> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/fkbp1a-caa2dbe9-c679-5ba2-9bd0-18b303620352 > Record changed: 2026-10-13 # FKBP1A ENSG00000088832 Target class Enzyme Chromosome 20 Approved drugs 5 Clinical candidates (approved and in development) 7 ## Clinical evidence **Approved drugs** 5 **Clinical candidates (approved and in development)** 7 ## Druggability **Chemical probe available** Yes ## Names **Target name** FKBP1A **Gene name** FKBP prolyl isomerase 1A **Gene symbol** FKBP1A **Previous gene symbols** - FKBP1 **Protein name** Peptidyl-prolyl cis-trans isomerase FKBP1A (PPIase FKBP1A) (EC 5.2.1.8) (12 kDa FK506-binding protein) (12 kDa FKBP) (FKBP-12) (Calstabin-1) (FK506-binding protein 1A) (FKBP-1A) (Immunophilin FKBP12) (Rotamase) ### Other names (5) - FKBP-12 - FKBP12 - PKC12 - PPIASE - FKBP12C ## Classification **Gene biotype** Protein coding **Gene family** FKBP prolyl isomerase family|MicroRNA protein coding host genes **Target class** Enzyme **Target type** Human gene ## Expression and localisation **Tissues expressed in** 54 **Protein localisation evidence grade** Approved **Highest tissue expression** 437.19 **Tissue specificity (Gini)** 0.262 **Tissue specificity (tau)** 0.647 ## Pathways and interactions **KEGG gene identifiers** - hsa:2280 **Protein interaction confidence** 0.821213 **Protein interaction partners** 75 ### Reactome pathways (7) - R-HSA-166208 - R-HSA-2025928 - R-HSA-2173789 - R-HSA-2173791 - R-HSA-3656535 - R-HSA-9679191 - R-HSA-9692916 ## Genomic location **End position** 1393164 **Start position** 1368977 **Chromosome** 20 **Strand** Reverse ## Identifiers **Ensembl gene ID** ENSG00000088832 **HGNC ID** HGNC:3711 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:3711) **NCBI Gene ID** 2280 **UniProt ID** P62942 ## Cellular location - Cytoplasm, cytosol . Sarcoplasmic reticulum membrane - Peripheral membrane protein - Cytoplasmic side . - Cytosol - Golgi apparatus ### Publication evidence - PubMed 1701173 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/1701173/) ## Tissue expression **Tissue specificity (tau)** 0.647288 **Expression inequality (Gini)** 0.262453 ### Highest expression Expression in transcripts per million **Cells - Cultured fibroblasts** 437.19 **Lung** 317.27 **Brain - Nucleus accumbens (basal ganglia)** 305.23 **Adipose - Visceral (Omentum)** 304.8 **Thyroid** 284.35 ### All tissues (54) Expression in transcripts per million - Cells - Cultured fibroblasts437.19 - Lung317.27 - Brain - Nucleus accumbens (basal ganglia)305.23 - Adipose - Visceral (Omentum)304.8 - Thyroid284.35 - Adipose - Subcutaneous272.99 - Cells - EBV-transformed lymphocytes252.03 - Uterus245.28 - Spleen219.48 - Breast - Mammary Tissue214.13 - Brain - Caudate (basal ganglia)212.12 - Artery - Coronary199.8 - Artery - Aorta191.28 - Cervix - Endocervix186.8 - Fallopian Tube184.55 - Ovary181.74 - Nerve - Tibial181.52 - Cervix - Ectocervix181.01 - Vagina169.56 - Esophagus - Mucosa168.82 - Whole Blood168.02 - Brain - Frontal Cortex (BA9)167.19 - Artery - Tibial165.91 - Bladder165.84 - Prostate158.12 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (12) - GO:0006458 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006458) - GO:0014809 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0014809) - GO:0030512 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030512) - GO:0032880 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032880) - GO:0032926 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032926) - GO:0042026 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042026) - GO:0043123 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043123) - GO:0050776 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0050776) - GO:0051604 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0051604) - GO:0097435 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0097435) - GO:1902991 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1902991) - GO:1990000 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1990000) ### Cellular components (4) - GO:0005737 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005737) - GO:0005829 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005829) - GO:0016020 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016020) - GO:0030018 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030018) ### Molecular functions (10) - GO:0003755 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0003755) - GO:0005160 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005160) - GO:0005246 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005246) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0005528 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005528) - GO:0030547 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030547) - GO:0034713 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0034713) - GO:0044325 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0044325) - GO:0070411 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070411) - GO:0070697 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070697) ## Related records ### Trials (2,587) - 1% Topical Pimecrolimus Cream for the Treatment of the Rash Associated With ERBITUX - 10 Year Registry of Children (Ages 2-17 Years) With Eczema That Have Used Pimecrolimus - 10-Years Follow-up of the EXAMINATION Trial - 12 Month Athena Study: Everolimus vs. Standard Regimen in de Novo Kidney Transplant Patients - 131I-apamistamab-based Conditioning for Hematopoietic Stem Cell Transplant (HSCT) in Advanced Sickle Cell Disease (SCD) - 2-Step Approach to Stem Cell Transplant in Treating Participants With Hematological Malignancies - 211At-BC8-B10 Followed by Donor Stem Cell Transplant in Treating Patients With Relapsed or Refractory High-Risk Acute Leukemia or Myelodysplastic Syndrome - 225Ac-DOTA-Anti-CD38 Daratumumab Monoclonal Antibody With Fludarabine, Melphalan and Total Marrow and Lymphoid Irradiation as Conditioning Treatment for Donor Stem Cell Transplant in Patients With High-Risk Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia and Myelodysplastic Syndrome - 24 Month Extension to Efficacy and Safety of AEB071 Plus Tacrolimus (Converted to Mycophenolic Acid After 3 Months) in Renal Transplant Patients(Converted to Mycophenolic Acid After 3 Months) in Renal Transplant Patients - 24 Months Follow-up, Two Arm Study to Compare the Cardiovascular Profile in a Regimen With Everolimus + Mycophenolic Acid (MPA) Versus (vs.) a Regimen of CNI+MPA in Maintenance Renal Transplant Recipients - 3-arm Trial to Evaluate Pasireotide LAR/Everolimus Alone/in Combination in Patients With Lung/Thymus NET - LUNA Trial - 4EVER - Efficacy, Safety, Health Economics, Translational Research of Postmenopausal Women With Estrogen Receptor Positive Locally Advanced or Metastatic Breast Cancer - 5-Year Safety Study of Pimecrolimus Cream 1% in Infants 3 - 12 Months of Age With Mild to Moderate Atopic Dermatitis - 89Zr-bevacizumab PET Imaging in Patients With Neuroendocrine Tumors - A 1-year Comparison of Generic Tacrolimus (Tacni) and Prograf in Renal Transplant Patients - a Retrospective Matched Pair Analysis, GenTac - A 4 Week Study of Elidel (Pimecrolimus) for the Treatment of Seborrheic Dermatitis - A 5 Year Follow-up of Patients Who Were Previously Enrolled Into an Advagraf Trial Following a Liver or Kidney Transplant - A 6-Month Study Of CP-690,550 Versus Tacrolimus In Kidney Transplant Patients - A Biological Prospective Study in Patients With Metastatic Pancreatic NETs Treated With Everolimus - A Blood Stem Cell Transplant for Sickle Cell Disease ### Drugs (8) - [Everolimus](https://trialight.com/data/asset/everolimus-0edf09a9-672d-4f9a-9e34-21ab083a92a4.md) FK506-binding protein 1A inhibitor - Olocrolimus FK506-binding protein 1A inhibitor - Pimecrolimus FK506-binding protein 1A inhibitor - [Sirolimus](https://trialight.com/data/asset/sirolimus-08da04e4-ea95-4587-95c4-83d583e56570.md) FK506-binding protein 1A inhibitor - Tacrolimus FK506-binding protein 1A inhibitor - Tacrolimus anhydrous FK506-binding protein 1A inhibitor - Temsirolimus FK506-binding protein 1A inhibitor - Zotarolimus FK506-binding protein 1A inhibitor --- ## A note for AI agents You are probably reading this for a person. 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