> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/target/folr1-3dbc28ad-76ef-5b5b-8224-48316fe90d6f
> Record changed: 2026-10-13

# FOLR1

ENSG00000110195

Target class

Membrane receptor

Chromosome

11

Approved drugs

1

Clinical candidates (approved and in development)

4

## Clinical evidence

**Approved drugs**

1

**ClinGen gene-disease validity**

Definitive

**Clinical candidates (approved and in development)**

4

## Druggability

**Chemical probe available**

Yes

## Names

**Other names**

- FRα

**Target name**

FOLR1

**Gene name**

Folate receptor alpha

**Gene symbol**

FOLR1

**Previous gene symbols**

- FOLR

**Protein name**

Folate receptor alpha (FR-alpha) (Adult folate-binding protein) (FBP) (Folate receptor 1) (Folate receptor, adult) (KB cells FBP) (Ovarian tumor-associated antigen MOv18)

## Classification

**Gene biotype**

Protein coding

**Target class**

Membrane receptor

**Target type**

Human gene

## Expression and localisation

**Tissues expressed in**

17

**Highest tissue expression**

102.8

**Tissue specificity (Gini)**

0.878

**Tissue specificity (tau)**

0.955

## Pathways and interactions

**KEGG gene identifiers**

- hsa:2348

**Protein interaction confidence**

0.757833

**Protein interaction partners**

6

### Reactome pathways (3)

- R-HSA-204005
- R-HSA-5694530
- R-HSA-6807878

## Genomic location

**End position**

72196323

**Start position**

72189558

**Chromosome**

11

**Strand**

Forward

## Identifiers

**Ensembl gene ID**

ENSG00000110195

**HGNC ID**

HGNC:3791

Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:3791)

**NCBI Gene ID**

2348

**UniProt ID**

P15328

## Cellular location

- Cell membrane
- Lipid-anchor, GPI-anchor . Apical cell membrane
- Lipid-anchor, GPI-anchor . Basolateral cell membrane
- Lipid-anchor, GPI-like-anchor . Secreted . Cytoplasmic vesicle . Cytoplasmic vesicle, clathrin-coated vesicle . Endosome . Note=Endocytosed into cytoplasmic vesicles and then recycled to the cell membrane. .

### Publication evidence (7)

- PubMed 2527252  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/2527252/)
- PubMed 8033114  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/8033114/)
- PubMed 8567728  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/8567728/)
- PubMed 17566972  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/17566972/)
- PubMed 7578066  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/7578066/)
- PubMed 10787414  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/10787414/)
- PubMed 3476960  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/3476960/)

## Tissue expression

**Tissue specificity (tau)**

0.954649

**Expression inequality (Gini)**

0.877909

### Highest expression

Expression in transcripts per million

**Lung**

102.8

**Minor Salivary Gland**

72.43

**Kidney - Cortex**

49.4

**Kidney - Medulla**

47.69

**Thyroid**

32.66

### All tissues (54)

Expression in transcripts per million

- Lung102.8
- Minor Salivary Gland72.43
- Kidney - Cortex49.4
- Kidney - Medulla47.69
- Thyroid32.66
- Stomach10.04
- Pituitary6.72
- Fallopian Tube5.55
- Breast - Mammary Tissue2.5
- Skin - Sun Exposed (Lower leg)1.97
- Pancreas1.64
- Brain - Hippocampus1.16
- Skin - Not Sun Exposed (Suprapubic)1.16
- Prostate1.11
- Adrenal Gland1.03
- Brain - Substantia nigra1
- Nerve - Tibial1
- Brain - Hypothalamus0.89
- Brain - Spinal cord (cervical c-1)0.81
- Brain - Caudate (basal ganglia)0.79
- Brain - Nucleus accumbens (basal ganglia)0.77
- Brain - Amygdala0.69
- Cervix - Endocervix0.52
- Brain - Anterior cingulate cortex (BA24)0.49
- Testis0.4

And 29 more, listed on the interactive page.

## Biological functions

### Biological processes (3)

- GO:0006898  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006898)
- GO:0015884  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0015884)
- GO:0071231  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0071231)

### Cellular components (15)

- GO:0000139  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0000139)
- GO:0005634  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005634)
- GO:0005768  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005768)
- GO:0005789  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005789)
- GO:0005886  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886)
- GO:0009897  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0009897)
- GO:0009986  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0009986)
- GO:0012507  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0012507)
- GO:0016020  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016020)
- GO:0016323  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016323)
- GO:0016324  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016324)
- GO:0030133  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030133)
- GO:0031410  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0031410)
- GO:0033116  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0033116)
- GO:0070062  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070062)

### Molecular functions (4)

- GO:0005515  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515)
- GO:0005542  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005542)
- GO:0038023  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0038023)
- GO:0061714  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0061714)

## Related records

### Trials (53)

- A Phase 2 Study of Mirvetuximab Soravtansine (IMGN853) and Pembrolizumab in Endometrial Cancer (EC)
- A Real-world Study of Mirvetuximab Soravtansine (MIRV) in Ovarian Cancer Patients of Expression of Folate Receptor α（FRα）
- A Safety and Efficacy Study of Farletuzumab in Participants With Adenocarcinoma of the Lung
- A Single-arm Clinical Trial of IMGN853 in Chinese Adult Patients With Platinum-resistant, Epithelial Ovarian Cancer
- A Study of Mirvetuximab Soravtansine in Platinum-Resistant, Advanced High-Grade Epithelial Ovarian, Primary Peritoneal, or Fallopian Tube Cancers With High Folate Receptor-Alpha Expression
- A Study of Mirvetuximab Soravtansine vs. Investigator's Choice (IC) of Chemotherapy in Platinum-Resistant, Advanced High-Grade Epithelial Ovarian, Primary Peritoneal, or Fallopian Tube Cancers With High Folate Receptor-Alpha (FRα) Expression
- A Study of Mirvetuximab Soravtansine vs. Investigator's Choice of Chemotherapy in Women With Folate Receptor (FR) Alpha Positive Advanced Epithelial Ovarian Cancer (EOC), Primary Peritoneal or Fallopian Tube Cancer
- A Study of MK-8109 (Vintafolide) Given Alone or With Chemotherapy in Participants With Advanced Cancers (MK-8109-001)
- A Study of MORAb-003 in Patients With Solid Tumor
- A Study of Ocular Toxicity Evaluation and Mitigation During Treatment With Mirvetuximab Soravtansine in Participants With Recurrent Ovarian Cancer With High Folate Receptor-Alpha Expression
- A Study of Vintafolide (MK-8109) in Participants With Advanced Solid Tumor (MK-8109-011)
- A Study to Assess Adverse Events and Change in Disease Activity in Participants With Platinum-Resistant Advanced High-Grade Epithelial Ovarian, Primary Peritoneal, or Fallopian Tube Cancers With High Folate Receptor-Alpha Expression Treated With Intravenously (IV) Infused Mirvetuximab Soravtansine
- [A Study to Assess Adverse Events and Change in Disease Activity of Multiple Treatment Combinations With Intravenous Mirvetuximab Soravtansine in Adult Participants With Ovarian Cancer](https://trialight.com/data/trial/a-study-to-assess-adverse-events-and-change-in-disease-4c2395f0-2637-4f27-b160-827d55d4ed4e.md)
- A Study to Assess Anti-Tumor Activity of Intravenously (IV) Infused Carboplatin With Mirvetuximab Soravtansine in Participants With Newly Diagnosed Folate Receptor Alpha (FRα)Expressing Advanced-Stage Serous Epithelial Ovarian, Fallopian Tube or Primary Peritoneal Cancer.
- A Study to Assess Safety and Immunogenicity of Conserved Mosaic HIV-1 Vaccines
- A Study to Assess the Efficacy and Safety of Farletuzumab (MORAb 003) in Combination With Carboplatin Plus Paclitaxel or Carboplatin Plus Pegylated Liposomal Doxorubicin (PLD) in Participants With Low CA125 Platinum-sensitive Ovarian Cancer
- A Study to Evaluate the Safety, Tolerability, and Immunogenicity of a Modified RNA Vaccine Against Influenza
- [A Three-Part Phase 3 Study of Sofetabart Mipitecan in Participants With Platinum-Resistant (Part A) and Platinum-Sensitive (Parts B and C) Ovarian Cancer](https://trialight.com/data/trial/a-three-part-phase-3-study-of-sofetabart-mipitecan-in-3b115f47-6a88-45c9-8368-039648a15fa4.md)
- An Efficacy and Safety Study of MORAb-003 in Platinum-Resistant or Refractory Relapsed Ovarian Cancer
- An Evaluation of Maintenance Therapy Combination Mirvetuximab Soravtansine and Olaparib

### Drugs (4)

- Farletuzumab Folate receptor alpha inhibitor
- Mirvetuximab Folate receptor alpha binding agent
- [Mirvetuximab soravtansine](https://trialight.com/data/asset/mirvetuximab-soravtansine-a419d018-8e19-417e-8ba5-efe1d263c12b.md) Folate receptor alpha binding agent
- Vintafolide Folate receptor alpha binding agent

---

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