> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/fgr-144930fa-88a9-5a84-b13f-036fc5432bd4 > Record changed: 2026-11-04 # FGR ENSG00000000938 Target class Kinase Chromosome 1 Approved drugs 1 Clinical candidates (approved and in development) 5 ## Clinical evidence **Approved drugs** 1 **Clinical candidates (approved and in development)** 5 ## Druggability **Chemical probe available** No ## Names **Target name** FGR **Gene name** FGR proto-oncogene, Src family tyrosine kinase **Gene symbol** FGR **Previous gene symbols** - SRC2 **Protein name** Tyrosine-protein kinase Fgr (EC 2.7.10.2) (Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog) (Proto-oncogene c-Fgr) (p55-Fgr) (p58-Fgr) (p58c-Fgr) ### Other names (2) - c-fgr - p55c-fgr ## Classification **Gene biotype** Protein coding **Gene family** SH2 domain containing|Src family tyrosine kinases **Target class** Kinase **Target type** Human gene ## Expression and localisation **Tissues expressed in** 53 **Protein localisation evidence grade** Approved **Highest tissue expression** 545.93 **Tissue specificity (Gini)** 0.756 **Tissue specificity (tau)** 0.972 ## Pathways and interactions **KEGG gene identifiers** - hsa:2268 **Protein interaction confidence** 0.832303 **Protein interaction partners** 33 ### Reactome pathways (5) - R-HSA-2029481 - R-HSA-432142 - R-HSA-6798695 - R-HSA-9664323 - R-HSA-9664422 ## Genomic location **End position** 27635565 **Start position** 27612064 **Chromosome** 1 **Strand** Reverse ## Identifiers **Ensembl gene ID** ENSG00000000938 **HGNC ID** HGNC:3697 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:3697) **NCBI Gene ID** 2268 **UniProt ID** P09769 ## Cellular location - Cell membrane - Lipid-anchor - Cytoplasmic side . Cell membrane - Peripheral membrane protein - Cytoplasmic side. Cell projection, ruffle membrane. Cytoplasm, cytosol. Cytoplasm, cytoskeleton. Mitochondrion inner membrane . Mitochondrion intermembrane space . Note=Detected in mitochondrial intermembrane space and at inner membranes (By similarity). Colocalizes with actin fibers at membrane ruffles. Detected at plasma membrane lipid rafts. . - Aggresome - Plasma membrane ## Tissue expression **Tissue specificity (tau)** 0.972032 **Expression inequality (Gini)** 0.756041 ### Highest expression Expression in transcripts per million **Whole Blood** 545.93 **Spleen** 185.64 **Lung** 135.38 **Cells - EBV-transformed lymphocytes** 79.21 **Adipose - Subcutaneous** 28.04 ### All tissues (54) Expression in transcripts per million - Whole Blood545.93 - Spleen185.64 - Lung135.38 - Cells - EBV-transformed lymphocytes79.21 - Adipose - Subcutaneous28.04 - Fallopian Tube27.9 - Adipose - Visceral (Omentum)26.86 - Breast - Mammary Tissue20.47 - Artery - Coronary16.75 - Uterus16.46 - Nerve - Tibial15.89 - Bladder13.99 - Cervix - Endocervix13.92 - Small Intestine - Terminal Ileum12.94 - Thyroid12.36 - Vagina11.26 - Cervix - Ectocervix10.52 - Prostate9.77 - Artery - Aorta8.76 - Esophagus - Gastroesophageal Junction8.23 - Brain - Spinal cord (cervical c-1)7.93 - Esophagus - Muscularis7.88 - Minor Salivary Gland7.63 - Adrenal Gland7.1 - Colon - Sigmoid6.88 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (9) - GO:0002768 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0002768) - GO:0002862 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0002862) - GO:0006468 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006468) - GO:0007229 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007229) - GO:0009615 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0009615) - GO:0018108 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0018108) - GO:0038096 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0038096) - GO:0046777 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0046777) - GO:0051897 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0051897) ### Cellular components (5) - GO:0005576 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005576) - GO:0005829 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005829) - GO:0005856 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005856) - GO:0034774 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0034774) - GO:0070062 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070062) ### Molecular functions (5) - GO:0001784 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0001784) - GO:0004713 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004713) - GO:0004715 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004715) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0034988 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0034988) ## Related records ### Trials (705) - A 3-Part Study to Determine the Relative Bioavailability of Capsule and Tablet Formulations of GDC-0980, the Effect of Food, and the Effect of Rabeprazole on the Pharmacokinetics of the Tablet - A Bioequivalence Study of Dasatinib Tablet - A Clinical Trial Evaluating the Efficacy and Safety of Dasatinib in Refractory Metastatic GIST - A Clinical Trial of Buparlisib and Ibrutinib in Lymphoma - A Crossover Study to Evaluate the Bioavailability of Ibrutinib Suspension and Sprinkle Formulations Compared to Capsules in Healthy Adults - A Dose Escalation and Expansion Study Evaluating the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of RO7283420. - A Drug Interaction Study to Assess the Effect of Omeprazole on the Pharmacokinetics of Ibrutinib in Healthy Adults - A Long-term Extension Study of PCI-32765 (Ibrutinib) - A Multi-Center Study of Ibrutinib in Combination With MEDI4736 in Subjects With Relapsed or Refractory Lymphomas - A Multi-Center Study of Ibrutinib in Combination With MEDI4736 in Subjects With Relapsed or Refractory Solid Tumors - A Multi-Center Study of Ibrutinib in Combination With Obinutuzumab Versus Chlorambucil in Combination With Obinutuzumab in Patients With Treatment naïve Chronic Lymphocytic Leukemia (CLL) or Small Lymphocytic Lymphoma (SLL) - A Multicenter Phase 2 Study of Ibrutinib in Patients With Relapsed or Refractory Chronic Lymphocytic Leukemia (CLL) or Small Lymphocytic Lymphoma (SLL) With 17p Deletion - A Pharmacokinetic Study in Healthy Participants to Assess the Pharmacokinetics and Safety of a Supratherapeutic Dose of PCI-32765 (Ibrutinib) Capsule and Solution Formulations Administered With Food - A Phase 1 Safety Study of TG100801 Eye Drops in Healthy Volunteers - A Phase 1 Study of MKC-1 in Patients With Refractory Hematologic Malignancies - A Phase 1/2, Open-label, Dose Finding Study to Evaluate CC-122 in Combination With Ibrutinib and Obinutuzumab in Subjects With Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma - A Phase 1B Study to Investigate the Safety and Preliminary Efficacy for the Combination of Dasatinib Plus Nivolumab in Patients With Chronic Myeloid Leukemia - A Phase 2 Study of Oral MKC-1 in Patients With Ovarian or Endometrial Cancer - A Phase 3 Study of Ibrutinib (PCI-32765) Versus Ofatumumab in Patients With Relapsed or Refractory Chronic Lymphocytic Leukemia - A Phase I Dose Escalation Combination Study in Patients With Chronic Myelogenous Leukemia (CML) and Philadelphia Chromosome-Positive (Ph+) Acute Lymphoblastic Leukemia (ALL)(0457-009)(TERMINATED) ### Drugs (9) - Apitolisib - Dasatinib - Dasatinib anhydrous SRC inhibitor - Dasatinib laurylsulfate SRC inhibitor - ENMD-981693 SRC inhibitor - [Ibrutinib](https://trialight.com/data/asset/ibrutinib-0b3ac4fd-6e98-4847-a711-2f599e8bb93d.md) - Ilorasertib SRC inhibitor - TG100-801 SRC inhibitor - XL-228 SRC inhibitor --- ## A note for AI agents You are probably reading this for a person. 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