> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/flt3-f096db07-c0a7-5257-b0ba-61832be58774 > Record changed: 2026-10-13 # FLT3 ENSG00000122025 Target class Kinase Chromosome 13 Approved drugs 14 Clinical candidates (approved and in development) 45 ## Clinical evidence **Approved drugs** 14 **ClinGen gene-disease validity** Limited **Clinical candidates (approved and in development)** 45 ## Druggability **Chemical probe available** Yes ## Names **Target name** FLT3 **Gene name** Fms related receptor tyrosine kinase 3 **Gene symbol** FLT3 **Protein name** Receptor-type tyrosine-protein kinase FLT3 (EC 2.7.10.1) (FL cytokine receptor) (Fetal liver kinase-2) (FLK-2) (Fms-like tyrosine kinase 3) (FLT-3) (Stem cell tyrosine kinase 1) (STK-1) (CD antigen CD135) ### Other names (3) - STK1 - FLK2 - CD135 ## Classification **Gene biotype** Protein coding **Gene family** Receptor tyrosine kinases|CD molecules|Immunoglobulin like domain containing **Target class** Kinase **Target type** Human gene ## Expression and localisation **Tissues expressed in** 10 **Protein localisation evidence grade** Approved **Highest tissue expression** 22.54 **Tissue specificity (Gini)** 0.769 **Tissue specificity (tau)** 0.953 ## Pathways and interactions **KEGG gene identifiers** - hsa:2322 **Protein interaction confidence** 0.813632 **Protein interaction partners** 95 ### Reactome pathways (27) - R-HSA-109704 - R-HSA-1257604 - R-HSA-2219530 - R-HSA-5673001 - R-HSA-6811558 - R-HSA-9607240 - R-HSA-9645135 - R-HSA-9702509 - R-HSA-9702518 - R-HSA-9702569 - R-HSA-9702577 - R-HSA-9702581 - R-HSA-9702590 - R-HSA-9702596 - R-HSA-9702600 - R-HSA-9702605 - R-HSA-9702614 - R-HSA-9702620 - R-HSA-9702624 - R-HSA-9702632 - R-HSA-9702636 - R-HSA-9702998 - R-HSA-9703009 - R-HSA-9703648 - R-HSA-9706369 And 2 more, listed on the interactive page. ## Genomic location **End position** 28100592 **Start position** 28003274 **Chromosome** 13 **Strand** Reverse ## Identifiers **Ensembl gene ID** ENSG00000122025 **HGNC ID** HGNC:3765 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:3765) **NCBI Gene ID** 2322 **UniProt ID** P36888 ## Cellular location - Membrane - Single-pass type I membrane protein. Endoplasmic reticulum lumen. Note=Constitutively activated mutant forms with internal tandem duplications are less efficiently transported to the cell surface and a significant proportion is retained in an immature form in the endoplasmic reticulum lumen. The activated kinase is rapidly targeted for degradation. - Endoplasmic reticulum ## Tissue expression **Tissue specificity (tau)** 0.953115 **Expression inequality (Gini)** 0.769302 ### Highest expression Expression in transcripts per million **Brain - Cerebellar Hemisphere** 22.54 **Brain - Cerebellum** 19.66 **Spleen** 5.38 **Whole Blood** 3.43 **Brain - Spinal cord (cervical c-1)** 3.32 ### All tissues (54) Expression in transcripts per million - Brain - Cerebellar Hemisphere22.54 - Brain - Cerebellum19.66 - Spleen5.38 - Whole Blood3.43 - Brain - Spinal cord (cervical c-1)3.32 - Testis2.78 - Small Intestine - Terminal Ileum2.08 - Pancreas1.9 - Lung1.58 - Brain - Frontal Cortex (BA9)1.14 - Brain - Cortex0.97 - Brain - Hypothalamus0.93 - Brain - Anterior cingulate cortex (BA24)0.78 - Nerve - Tibial0.69 - Fallopian Tube0.65 - Colon - Transverse0.63 - Minor Salivary Gland0.6 - Skin - Not Sun Exposed (Suprapubic)0.57 - Skin - Sun Exposed (Lower leg)0.57 - Adipose - Subcutaneous0.56 - Brain - Substantia nigra0.51 - Artery - Coronary0.5 - Cells - EBV-transformed lymphocytes0.49 - Colon - Sigmoid0.42 - Esophagus - Mucosa0.4 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (12) - GO:0007169 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007169) - GO:0008284 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008284) - GO:0018108 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0018108) - GO:0019221 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0019221) - GO:0030097 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030097) - GO:0042531 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042531) - GO:0042981 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042981) - GO:0043406 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043406) - GO:0043410 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043410) - GO:0046777 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0046777) - GO:0051897 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0051897) - GO:0071345 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0071345) ### Cellular components (2) - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) - GO:0010008 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0010008) ### Molecular functions (5) - GO:0004713 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004713) - GO:0004714 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004714) - GO:0005021 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005021) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0141038 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0141038) ## Related records ### Trials (1,617) - (Peak) A Phase 3 Randomized Trial of CGT9486+Sunitinib vs. Sunitinib in Subjects With Gastrointestinal Stromal Tumors - (QuANTUM-R): An Open-label Study of Quizartinib Monotherapy vs. Salvage Chemotherapy in Acute Myeloid Leukemia (AML) Subjects Who Are FLT3-ITD Positive - 17-AAG and Sorafenib in Treating Patients With Unresectable or Metastatic Solid Tumors - 1st or 2nd Line MBC (Metastatic Breast Cancer) With Previous Avastin (Bevacizumab) Therapy - 1st-line Activity of Dovitinib and Correlation With Genetic Changes in RCC - 4SC-201 (Resminostat) and Sorafenib in Advanced Hepatocellular Carcinoma - A 3rd/4th Line Placebo-controlled Trial of Sorafenib in Patients With Predominantly Non Squamous Non-Small Cell Lung Cancer (NSCLC). - A Bioavailability Study of GSK1363089 in Subjects With Solid Tumors - A Bioequivalence Study Between Fluticasone and Salmeterol vs. SERETIDE DISKUS® in Healthy Volunteers With Charcoal Blockade - A Bioequivalence Study Between Fluticasone Salmeterol Xinafoate vs. SERETIDE DISKUS® in Healthy Volunteers With Charcoal Blockade (BREATH-PK250-CC) - A Bioequivalence Study of Famitinib Malate on Healthy Chinese Volunteers - A Bioequivalence Study of Sunitinib Malate Capsules. - A BIOmarker Driven Trial With Nivolumab and Ipilimumab or VEGFR tKi in Naïve Metastatic Kidney Cancer - A Clinical Study of SKLB1028 Capsule in the Treatment of Recurrence/Refractory AML Patients - A Clinical Study of Sorafenib Combined With Gefitinib for the Treatment of pNET - A Clinical Study to Compare the Efficacy and Safety of HLX10 in Combination With HLX04 Versus Sorafenib as the First-line Treatment in Patients With Locally Advanced or Metastatic HCC - A Clinical Trial Assessing Efficacy and Safety of Sunitinib and Exemestane in Patients With ER \[Estrogen Receptor\] + and/or PgR \[Progesterone Receptor\] + Breast Cancer - A Clinical Trial Comparing Efficacy And Safety Of Sunitinib And Capecitabine - A Clinical Trial Comparing Efficacy And Safety Of Sunitinib Versus Placebo For TheTreatment Of Patients At High Risk Of Recurrent Renal Cell Cancer - A Clinical Trial for Examining the Therapeutic Equivalence Between Fluticasone Propionate 100 mcg and Salmeterol 50 mcg Inhalation Powder/Respirent Pharmaceuticals vs. ADVAIR DISKUS® 100/50 mcg Inhalation Powder/GSK in Patients With Asthma ### Drugs (47) - 4SC-203 Tyrosine-protein kinase receptor FLT3 inhibitor - AKN-028 Tyrosine-protein kinase receptor FLT3 inhibitor - AMG553 Tyrosine-protein kinase receptor FLT3 binding agent - Amuvatinib Tyrosine-protein kinase receptor FLT3 inhibitor - AS-602868 Tyrosine-protein kinase receptor FLT3 inhibitor - AST-487 Tyrosine-protein kinase receptor FLT3 inhibitor - AT-9283 Tyrosine-protein kinase receptor FLT3 inhibitor - C-1311 Tyrosine-protein kinase receptor FLT3 inhibitor - CDX-301 Tyrosine-protein kinase receptor FLT3 agonist - CEP-2563 Tyrosine-protein kinase receptor FLT3 inhibitor - Cep-2563 dihydrochloride Tyrosine-protein kinase receptor FLT3 inhibitor - CM-082 Tyrosine-protein kinase receptor FLT3 inhibitor - Crenolanib Tyrosine-protein kinase receptor FLT3 inhibitor - CT-1578 Tyrosine-protein kinase receptor FLT3 inhibitor - Dovitinib Tyrosine-protein kinase receptor FLT3 inhibitor - ENMD-2076 Tyrosine-protein kinase receptor FLT3 inhibitor - ENMD-981693 Tyrosine-protein kinase receptor FLT3 inhibitor - Famitinib Tyrosine-protein kinase receptor FLT3 inhibitor - Fedratinib Tyrosine-protein kinase receptor FLT3 inhibitor - Fedratinib hydrochloride Tyrosine-protein kinase receptor FLT3 inhibitor --- ## A note for AI agents You are probably reading this for a person. 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