> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/target/frk-ab68d7fb-f5b8-5215-b28b-81b0e05a4401
> Record changed: 2026-10-13

# FRK

ENSG00000111816

Target class

Kinase

Chromosome

6

Approved drugs

2

Clinical candidates (approved and in development)

6

## Clinical evidence

**Approved drugs**

2

**Clinical candidates (approved and in development)**

6

## Druggability

**Chemical probe available**

No

## Names

**Target name**

FRK

**Gene name**

Fyn related Src family tyrosine kinase

**Gene symbol**

FRK

**Previous gene symbols**

- PTK5

**Protein name**

Tyrosine-protein kinase FRK (EC 2.7.10.2) (FYN-related kinase) (Nuclear tyrosine protein kinase RAK) (Protein-tyrosine kinase 5)

### Other names (2)

- RAK
- GTK

## Classification

**Gene biotype**

Protein coding

**Gene family**

SH2 domain containing|Src family tyrosine kinases

**Target class**

Kinase

**Target type**

Human gene

## Expression and localisation

**Tissues expressed in**

28

**Protein localisation evidence grade**

Supported

**Highest tissue expression**

8.67

**Tissue specificity (Gini)**

0.544

**Tissue specificity (tau)**

0.817

## Pathways and interactions

**KEGG gene identifiers**

- hsa:2444

**Protein interaction confidence**

0.896333

**Protein interaction partners**

6

### Reactome pathways (2)

- R-HSA-6798695
- R-HSA-8948751

## Genomic location

**End position**

116061093

**Start position**

115931149

**Chromosome**

6

**Strand**

Reverse

## Identifiers

**Ensembl gene ID**

ENSG00000111816

**HGNC ID**

HGNC:3955

Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:3955)

**NCBI Gene ID**

2444

**UniProt ID**

P42685

## Cellular location

- Cytoplasm . Nucleus . Note=Predominantly found in the nucleus, with a small fraction found in the cell periphery.
- Cytosol
- Nucleoplasm

### Publication evidence

- PubMed 7696183  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/7696183/)

## Tissue expression

**Tissue specificity (tau)**

0.816805

**Expression inequality (Gini)**

0.543958

### Highest expression

Expression in transcripts per million

**Artery - Tibial**

8.67

**Artery - Coronary**

7.54

**Artery - Aorta**

7.33

**Minor Salivary Gland**

4.84

**Esophagus - Mucosa**

4.67

### All tissues (54)

Expression in transcripts per million

- Artery - Tibial8.67
- Artery - Coronary7.54
- Artery - Aorta7.33
- Minor Salivary Gland4.84
- Esophagus - Mucosa4.67
- Kidney - Medulla4.24
- Kidney - Cortex3.98
- Stomach3.79
- Liver3.11
- Small Intestine - Terminal Ileum3.1
- Colon - Transverse2.9
- Cells - EBV-transformed lymphocytes2.82
- Vagina2.16
- Testis2.12
- Lung2.05
- Cervix - Ectocervix2.01
- Prostate1.78
- Pancreas1.73
- Bladder1.6
- Cervix - Endocervix1.47
- Fallopian Tube1.37
- Heart - Left Ventricle1.31
- Adrenal Gland1.31
- Breast - Mammary Tissue1.29
- Brain - Spinal cord (cervical c-1)1.25

And 29 more, listed on the interactive page.

## Biological functions

### Biological processes

- GO:0000122  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0000122)

### Cellular components (8)

- GO:0005576  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005576)
- GO:0005634  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005634)
- GO:0005654  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005654)
- GO:0005737  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005737)
- GO:0005829  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005829)
- GO:0035578  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0035578)
- GO:0035580  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0035580)
- GO:0070062  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070062)

### Molecular functions (3)

- GO:0004713  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004713)
- GO:0004715  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004715)
- GO:0005515  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515)

## Related records

### Trials (407)

- "Thymalfasin Immunotherapy Study with Triple Regimen in Advanced MSS/pMMR Colorectal Cancer"
- (VOYAGER) Study of Avapritinib vs Regorafenib in Patients With Locally Advanced Unresectable or Metastatic GIST
- \[18F\]FLT-PET as a Predictive Imaging Biomaker of Treatment Responses to Regorafenib
- \[18F\]Fluoroestradiol-PET/CT Companion Imaging Study to the FORESEE Trial
- \[18F\]Fluoroestradiol-PET/CT Imaging of Invasive Lobular Carcinoma
- \[68 Ga\]-DOTANOC PET/CT in GEP-NETs
- \[68Ga\]Ga-FAPI-46 in Staging of Head and Neck Carcinomas
- \[68Ga\]Ga-PentixaFor PET/CT in Acute Myocardial Inflammation
- 11C-methionine in Diagnostics and Management of Glioblastoma Multiforme Patients (GlioMET)
- 18F-DCFBC PET/CT in Prostate Cancer
- 18F-DCFPyL Positron Emission Tomography (PET)/Computed Tomography (CT) in Men With Prostate Cancer
- 5-Fluorouracil/Leucovorin (5FU/LV) in Combination With Regorafenib in Patients With Metastatic Colorectal Cancer
- 68Ga-NODAGA-RGD PET/ CT for Tumoral Neoangiogenesis
- 68Ga-NY104 PET/CT Guided Radiation Therapy in CcRCC.
- 68Ga-NYM096/177Lu-NYM096 in Metastatic ccRCC
- 68Ga-PSMA PET/CT in Prostate Cancer
- 68Ga-PSMA PET/CT in Prostate Cancer
- 68Ga-RM2 Compared to 68Ga-PSMA-617 PET/CT for Intermediate Risk Prostate Cancer Imaging
- 68Ga-RM2 Compared to 68Ga-PSMA-617 PET/CT for Prostate Cancer Imaging According to Various Metastatic Risks
- 89Zr-TLX250 for PET/CT Imaging of ccRCC - ZIRCON-CP Study

### Drugs (6)

- Dasatinib anhydrous SRC inhibitor
- ENMD-981693 SRC inhibitor
- Ilorasertib SRC inhibitor
- [Regorafenib](https://trialight.com/data/asset/regorafenib-333c1c36-b89a-41d5-b39e-bcec7346fe94.md) Tyrosine-protein kinase FRK inhibitor
- TG100-801 SRC inhibitor
- XL-228 SRC inhibitor

---

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