> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/target/flna-4b287f5e-49e9-57b5-819e-b4f59359640b
> Record changed: 2026-10-13

# FLNA

ENSG00000196924

Target class

Unclassified protein

Chromosome

X

Approved drugs

0

Clinical candidates (approved and in development)

1

## Clinical evidence

**Approved drugs**

0

**ClinGen gene-disease validity**

Definitive

**Clinical candidates (approved and in development)**

1

## Druggability

**Chemical probe available**

No

## Names

**Other names**

- ABP-280

**Target name**

FLNA

**Gene name**

Filamin A

**Gene symbol**

FLNA

**Protein name**

Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin)

### Previous gene symbols (4)

- FLN1
- FLN
- OPD2
- OPD1

## Classification

**Gene biotype**

Protein coding

**Gene family**

Filamin family

**Target class**

Unclassified protein

**Target type**

Human gene

## Expression and localisation

**Tissues expressed in**

54

**Protein localisation evidence grade**

Supported

**Highest tissue expression**

4,950.86

**Tissue specificity (Gini)**

0.697

**Tissue specificity (tau)**

0.854

## Pathways and interactions

**KEGG gene identifiers**

- hsa:2316

**Protein interaction confidence**

0.840545

**Protein interaction partners**

101

### Reactome pathways (5)

- R-HSA-114608
- R-HSA-430116
- R-HSA-446353
- R-HSA-5627123
- R-HSA-8983711

## Genomic location

**End position**

154374638

**Start position**

154348524

**Chromosome**

X

**Strand**

Reverse

## Identifiers

**Ensembl gene ID**

ENSG00000196924

**HGNC ID**

HGNC:3754

Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:3754)

**NCBI Gene ID**

2316

**UniProt ID**

P21333

## Cellular location

- Cytoplasm, cell cortex . Cytoplasm, cytoskeleton . Perikaryon . Cell projection, growth cone . Cell projection, podosome . Note=Colocalizes with CPMR1 in the central region of DRG neuron growth cone (By similarity). Following SEMA3A stimulation of DRG neurons, colocalizes with F-actin (By similarity). Localized to the core of myotube podosomes (By similarity). .
- Actin filaments
- Cytosol
- Plasma membrane

### Publication evidence

- PubMed 16291724  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/16291724/)

## Tissue expression

**Tissue specificity (tau)**

0.853632

**Expression inequality (Gini)**

0.697499

### Highest expression

Expression in transcripts per million

**Artery - Tibial**

4,950.86

**Colon - Sigmoid**

3,958.63

**Esophagus - Muscularis**

3,824.37

**Artery - Aorta**

3,732.42

**Esophagus - Gastroesophageal Junction**

3,727.98

### All tissues (54)

Expression in transcripts per million

- Artery - Tibial4,950.86
- Colon - Sigmoid3,958.63
- Esophagus - Muscularis3,824.37
- Artery - Aorta3,732.42
- Esophagus - Gastroesophageal Junction3,727.98
- Uterus2,918.58
- Artery - Coronary2,747.03
- Bladder2,335.29
- Fallopian Tube2,233.5
- Cervix - Endocervix1,397.7
- Colon - Transverse1,065.11
- Cervix - Ectocervix1,014.89
- Prostate942.08
- Cells - Cultured fibroblasts931.78
- Lung700.52
- Vagina696.82
- Nerve - Tibial632.23
- Ovary615.82
- Adipose - Subcutaneous524.05
- Breast - Mammary Tissue401.9
- Adipose - Visceral (Omentum)380.38
- Esophagus - Mucosa326.73
- Small Intestine - Terminal Ileum309.96
- Spleen265.18
- Skin - Sun Exposed (Lower leg)255.98

And 29 more, listed on the interactive page.

## Biological functions

### Biological processes (24)

- GO:0007195  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007195)
- GO:0016479  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016479)
- GO:0030036  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030036)
- GO:0030334  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030334)
- GO:0034394  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0034394)
- GO:0042177  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042177)
- GO:0042307  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042307)
- GO:0043066  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043066)
- GO:0043113  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043113)
- GO:0043123  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043123)
- GO:0044319  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0044319)
- GO:0045184  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045184)
- GO:0050821  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0050821)
- GO:0051764  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0051764)
- GO:0060271  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0060271)
- GO:0070527  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070527)
- GO:0071526  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0071526)
- GO:0072659  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0072659)
- GO:0090042  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0090042)
- GO:0090307  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0090307)
- GO:1900026  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1900026)
- GO:1901381  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1901381)
- GO:1905000  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1905000)
- GO:2001046  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:2001046)

### Cellular components (12)

- GO:0005576  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005576)
- GO:0005634  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005634)
- GO:0005730  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005730)
- GO:0005737  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005737)
- GO:0005829  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005829)
- GO:0005886  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886)
- GO:0005911  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005911)
- GO:0005925  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005925)
- GO:0015629  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0015629)
- GO:0016020  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016020)
- GO:0031523  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0031523)
- GO:0070062  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070062)

### Molecular functions (14)

- GO:0001664  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0001664)
- GO:0003723  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0003723)
- GO:0005515  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515)
- GO:0015459  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0015459)
- GO:0019900  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0019900)
- GO:0031267  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0031267)
- GO:0034988  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0034988)
- GO:0042803  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042803)
- GO:0044325  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0044325)
- GO:0045296  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045296)
- GO:0051015  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0051015)
- GO:0051020  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0051020)
- GO:0140297  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0140297)
- GO:0140311  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0140311)

## Related records

### Trials (11)

- A Pharmacokinetic Study of Simufilam in Subjects With Impaired Hepatic Function
- A Safety Study of PTI-125 in Healthy Volunteers
- Food Effect and Bioequivalence Study of Simufilam Tablets in Healthy Volunteers
- [Open-label Extension for Phase 3 Clinical Trials of Simufilam](https://trialight.com/data/trial/open-label-extension-for-phase-3-clinical-trials-of-8fc7dab4-9287-4c4f-9aa6-306390f58813.md)
- Open-Label Extension of the PTI-125-04 Study in Mild-to-Moderate Alzheimer's Disease
- Open-label Study of the Absorption, Metabolism, and Excretion of \[14C\]-Simufilam Following a Single Oral Dose in Healthy Male Subjects
- PTI-125 for Mild-to-moderate Alzheimer's Disease Patients
- PTI-125 for Mild-to-moderate Alzheimer's Disease Patients
- Simufilam (PTI-125), 100 mg, for Mild-to-moderate Alzheimer's Disease Patients
- Simufilam 100 mg for Mild-to-Moderate Alzheimer's Disease
- [Simufilam 50 mg or 100 mg for Mild-to-Moderate Alzheimer's Disease](https://trialight.com/data/trial/simufilam-50-mg-or-100-mg-for-mild-to-moderate-alzheimer-s-38890b73-0102-4424-a366-3e1188fbdc9c.md)

### Drugs (1)

- [Simufilam](https://trialight.com/data/asset/simufilam-bc5cff9c-b790-4165-8b52-9897decc6257.md) Filamin-A positive modulator

---

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