> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/fgfr3-363bb275-8462-51a9-af1c-c621c347ca84 > Record changed: 2026-10-13 # FGFR3 ENSG00000068078 Target class Kinase Chromosome 4 Approved drugs 7 Clinical candidates (approved and in development) 24 ## Clinical evidence **Approved drugs** 7 **ClinGen gene-disease validity** Definitive **Clinical candidates (approved and in development)** 24 ## Druggability **Chemical probe available** Yes ## Names **Target name** FGFR3 **Gene name** Fibroblast growth factor receptor 3 **Gene symbol** FGFR3 **Previous gene symbols** - ACH **Protein name** Fibroblast growth factor receptor 3 (FGFR-3) (EC 2.7.10.1) (CD antigen CD333) ### Other names (3) - CEK2 - JTK4 - CD333 ## Classification **Gene biotype** Protein coding **Gene family** Receptor tyrosine kinases|CD molecules|I-set domain containing **Target class** Kinase **Target type** Human gene ## Expression and localisation **Tissues expressed in** 49 **Protein localisation evidence grade** Supported **Highest tissue expression** 364.55 **Tissue specificity (Gini)** 0.708 **Tissue specificity (tau)** 0.893 ## Pathways and interactions **KEGG gene identifiers** - hsa:2261 **Protein interaction confidence** 0.854135 **Protein interaction partners** 89 ### Reactome pathways (4) - R-HSA-1839130 - R-HSA-2033515 - R-HSA-5655332 - R-HSA-8853334 ## Genomic location **End position** 1808873 **Start position** 1793286 **Chromosome** 4 **Strand** Forward ## Identifiers **Ensembl gene ID** ENSG00000068078 **HGNC ID** HGNC:3690 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:3690) **NCBI Gene ID** 2261 **UniProt ID** P22607 ## Cellular location - \[Isoform 1\]: Cell membrane - Single-pass type I membrane protein. Cytoplasmic vesicle. Endoplasmic reticulum. Note=The activated receptor is rapidly internalized and degraded. Detected in intracellular vesicles after internalization of the autophosphorylated receptor. - SUBCELLULAR LOCATION: \[Isoform 2\]: Cell membrane - Single-pass type I membrane protein . - SUBCELLULAR LOCATION: \[Isoform 3\]: Secreted. - SUBCELLULAR LOCATION: \[Isoform 4\]: Cell membrane - Single-pass type I membrane protein . - Endoplasmic reticulum ## Tissue expression **Tissue specificity (tau)** 0.892542 **Expression inequality (Gini)** 0.708225 ### Highest expression Expression in transcripts per million **Skin - Not Sun Exposed (Suprapubic)** 364.55 **Skin - Sun Exposed (Lower leg)** 356.5 **Esophagus - Mucosa** 199.7 **Brain - Caudate (basal ganglia)** 148.39 **Brain - Nucleus accumbens (basal ganglia)** 135.37 ### All tissues (54) Expression in transcripts per million - Skin - Not Sun Exposed (Suprapubic)364.55 - Skin - Sun Exposed (Lower leg)356.5 - Esophagus - Mucosa199.7 - Brain - Caudate (basal ganglia)148.39 - Brain - Nucleus accumbens (basal ganglia)135.37 - Vagina112.34 - Brain - Cortex109.62 - Brain - Anterior cingulate cortex (BA24)104.69 - Brain - Putamen (basal ganglia)101.3 - Brain - Amygdala94.9 - Brain - Frontal Cortex (BA9)81.13 - Brain - Substantia nigra64.32 - Brain - Cerebellum62.43 - Brain - Hypothalamus53.88 - Pancreas49.25 - Brain - Hippocampus47.91 - Testis39.93 - Kidney - Medulla34.57 - Brain - Cerebellar Hemisphere31.68 - Brain - Spinal cord (cervical c-1)27.03 - Liver25.5 - Pituitary23.81 - Kidney - Cortex23.23 - Colon - Transverse17.17 - Prostate15.63 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (16) - GO:0000165 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0000165) - GO:0001501 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0001501) - GO:0001958 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0001958) - GO:0002062 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0002062) - GO:0003416 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0003416) - GO:0007259 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007259) - GO:0008284 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008284) - GO:0008543 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008543) - GO:0010518 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0010518) - GO:0035988 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0035988) - GO:0042531 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042531) - GO:0043410 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043410) - GO:0051897 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0051897) - GO:0060349 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0060349) - GO:0070374 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070374) - GO:1902178 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1902178) ### Cellular components (5) - GO:0005783 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005783) - GO:0005794 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005794) - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) - GO:0005925 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005925) - GO:0030133 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030133) ### Molecular functions (5) - GO:0004713 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004713) - GO:0005007 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005007) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0017134 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0017134) - GO:0042802 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042802) ## Off-target safety - regulation of catalytic activity ### Studies - biochemical: NVS\_ENZ\_hFGFR3, is one of one assay component(s) measured or calculated from the NVS\_ENZ\_hFGFR3 assay. It is designed to make measurements of enzyme activity, a form of enzyme reporter, as detected with fluorescence intensity signals by Fluorescence and electrophoretic mobility shift technology. ### Biological samples - cell-free Evidence source Source: [www.epa.gov](https://www.epa.gov/chemical-research/exploring-toxcast-data-downloadable-data) ## Related records ### Trials (761) - \[18F\]Fluciclatide-PET, Pazopanib and Paclitaxel in Ovarian Cancer - 12 Week Patient Study in Neovascular Age-related Macular Degeneration (AMD) - 1st-line Activity of Dovitinib and Correlation With Genetic Changes in RCC - A BIOmarker Driven Trial With Nivolumab and Ipilimumab or VEGFR tKi in Naïve Metastatic Kidney Cancer - A Combination of Pazopanib and Carboplatin in Advanced Solid Malignancies - A Dose Escalation Study in Adult Patients With Advanced Solid Malignancies - A Dose Escalation Study of BIBF 1120 Together With Paclitaxel and Carboplatin in Patients With Advanced Stage Non-small-cell Lung Cancer - A Dose Escalation Study to Assess the Safety and Tolerability of HMPL-453 in Patients With Advanced Solid Malignancies - A Dose-escalation Study of BIBF 1120 in Japanese Patients With Advanced Solid Tumours - A Dose-Escalation Study of ENMD-2076 Administered Orally to Patients With Advanced Cancer - A Double-blind, Placebo-controlled, Randomized, Parallel-group Study to Evaluate the Activity of Oral AB1010 in Adults Patients With Moderate to Severe Chronic Plaque Psoriasis - A Drug-Drug Interaction Study of ENV-101 (Taladegib) on Nintedanib Pharmacokinetics in Healthy Subjects - A Follow-up Study Investigating Long Term Treatment With Nintedanib in Patients With Progressive Fibrosing Interstitial Lung Disease (PF-ILD) - A Modular Multi-Basket Trial to Improve Personalized Medicine in Cancer Patients (Basket of Baskets) - A Multi-center, Open-label Study of Oral ENMD-2076 for the Treatment of Patients With Advanced Fibrolamellar Carcinoma - A Multi-centre 3-arm Randomised Phase II Trial of BIBF 1120 Versus BIBW 2992 Versus Sequential Administration of BIBF 1120 and BIBW 2992 in Patients With Hormone-resistant Prostate Cancer - A Phase 1 Study of MKC-1 in Patients With Refractory Hematologic Malignancies - A Phase 1 Study of Pegilodecakin (LY3500518) in Participants With Advanced Solid Tumors - A Phase 1B Dose-escalation and Phase 2a Study of Carotuximab (TRC105) in Combination With Pazopanib in Patients With Advanced Soft Tissue Sarcoma - A Phase 1b/2 Clinical Study to Evaluate the Safety and Tolerability and Efficacy of AZD4547 ### Drugs (26) - Brivanib Fibroblast growth factor receptor inhibitor - Brivanib alaninate Fibroblast growth factor receptor inhibitor - CP-459632 Fibroblast growth factor receptor inhibitor - Derazantinib Fibroblast growth factor receptor inhibitor - Dovitinib Fibroblast growth factor receptor 3 inhibitor - E-7090 Fibroblast growth factor receptor 3 inhibitor - ENMD-2076 Fibroblast growth factor receptor 3 inhibitor - ENMD-981693 Fibroblast growth factor receptor inhibitor - Erdafitinib Fibroblast growth factor receptor inhibitor - Fexagratinib Fibroblast growth factor receptor inhibitor - Fgfr inhibitor debio 1347 Fibroblast growth factor receptor 3 inhibitor - Futibatinib Fibroblast growth factor receptor inhibitor - HMPL-453 Fibroblast growth factor receptor 3 inhibitor - Infigratinib Fibroblast growth factor receptor inhibitor - [Infigratinib phosphate](https://trialight.com/data/asset/infigratinib-phosphate-0d4981cb-450a-4f7e-9abd-dd3fccddcea8.md) Fibroblast growth factor receptor inhibitor - LY-2874455 Fibroblast growth factor receptor inhibitor - Masitinib Fibroblast growth factor receptor 3 inhibitor - Nintedanib Fibroblast growth factor receptor inhibitor - Nintedanib esylate Fibroblast growth factor receptor inhibitor - Orantinib Fibroblast growth factor receptor inhibitor --- ## A note for AI agents You are probably reading this for a person. 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