> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/flt1-2cfcec95-3fff-5be9-8423-701697547fa0 > Record changed: 2026-10-13 # FLT1 ENSG00000102755 Target class Kinase Chromosome 13 Approved drugs 12 Clinical candidates (approved and in development) 47 ## Clinical evidence **Approved drugs** 12 **Clinical candidates (approved and in development)** 47 ## Druggability **Chemical probe available** Yes ## Names **Other names** - VEGFR1 **Target name** FLT1 **Gene name** Fms related receptor tyrosine kinase 1 **Gene symbol** FLT1 **Previous gene symbols** - FLT **Protein name** Vascular endothelial growth factor receptor 1 (VEGFR-1) (EC 2.7.10.1) (Fms-like tyrosine kinase 1) (FLT-1) (Tyrosine-protein kinase FRT) (Tyrosine-protein kinase receptor FLT) (FLT) (Vascular permeability factor receptor) ## Classification **Gene biotype** Protein coding **Gene family** Receptor tyrosine kinases|V-set domain containing|I-set domain containing **Target class** Kinase **Target type** Human gene ## Expression and localisation **Tissues expressed in** 53 **Protein localisation evidence grade** Supported **Highest tissue expression** 54.17 **Tissue specificity (Gini)** 0.359 **Tissue specificity (tau)** 0.803 ## Pathways and interactions **KEGG gene identifiers** - hsa:2321 **Protein interaction confidence** 0.838105 **Protein interaction partners** 86 ### Reactome pathways (2) - R-HSA-194306 - R-HSA-195399 ## Genomic location **End position** 28495145 **Start position** 28300346 **Chromosome** 13 **Strand** Reverse ## Identifiers **Ensembl gene ID** ENSG00000102755 **HGNC ID** HGNC:3763 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:3763) **NCBI Gene ID** 2321 **UniProt ID** P17948 ## Cellular location - \[Isoform 1\]: Cell membrane - Single-pass type I membrane protein. Endosome. Note=Autophosphorylation promotes ubiquitination and endocytosis. - SUBCELLULAR LOCATION: \[Isoform 2\]: Secreted . - SUBCELLULAR LOCATION: \[Isoform 3\]: Secreted. - SUBCELLULAR LOCATION: \[Isoform 4\]: Secreted. - SUBCELLULAR LOCATION: \[Isoform 5\]: Cytoplasm . - SUBCELLULAR LOCATION: \[Isoform 6\]: Cytoplasm . - SUBCELLULAR LOCATION: \[Isoform 7\]: Cytoplasm . - Actin filaments - Cytosol - Plasma membrane ### Publication evidence - PubMed 8248162 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/8248162/) ## Tissue expression **Tissue specificity (tau)** 0.803083 **Expression inequality (Gini)** 0.358525 ### Highest expression Expression in transcripts per million **Thyroid** 54.17 **Adipose - Visceral (Omentum)** 35.69 **Adipose - Subcutaneous** 28.61 **Lung** 25.39 **Breast - Mammary Tissue** 25.34 ### All tissues (54) Expression in transcripts per million - Thyroid54.17 - Adipose - Visceral (Omentum)35.69 - Adipose - Subcutaneous28.61 - Lung25.39 - Breast - Mammary Tissue25.34 - Uterus21.51 - Cervix - Endocervix16.81 - Kidney - Cortex15.69 - Cervix - Ectocervix15.59 - Nerve - Tibial14.61 - Brain - Spinal cord (cervical c-1)14.53 - Brain - Substantia nigra14.43 - Heart - Atrial Appendage14.16 - Fallopian Tube13.68 - Prostate13.62 - Artery - Coronary13.28 - Heart - Left Ventricle12.6 - Kidney - Medulla11.81 - Brain - Caudate (basal ganglia)11 - Brain - Frontal Cortex (BA9)10.38 - Brain - Cerebellar Hemisphere10.33 - Brain - Hippocampus10.29 - Brain - Hypothalamus10.21 - Esophagus - Muscularis10.14 - Brain - Putamen (basal ganglia)10.05 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (15) - GO:0002548 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0002548) - GO:0007169 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007169) - GO:0008284 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008284) - GO:0016477 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016477) - GO:0018108 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0018108) - GO:0030335 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030335) - GO:0035924 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0035924) - GO:0036323 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0036323) - GO:0043406 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043406) - GO:0043410 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043410) - GO:0045766 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045766) - GO:0046777 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0046777) - GO:0048010 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0048010) - GO:0051897 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0051897) - GO:1905563 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1905563) ### Cellular components (4) - GO:0005576 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005576) - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) - GO:0005925 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005925) - GO:0043235 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043235) ### Molecular functions (6) - GO:0004713 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004713) - GO:0004714 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004714) - GO:0005021 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005021) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0019838 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0019838) - GO:0036332 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0036332) ## On-target safety - impaired healing ### Effects - Inhibition/Decrease/Downregulation ### Studies - clinical PubMed 38773351 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/38773351/) - brain natriuretic peptide increase ### Effects - Inhibition/Decrease/Downregulation ### Studies - clinical ### Biological samples - metabolic/endocrine PubMed 38773351 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/38773351/) - heart disease ### Studies - preclinical: Highly important for the heart and vasculature based on findings in genetically modified or kinase-inhibitor-treated mice. Role of kinase in heart/vasculature: Crucial in angiogenesis and the heart’s response to pressure overload; antihypertensive effects ### Biological samples - cardiovascular system PubMed 21283106 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/21283106/) - Increased, Developmental Defects ### Effects - Inhibition/Decrease/Downregulation ### Studies - cell-based Evidence source Source: [aopwiki.org](https://aopwiki.org/aops/43) - hyponatraemia ### Effects - Inhibition/Decrease/Downregulation ### Studies - clinical ### Biological samples - metabolism PubMed 38773351 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/38773351/) - Haemorrhage ### Effects - Inhibition/Decrease/Downregulation ### Studies - clinical ### Biological samples - CV PubMed 38773351 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/38773351/) - hypertension ### Effects - Inhibition/Decrease/Downregulation ### Studies - clinical ### Biological samples - CV PubMed 38773351 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/38773351/) ## Off-target safety - regulation of catalytic activity ### Studies (2) - biochemical: NVS\_ENZ\_hVEGFR1, is one of one assay component(s) measured or calculated from the NVS\_ENZ\_hVEGFR1 assay. It is designed to make measurements of enzyme activity, a form of enzyme reporter, as detected with fluorescence intensity signals by Fluorescence and electrophoretic mobility shift technology. - biochemical: NVS\_ENZ\_hVEGFR1, is one of one assay component(s) measured or calculated from the NVS\_ENZ\_hVEGFR1 assay. It is designed to make measurements of enzyme activity, a form of enzyme reporter, as detected with fluorescence intensity signals by Fluorescence and electrophoretic mobility shift technology. ### Biological samples - cell-free Evidence source Source: [www.epa.gov](https://www.epa.gov/chemical-research/exploring-toxcast-data-downloadable-data) ## Related records ### Trials (3,458) - - IKF/AIO-QUINTIS - Evaluating Fruquintinib in Combination With Tislelizumab in Microsatellite Stable / Proficient Mismatch Repair (MSS/pMMR) Metastatic Colorectal Cancer Without Active Liver Metastases - : A Phase Ib/II Study To Evaluate Fruquintinib Monotherapy Or Plus Sintilimab In Advanced Solid Tumors - "Thymalfasin Immunotherapy Study with Triple Regimen in Advanced MSS/pMMR Colorectal Cancer" - (Peak) A Phase 3 Randomized Trial of CGT9486+Sunitinib vs. Sunitinib in Subjects With Gastrointestinal Stromal Tumors - (VOYAGER) Study of Avapritinib vs Regorafenib in Patients With Locally Advanced Unresectable or Metastatic GIST - \[18F\]FLT-PET as a Predictive Imaging Biomaker of Treatment Responses to Regorafenib - \[18F\]Fluciclatide-PET, Pazopanib and Paclitaxel in Ovarian Cancer - \[18F\]Fluoroestradiol-PET/CT Companion Imaging Study to the FORESEE Trial - \[18F\]Fluoroestradiol-PET/CT Imaging of Invasive Lobular Carcinoma - \[68 Ga\]-DOTANOC PET/CT in GEP-NETs - \[68Ga\]Ga-FAPI-46 in Staging of Head and Neck Carcinomas - \[68Ga\]Ga-PentixaFor PET/CT in Acute Myocardial Inflammation - 11C-methionine in Diagnostics and Management of Glioblastoma Multiforme Patients (GlioMET) - 12 Week Patient Study in Neovascular Age-related Macular Degeneration (AMD) - 17-AAG and Sorafenib in Treating Patients With Unresectable or Metastatic Solid Tumors - 18F-DCFBC PET/CT in Prostate Cancer - 18F-DCFPyL Positron Emission Tomography (PET)/Computed Tomography (CT) in Men With Prostate Cancer - 1st or 2nd Line MBC (Metastatic Breast Cancer) With Previous Avastin (Bevacizumab) Therapy - 1st-line Activity of Dovitinib and Correlation With Genetic Changes in RCC - 4SC-201 (Resminostat) and Sorafenib in Advanced Hepatocellular Carcinoma ### Drugs (52) - 4SC-203 Vascular endothelial growth factor receptor inhibitor - AEE-788 Vascular endothelial growth factor receptor 1 inhibitor - AG-13958 Vascular endothelial growth factor receptor inhibitor - AGN-211745 VEGFR1 mRNA rnai inhibitor - Axitinib Vascular endothelial growth factor receptor inhibitor - BMS-690514 Vascular endothelial growth factor receptor inhibitor - Brivanib Vascular endothelial growth factor receptor inhibitor - Brivanib alaninate Vascular endothelial growth factor receptor inhibitor - Cediranib Vascular endothelial growth factor receptor inhibitor - [CEP-11981](https://trialight.com/data/asset/cep-11981-b221c5f0-2453-4f9c-b8b4-15a86c81e937.md) Vascular endothelial growth factor receptor inhibitor - CEP-5214 Vascular endothelial growth factor receptor inhibitor - CEP-7055 Vascular endothelial growth factor receptor inhibitor - CP-459632 Vascular endothelial growth factor receptor inhibitor - Dovitinib Vascular endothelial growth factor receptor inhibitor - Famitinib Vascular endothelial growth factor receptor 1 inhibitor - Foretinib Vascular endothelial growth factor receptor inhibitor - [Fruquintinib](https://trialight.com/data/asset/fruquintinib-e15c1522-cabe-4f7b-a918-3ca55e1ef88a.md) Vascular endothelial growth factor receptor inhibitor - Glesatinib Vascular endothelial growth factor receptor inhibitor - Ibcasertib Vascular endothelial growth factor receptor inhibitor - Icrucumab Vascular endothelial growth factor receptor 1 antagonist --- ## A note for AI agents You are probably reading this for a person. 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