> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/folh1-d75894e5-568c-56e9-a094-d16901b86daf > Record changed: 2026-10-13 # FOLH1 ENSG00000086205 Target class Enzyme Chromosome 11 Approved drugs 1 Clinical candidates (approved and in development) 8 ## Clinical evidence **Approved drugs** 1 **Clinical candidates (approved and in development)** 8 ## Druggability **Chemical probe available** No ## Names **Target name** FOLH1 **Gene name** Folate hydrolase 1 **Gene symbol** FOLH1 **Previous gene symbols** - FOLH **Protein name** Glutamate carboxypeptidase 2 (EC 3.4.17.21) (Cell growth-inhibiting gene 27 protein) (Folate hydrolase 1) (Folylpoly-gamma-glutamate carboxypeptidase) (FGCP) (Glutamate carboxypeptidase II) (GCPII) (Membrane glutamate carboxypeptidase) (mGCP) (N-acetylated-alpha-linked acidic dipeptidase I) (NAALADase I) (Prostate-specific membrane antigen) (PSM) (PSMA) (Pteroylpoly-gamma-glutamate carboxypeptidase) ### Other names (6) - PSM - PSMA - NAALAD1 - NAALAdase - GCP2 - GCPII ## Classification **Gene biotype** Protein coding **Gene family** M28 metallopeptidases **Target class** Enzyme **Target type** Human gene ## Expression and localisation **Tissues expressed in** 27 **Highest tissue expression** 60.73 **Tissue specificity (Gini)** 0.751 **Tissue specificity (tau)** 0.934 ## Pathways and interactions **KEGG gene identifiers** - hsa:2346 **Reactome pathways** - R-HSA-8963693 **Protein interaction confidence** 0.823333 **Protein interaction partners** 21 ## Genomic location **End position** 49208640 **Start position** 49145092 **Chromosome** 11 **Strand** Reverse ## Identifiers **Ensembl gene ID** ENSG00000086205 **HGNC ID** HGNC:3788 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:3788) **NCBI Gene ID** 2346 **UniProt ID** Q04609 ## Cellular location - Cell membrane - Single-pass type II membrane protein . - SUBCELLULAR LOCATION: \[Isoform PSMA'\]: Cytoplasm . ### Publication evidence - PubMed 9809977 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/9809977/) ## Tissue expression **Tissue specificity (tau)** 0.933712 **Expression inequality (Gini)** 0.751272 ### Highest expression Expression in transcripts per million **Brain - Spinal cord (cervical c-1)** 60.73 **Prostate** 50.96 **Brain - Substantia nigra** 21.56 **Brain - Hippocampus** 17.18 **Minor Salivary Gland** 13.9 ### All tissues (54) Expression in transcripts per million - Brain - Spinal cord (cervical c-1)60.73 - Prostate50.96 - Brain - Substantia nigra21.56 - Brain - Hippocampus17.18 - Minor Salivary Gland13.9 - Brain - Putamen (basal ganglia)13.21 - Brain - Amygdala10.94 - Brain - Caudate (basal ganglia)9.82 - Nerve - Tibial9.48 - Brain - Hypothalamus8.67 - Brain - Nucleus accumbens (basal ganglia)5.17 - Liver4.93 - Brain - Frontal Cortex (BA9)4.67 - Brain - Cortex4.67 - Spleen2.68 - Brain - Anterior cingulate cortex (BA24)2.68 - Fallopian Tube2.59 - Brain - Cerebellum2.36 - Kidney - Cortex2.32 - Brain - Cerebellar Hemisphere2.2 - Lung1.9 - Kidney - Medulla1.73 - Breast - Mammary Tissue1.67 - Cervix - Endocervix1.57 - Skin - Sun Exposed (Lower leg)1.34 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (4) - GO:0006508 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006508) - GO:0097054 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0097054) - GO:0098829 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0098829) - GO:1900451 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1900451) ### Cellular components (5) - GO:0005737 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005737) - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) - GO:0009986 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0009986) - GO:0016020 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016020) - GO:0070062 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070062) ### Molecular functions (3) - GO:0004181 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004181) - GO:1904492 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1904492) - GO:1904493 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1904493) ## Related records ### Trials (54) - 177 LuPSMA-617 vs Docetaxel in Metastatic Castration Resistant and PSMA-Positive Prostate Cancer - 177^Lu-PSMA-617 in Combination With Sipuleucel-T for the Treatment of Metastatic Castration-Resistant Prostate Cancer - 177Lu Radiolabeled Monoclonal Antibody HuJ591 (177Lu-J591) and Ketoconazole in Patients With Prostate Cancer - 177Lu-J591 and 177Lu-PSMA-617 Combination for mCRPC - 177Lu-J591 Antibody in Patients With Nonprostate Metastatic Solid Tumors - 177Lu-PSMA as a Systemic Adjuvant Treatment in Patients With High and Very High Risk Prostate Cancer - 177Lu-PSMA-617 in Metastatic Castration Resistant Prostate Cancer (mCRPC) With Bone Marrow Involvement and Cytopenia - 177Lu-PSMA-617 Managed Access Program for mCRPC Patients - 177Lu-PSMA-617 vs. Androgen Receptor-Directed Therapy in the Treatment of Progressive Metastatic Castrate Resistant Prostate Cancer - 177Lu-PSMA-617 With Liver Directed Therapy in Metastatic Castration Resistant Prostate Cancer - 177Lu-PSMA, Niraparib/AA Plus Prednisone for Prostate Cancer - 177LuPSMA in Renal Cell Carcinoma - A Dosimetry Study of Lutetium (177Lu) rhPSMA-10.1 and Lutetium (177Lu) Vipivotide Tetraxetan (Pluvicto®) in Patients With Non-curative Metastatic Prostate Cancer - A Study of 177Lu-PSMA-617 in People With Gliomas - [A Study of JNJ-87189401 Combined With JNJ-78278343 for Advanced Prostate Cancer](https://trialight.com/data/trial/a-study-of-jnj-87189401-combined-with-jnj-78278343-for-88d12617-8532-42f8-a18f-75e3aab31aa8.md) - [A Study of Pasritamig (JNJ-78278343) in Combination With Other Agents for Metastatic Prostate Cancer](https://trialight.com/data/trial/a-study-of-pasritamig-jnj-78278343-in-combination-with-other-e6590381-7e15-4bbc-982a-d0945f86d1f5.md) - A Study of Stereotactic Body Radiotherapy and 177Lu-PSMA-617 for the Treatment of Prostate Cancer - Alpha-Emitting Radionuclide or Beta-Emitting Radionuclide With Metastasis-Directed Stereotactic Body Radiotherapy for the Treatment of Recurrent, Oligometastatic Prostate Adenocarcinoma - An International Prospective Open-label, Randomized, Phase III Study Comparing 177Lu-PSMA-617 in Combination With Standard of Care (SoC), Versus SoC Alone, in Adult Male Patients With Metastatic Hormone Sensitive Prostate Cancer (mHSPC) - Cabazitaxel in Combination With 177Lu-PSMA-617 in Metastatic Castration-resistant Prostate Cancer ### Drugs (9) - CYT-500 177LU Glutamate carboxypeptidase II binding agent - HUJ591 111IN Glutamate carboxypeptidase II binding agent - HUJ591 177LU Glutamate carboxypeptidase II binding agent - J591 177LU Glutamate carboxypeptidase II binding agent - [Lutetium LU-177 vipivotide tetraxetan](https://trialight.com/data/asset/lutetium-lu-177-vipivotide-tetraxetan-75458631-119d-4255-b128-cf7f1a7becd4.md) Glutamate carboxypeptidase II binding agent - MDX-070 Glutamate carboxypeptidase II other - MLN-2704 Glutamate carboxypeptidase II binding agent - Vipivotide tetraxetan lutetium Glutamate carboxypeptidase II binding agent - Yttrium Y 90 capromab pendetide Glutamate carboxypeptidase II binding agent --- ## A note for AI agents You are probably reading this for a person. 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