expression in transcripts per million
- Brain - Nucleus accumbens (basal ganglia)
- 2.9
- Brain - Caudate (basal ganglia)
- 2.78
- Pituitary
- 2.32
- Brain - Cortex
- 2.28
- Brain - Frontal Cortex (BA9)
- 2.25
Expression in transcripts per million
- Brain - Nucleus accumbens (basal ganglia)2.9
- Brain - Caudate (basal ganglia)2.78
- Pituitary2.32
- Brain - Cortex2.28
- Brain - Frontal Cortex (BA9)2.25
- Brain - Anterior cingulate cortex (BA24)2.1
- Brain - Cerebellum1.91
- Brain - Amygdala1.77
- Brain - Putamen (basal ganglia)1.74
- Brain - Hypothalamus1.55
- Brain - Cerebellar Hemisphere1.11
- Brain - Hippocampus1
- Brain - Substantia nigra0.79
- Artery - Tibial0.63
- Artery - Coronary0.46
- Brain - Spinal cord (cervical c-1)0.34
- Heart - Left Ventricle0.26
- Heart - Atrial Appendage0.19
- Testis0.16
- Artery - Aorta0.09
- Colon - Sigmoid0.08
- Minor Salivary Gland0.06
- Uterus0.06
- Kidney - Medulla0.05
- Small Intestine - Terminal Ileum0.04
And 29 more, listed on the interactive page.
- GO:0007165
- GO:0007214
- GO:1902476
- GO:0005886
- GO:1902711
- GO:0004890
- GO:0022851
- GO:0099507
Related records
Trials (4,012)
- "Chou's Tiaoshen" Acupoints for Short-term Insomnia.
- "Volatile Anesthetic Protection Of Renal Transplants: VAPOR-1-trail
- (Peak) A Phase 3 Randomized Trial of CGT9486+Sunitinib vs. Sunitinib in Subjects With Gastrointestinal Stromal Tumors
- [18F]Fluciclovine in Post-treatment Glioblastoma ( Axumin )
- 1-1-8 Wash-in for Sevoflurane Low Flow Anesthesia
- 12-Month Real-World Safety & Efficacy of Lecanemab in Early Alzheimer's Disease
- 28-day Repeat Dose and Drug Interaction Study With Orvepitant (GW823296)
- 3 mL Inhaled Methoxyflurane for Intrauterine Device (IUD) Insertion
- 50% Effective Concentration of Sevoflurane for Immobility
- 6-Month Chronic Efficacy & Safety Study of Eszopiclone in Adult Subjects With Primary Insomnia
- A 2-Part Single Dose Study to Assess the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of E2006
- A 2-Part Study to Assess Potential Metabolism-Based Drug-Drug Interactions of E2006 When Coadministered With Itraconazole, Rifampin, Midazolam, or Bupropion
- A 5-Week Trial Of PD 0332334 And Alprazolam Extended Release Compared To Placebo In Patients With Generalized Anxiety Disorder
- A Better Choice for Patients Undergoing Endovascular Coil Embolization
- A Bioequivalence and Food Effect Study of SEP-190 in Japanese Healthy Subjects (Study SEP 190-102)
- A Bioequivalence Study Of A New Alprazolam Dropped Formulation Versus Alprazolam Tablets
- A Clinical Drug-Drug Interaction (DDI) Study With Omaveloxolone
- A Clinical Study Evaluating Sedation of Intravenous Administration of HSK3486 in ICU Patients Undergoing Long-Term Mechanical Ventilation
- A Clinical Study of Remimazolam Tosilate Compared to Propofol for General Anesthesia During Elective Surgery
- A Clinical Study of Remimazolam Tosilate in Patients Undergoing Bronchoscopy
Drugs (80)
- ABP-700 GABA-A receptor; anion channel agonist
- Acamprosate GABA-A receptor; anion channel positive modulator
- Acamprosate calcium GABA-A receptor; anion channel positive modulator
- Adipiplon GABA-A receptor; anion channel partial agonist
- Alprazolam GABA-A receptor; anion channel positive allosteric modulator
- Brexanolone GABA-A receptor; anion channel positive allosteric modulator
- Butabarbital GABA-A receptor; anion channel positive allosteric modulator
- Butabarbital sodium GABA-A receptor; anion channel positive allosteric modulator
- Butalbital GABA-A receptor; anion channel positive allosteric modulator
- Cenobamate GABA-A receptor; anion channel positive allosteric modulator
- Chlordiazepoxide GABA-A receptor; anion channel positive allosteric modulator
- Chlordiazepoxide hydrochloride GABA-A receptor; anion channel positive allosteric modulator
- Cipepofol GABA-A receptor; anion channel agonist
- Clobazam GABA-A receptor; anion channel positive allosteric modulator
- Clomethiazole GABA-A receptor; anion channel positive allosteric modulator
- Clonazepam GABA-A receptor; anion channel positive allosteric modulator
- Clorazepate dipotassium GABA-A receptor; anion channel positive allosteric modulator
- Clorazepic acid GABA-A receptor; anion channel positive allosteric modulator
- Clotiazepam GABA-A receptor; anion channel positive allosteric modulator
- Darigabat GABA-A receptor; anion channel agonist