> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/fyn-f4b118d5-c9e0-5a7e-89a5-603739fec8b8 > Record changed: 2026-11-04 # FYN ENSG00000010810 Target class Kinase Chromosome 6 Approved drugs 1 Clinical candidates (approved and in development) 6 ## Clinical evidence **Approved drugs** 1 **Clinical candidates (approved and in development)** 6 ## Druggability **Chemical probe available** Yes ## Names **Target name** FYN **Gene name** FYN proto-oncogene, Src family tyrosine kinase **Gene symbol** FYN **Protein name** Tyrosine-protein kinase Fyn (EC 2.7.10.2) (Proto-oncogene Syn) (Proto-oncogene c-Fyn) (Src-like kinase) (SLK) (p59-Fyn) ### Other names (3) - SYN - SLK - MGC45350 ## Classification **Gene biotype** Protein coding **Gene family** SH2 domain containing|Src family tyrosine kinases **Target class** Kinase **Target type** Human gene ## Expression and localisation **Tissues expressed in** 54 **Protein localisation evidence grade** Supported **Highest tissue expression** 71.31 **Tissue specificity (Gini)** 0.319 **Tissue specificity (tau)** 0.558 ## Pathways and interactions **KEGG gene identifiers** - hsa:2534 **Protein interaction confidence** 0.875526 **Protein interaction partners** 171 ### Reactome pathways (41) - R-HSA-114604 - R-HSA-1227986 - R-HSA-1257604 - R-HSA-1433557 - R-HSA-1433559 - R-HSA-164944 - R-HSA-202733 - R-HSA-2029481 - R-HSA-210990 - R-HSA-2219530 - R-HSA-2424491 - R-HSA-2682334 - R-HSA-2730905 - R-HSA-373753 - R-HSA-375165 - R-HSA-389356 - R-HSA-389357 - R-HSA-389359 - R-HSA-389513 - R-HSA-3928662 - R-HSA-3928663 - R-HSA-3928664 - R-HSA-3928665 - R-HSA-399954 - R-HSA-399955 And 16 more, listed on the interactive page. ## Genomic location **End position** 111873475 **Start position** 111660332 **Chromosome** 6 **Strand** Reverse ## Identifiers **Ensembl gene ID** ENSG00000010810 **HGNC ID** HGNC:4037 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:4037) **NCBI Gene ID** 2534 **UniProt ID** P06241 ## Cellular location - Cytoplasm . Nucleus . Cell membrane . Perikaryon . Note=Present and active in lipid rafts (PubMed:12218089). Palmitoylation is crucial for proper trafficking (PubMed:8206991). . - Cytosol - Plasma membrane ### Publication evidence (3) - PubMed 15537652 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/15537652/) - PubMed 8206991 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/8206991/) - PubMed 12218089 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/12218089/) ## Tissue expression **Tissue specificity (tau)** 0.557589 **Expression inequality (Gini)** 0.319122 ### Highest expression Expression in transcripts per million **Nerve - Tibial** 71.31 **Adipose - Subcutaneous** 64.23 **Brain - Cerebellar Hemisphere** 58.85 **Lung** 58.09 **Brain - Cerebellum** 55.83 ### All tissues (54) Expression in transcripts per million - Nerve - Tibial71.31 - Adipose - Subcutaneous64.23 - Brain - Cerebellar Hemisphere58.85 - Lung58.09 - Brain - Cerebellum55.83 - Spleen52.82 - Adipose - Visceral (Omentum)52.51 - Brain - Frontal Cortex (BA9)51.37 - Cells - Cultured fibroblasts50.84 - Cervix - Endocervix50.78 - Brain - Amygdala50.72 - Uterus50.05 - Cervix - Ectocervix49.61 - Brain - Cortex49.55 - Brain - Anterior cingulate cortex (BA24)47.18 - Brain - Spinal cord (cervical c-1)46.7 - Brain - Nucleus accumbens (basal ganglia)45.36 - Brain - Hypothalamus43.5 - Fallopian Tube42.87 - Brain - Caudate (basal ganglia)42.25 - Brain - Hippocampus41.71 - Thyroid39.91 - Brain - Substantia nigra39.9 - Bladder38.8 - Brain - Putamen (basal ganglia)36.98 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (20) - GO:0002223 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0002223) - GO:0002862 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0002862) - GO:0003015 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0003015) - GO:0007216 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007216) - GO:0007411 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007411) - GO:0007612 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007612) - GO:0007631 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007631) - GO:0030101 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030101) - GO:0031295 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0031295) - GO:0035556 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0035556) - GO:0038096 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0038096) - GO:0048010 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0048010) - GO:0048013 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0048013) - GO:0050852 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0050852) - GO:0050860 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0050860) - GO:0050868 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0050868) - GO:0050900 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0050900) - GO:0097062 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0097062) - GO:1904646 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1904646) - GO:1905477 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1905477) ### Cellular components (7) - GO:0005634 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005634) - GO:0005737 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005737) - GO:0005768 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005768) - GO:0005829 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005829) - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) - GO:0030425 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030425) - GO:0045121 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045121) ### Molecular functions (13) - GO:0001664 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0001664) - GO:0004713 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004713) - GO:0004715 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004715) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0016004 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016004) - GO:0019899 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0019899) - GO:0042802 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042802) - GO:0043274 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043274) - GO:0046875 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0046875) - GO:0048156 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0048156) - GO:0070851 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070851) - GO:0097110 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0097110) - GO:0097718 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0097718) ## Off-target safety - regulation of catalytic activity ### Studies (2) - biochemical: NVS\_ENZ\_hFyn, is one of one assay component(s) measured or calculated from the NVS\_ENZ\_hFyn assay. It is designed to make measurements of enzyme activity, a form of enzyme reporter, as detected with fluorescence intensity signals by Fluorescence and electrophoretic mobility shift technology. - biochemical: NVS\_ENZ\_hFyn, is one of one assay component(s) measured or calculated from the NVS\_ENZ\_hFyn assay. It is designed to make measurements of enzyme activity, a form of enzyme reporter, as detected with fluorescence intensity signals by Fluorescence and electrophoretic mobility shift technology. ### Biological samples - cell-free Evidence source Source: [www.epa.gov](https://www.epa.gov/chemical-research/exploring-toxcast-data-downloadable-data) ## Related records ### Trials (892) - A Bioequivalence Study of Dasatinib Tablet - A Clinical Trial Evaluating the Efficacy and Safety of Dasatinib in Refractory Metastatic GIST - A Clinical Trial of Buparlisib and Ibrutinib in Lymphoma - A Combination of Acalabrutinib With R-CHOP for Patient Diffuse Large B-cell Lymphoma (DLBCL) - A Combination of Acalabrutinib With R-CHOP in Subjects With Previously Untreated Non-GCB DLBCL (ACE-LY-312) - A Comparison of Three Chemotherapy Regimens for the Treatment of Patients With Newly Diagnosed Mantle Cell Lymphoma - A Crossover Study to Evaluate the Bioavailability of Ibrutinib Suspension and Sprinkle Formulations Compared to Capsules in Healthy Adults - A Dose Escalation and Expansion Study Evaluating the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of RO7283420. - A Drug Interaction Study Between Bosutinib And Aprepitant In Healthy Volunteers - A Drug Interaction Study to Assess the Effect of Omeprazole on the Pharmacokinetics of Ibrutinib in Healthy Adults - A Long-term Extension Study of PCI-32765 (Ibrutinib) - A Multi-Center Study of Ibrutinib in Combination With MEDI4736 in Subjects With Relapsed or Refractory Lymphomas - A Multi-Center Study of Ibrutinib in Combination With MEDI4736 in Subjects With Relapsed or Refractory Solid Tumors - A Multi-Center Study of Ibrutinib in Combination With Obinutuzumab Versus Chlorambucil in Combination With Obinutuzumab in Patients With Treatment naïve Chronic Lymphocytic Leukemia (CLL) or Small Lymphocytic Lymphoma (SLL) - A Multicenter Phase 2 Study of Ibrutinib in Patients With Relapsed or Refractory Chronic Lymphocytic Leukemia (CLL) or Small Lymphocytic Lymphoma (SLL) With 17p Deletion - A Multicenter Phase 3, Open-Label Study of Bosutinib Versus Imatinib in Adult Patients With Newly Diagnosed Chronic Phase Chronic Myelogenous Leukemia - A Pharmacokinetic Study in Healthy Participants to Assess the Pharmacokinetics and Safety of a Supratherapeutic Dose of PCI-32765 (Ibrutinib) Capsule and Solution Formulations Administered With Food - A Phase 1 Safety Study of TG100801 Eye Drops in Healthy Volunteers - A Phase 1 Study of Acalabrutinib in Japanese Adult Patients With Advanced B-cell Malignancies - A Phase 1 Study of MKC-1 in Patients With Refractory Hematologic Malignancies ### Drugs (12) - [Acalabrutinib](https://trialight.com/data/asset/acalabrutinib-17f298f9-e056-45ab-95dc-9a5b0f25c869.md) - Bosutinib - Dasatinib - Dasatinib anhydrous SRC inhibitor - Dasatinib laurylsulfate SRC inhibitor - ENMD-981693 SRC inhibitor - [Ibrutinib](https://trialight.com/data/asset/ibrutinib-0b3ac4fd-6e98-4847-a711-2f599e8bb93d.md) - Ilorasertib SRC inhibitor - JNJ-26483327 Tyrosine-protein kinase FYN inhibitor - Pexmetinib - TG100-801 SRC inhibitor - XL-228 SRC inhibitor --- ## A note for AI agents You are probably reading this for a person. 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