> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/gabra4-8db035f5-598b-561c-bccf-339883590a0d > Record changed: 2026-10-13 # GABRA4 ENSG00000109158 Target class Ion channel Chromosome 4 Approved drugs 56 Clinical candidates (approved and in development) 68 ## Clinical evidence **Approved drugs** 56 **Clinical candidates (approved and in development)** 68 ## Druggability **Chemical probe available** No ## Names **Target name** GABRA4 **Gene name** Gamma-aminobutyric acid type A receptor subunit alpha4 **Gene symbol** GABRA4 **Protein name** Gamma-aminobutyric acid receptor subunit alpha-4 (GABA(A) receptor subunit alpha-4) (GABAAR subunit alpha-4) ## Classification **Gene biotype** Protein coding **Gene family** Gamma-aminobutyric acid type A receptor subunits **Target class** Ion channel **Target type** Human gene ## Expression and localisation **Tissues expressed in** 14 **Highest tissue expression** 10.72 **Tissue specificity (Gini)** 0.815 **Tissue specificity (tau)** 0.917 ## Pathways and interactions **KEGG gene identifiers** - hsa:2557 **Reactome pathways** - R-HSA-977443 **Protein interaction confidence** 0.844294 **Protein interaction partners** 17 ## Genomic location **End position** 46993581 **Start position** 46918900 **Chromosome** 4 **Strand** Reverse ## Identifiers **Ensembl gene ID** ENSG00000109158 **HGNC ID** HGNC:4078 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:4078) **NCBI Gene ID** 2557 **UniProt ID** P48169 ## Cellular location - Cell membrane - Multi-pass membrane protein . Postsynaptic cell membrane - Multi-pass membrane protein . ### Publication evidence - PubMed 35355020 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/35355020/) ## Tissue expression **Tissue specificity (tau)** 0.917312 **Expression inequality (Gini)** 0.814731 ### Highest expression Expression in transcripts per million **Brain - Nucleus accumbens (basal ganglia)** 10.72 **Brain - Caudate (basal ganglia)** 7.97 **Brain - Frontal Cortex (BA9)** 7.74 **Brain - Cortex** 5.11 **Brain - Putamen (basal ganglia)** 4.84 ### All tissues (54) Expression in transcripts per million - Brain - Nucleus accumbens (basal ganglia)10.72 - Brain - Caudate (basal ganglia)7.97 - Brain - Frontal Cortex (BA9)7.74 - Brain - Cortex5.11 - Brain - Putamen (basal ganglia)4.84 - Brain - Anterior cingulate cortex (BA24)4.52 - Brain - Amygdala2.65 - Artery - Tibial1.88 - Artery - Coronary1.81 - Brain - Hypothalamus1.77 - Brain - Hippocampus1.71 - Pituitary1.6 - Brain - Cerebellum1.38 - Heart - Left Ventricle1.29 - Brain - Cerebellar Hemisphere0.68 - Brain - Substantia nigra0.58 - Testis0.2 - Skin - Not Sun Exposed (Suprapubic)0.14 - Artery - Aorta0.14 - Brain - Spinal cord (cervical c-1)0.12 - Small Intestine - Terminal Ileum0.12 - Esophagus - Mucosa0.1 - Skin - Sun Exposed (Lower leg)0.08 - Adipose - Subcutaneous0.08 - Colon - Sigmoid0.06 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (2) - GO:0007214 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007214) - GO:1902476 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1902476) ### Cellular components - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) ### Molecular functions - GO:0008503 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008503) ## On-target safety - decreased cardiac contractility ### Effects - Activation/Increase/Upregulation: acute ### Studies - preclinical: decreased cardiac contractility ### Biological samples (2) - central nervous system - cardiovascular PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - drug abuse/dependence ### Effects - Activation/Increase/Upregulation: acute ### Studies - preclinical: drug abuse/dependence ### Biological samples (2) - central nervous system - cardiovascular PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - decreased memory ### Effects - Activation/Increase/Upregulation: acute ### Studies - preclinical: decreased memory ### Biological samples (2) - central nervous system - cardiovascular PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - decreased sleep ### Effects - Inhibition/Decrease/Downregulation: acute ### Studies - preclinical: decreased sleep ### Biological samples (2) - central nervous system - cardiovascular PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - decreased convulsions ### Effects - Activation/Increase/Upregulation: acute ### Studies - preclinical: decreased convulsions ### Biological samples (2) - central nervous system - cardiovascular PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - decreased locomotor activity ### Effects - Activation/Increase/Upregulation: acute ### Studies - preclinical: decreased locomotor activity ### Biological samples (2) - central nervous system - cardiovascular PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - increased eating ### Effects - Activation/Increase/Upregulation: acute ### Studies - preclinical: increased eating ### Biological samples (2) - central nervous system - cardiovascular PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - decreased blood pressure ### Effects - Activation/Increase/Upregulation: acute ### Studies - preclinical: decreased blood pressure ### Biological samples (2) - central nervous system - cardiovascular PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - muscle relaxation ### Effects - Activation/Increase/Upregulation: acute ### Studies - preclinical: muscle relaxation ### Biological samples (2) - central nervous system - cardiovascular PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - decreased body temperature ### Effects - Activation/Increase/Upregulation: acute ### Studies - preclinical: decreased body temperature ### Biological samples (2) - central nervous system - cardiovascular PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - decreased pain ### Effects - Activation/Increase/Upregulation: acute ### Studies - preclinical: decreased pain ### Biological samples (2) - central nervous system - cardiovascular PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - convulsions ### Effects - Inhibition/Decrease/Downregulation: acute ### Studies - preclinical: convulsions ### Biological samples (2) - central nervous system - cardiovascular PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - decreased anxiety ### Effects - Activation/Increase/Upregulation: acute ### Studies - preclinical: decreased anxiety ### Biological samples (2) - central nervous system - cardiovascular PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - increased respiratory rate ### Effects - Activation/Increase/Upregulation: acute ### Studies - preclinical: increased respiratory rate ### Biological samples (2) - central nervous system - cardiovascular PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - ataxia ### Effects - Activation/Increase/Upregulation: acute ### Studies - preclinical: ataxia ### Biological samples (2) - central nervous system - cardiovascular PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - increased cardiac output ### Effects - Activation/Increase/Upregulation: acute ### Studies - preclinical: increased cardiac output ### Biological samples (2) - central nervous system - cardiovascular PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - increased sleep ### Effects - Activation/Increase/Upregulation: acute ### Studies - preclinical: increased sleep ### Biological samples (2) - central nervous system - cardiovascular PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) ## Related records ### Trials (3,914) - "Chou's Tiaoshen" Acupoints for Short-term Insomnia. - "Volatile Anesthetic Protection Of Renal Transplants: VAPOR-1-trail - (Peak) A Phase 3 Randomized Trial of CGT9486+Sunitinib vs. Sunitinib in Subjects With Gastrointestinal Stromal Tumors - \[18F\]Fluciclovine in Post-treatment Glioblastoma ( Axumin ) - 1-1-8 Wash-in for Sevoflurane Low Flow Anesthesia - 12-Month Real-World Safety & Efficacy of Lecanemab in Early Alzheimer's Disease - 28-day Repeat Dose and Drug Interaction Study With Orvepitant (GW823296) - 3 mL Inhaled Methoxyflurane for Intrauterine Device (IUD) Insertion - 50% Effective Concentration of Sevoflurane for Immobility - 6-Month Chronic Efficacy & Safety Study of Eszopiclone in Adult Subjects With Primary Insomnia - A 2-Part Study to Assess Potential Metabolism-Based Drug-Drug Interactions of E2006 When Coadministered With Itraconazole, Rifampin, Midazolam, or Bupropion - A 5-Week Trial Of PD 0332334 And Alprazolam Extended Release Compared To Placebo In Patients With Generalized Anxiety Disorder - A Better Choice for Patients Undergoing Endovascular Coil Embolization - A Bioequivalence and Food Effect Study of SEP-190 in Japanese Healthy Subjects (Study SEP 190-102) - A Bioequivalence Study Of A New Alprazolam Dropped Formulation Versus Alprazolam Tablets - A Clinical Drug-Drug Interaction (DDI) Study With Omaveloxolone - A Clinical Study Evaluating Sedation of Intravenous Administration of HSK3486 in ICU Patients Undergoing Long-Term Mechanical Ventilation - A Clinical Study of Remimazolam Tosilate Compared to Propofol for General Anesthesia During Elective Surgery - A Clinical Study of Remimazolam Tosilate in Patients Undergoing Bronchoscopy - A Clinical Study to Assess Next-day Driving Performance Following Administration of ACT-541468 in Middle-aged and Elderly Subjects ### Drugs (78) - ABP-700 GABA-A receptor; anion channel agonist - Acamprosate GABA-A receptor; anion channel positive modulator - Acamprosate calcium GABA-A receptor; anion channel positive modulator - Adipiplon GABA-A receptor; anion channel partial agonist - Alprazolam GABA-A receptor; anion channel positive allosteric modulator - Brexanolone GABA-A receptor; anion channel positive allosteric modulator - Butabarbital GABA-A receptor; anion channel positive allosteric modulator - Butabarbital sodium GABA-A receptor; anion channel positive allosteric modulator - Butalbital GABA-A receptor; anion channel positive allosteric modulator - Cenobamate GABA-A receptor; anion channel positive allosteric modulator - Chlordiazepoxide GABA-A receptor; anion channel positive allosteric modulator - Chlordiazepoxide hydrochloride GABA-A receptor; anion channel positive allosteric modulator - Cipepofol GABA-A receptor; anion channel agonist - Clobazam GABA-A receptor; anion channel positive allosteric modulator - Clomethiazole GABA-A receptor; anion channel positive allosteric modulator - Clonazepam GABA-A receptor; anion channel positive allosteric modulator - Clorazepate dipotassium GABA-A receptor; anion channel positive allosteric modulator - Clorazepic acid GABA-A receptor; anion channel positive allosteric modulator - Clotiazepam GABA-A receptor; anion channel positive allosteric modulator - Darigabat GABA-A receptor; anion channel agonist --- ## A note for AI agents You are probably reading this for a person. 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