> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/target/fgfr2-fe40fa89-06a8-5027-ad17-dc2ec2e9ebcd
> Record changed: 2026-10-13

# FGFR2

ENSG00000066468

Target class

Kinase

Chromosome

10

Approved drugs

9

Clinical candidates (approved and in development)

27

## Clinical evidence

**Approved drugs**

9

**ClinGen gene-disease validity**

Definitive

**Clinical candidates (approved and in development)**

27

## Druggability

**Chemical probe available**

Yes

## Names

**Target name**

FGFR2

**Gene name**

Fibroblast growth factor receptor 2

**Gene symbol**

FGFR2

**Protein name**

Fibroblast growth factor receptor 2 (FGFR-2) (EC 2.7.10.1) (K-sam) (KGFR) (Keratinocyte growth factor receptor) (CD antigen CD332)

### Other names (6)

- CEK3
- TK14
- TK25
- ECT1
- K-SAM
- CD332

### Previous gene symbols (4)

- KGFR
- BEK
- CFD1
- JWS

## Classification

**Gene biotype**

Protein coding

**Gene family**

Receptor tyrosine kinases|CD molecules|I-set domain containing

**Target class**

Kinase

**Target type**

Human gene

## Expression and localisation

**Tissues expressed in**

47

**Protein localisation evidence grade**

Approved

**Highest tissue expression**

130.14

**Tissue specificity (Gini)**

0.485

**Tissue specificity (tau)**

0.886

## Pathways and interactions

**KEGG gene identifiers**

- hsa:2263

**Protein interaction confidence**

0.852214

**Protein interaction partners**

103

### Reactome pathways (5)

- R-HSA-2023837
- R-HSA-2033519
- R-HSA-5655253
- R-HSA-8851708
- R-HSA-8853333

## Genomic location

**End position**

121598458

**Start position**

121478332

**Chromosome**

10

**Strand**

Reverse

## Identifiers

**Ensembl gene ID**

ENSG00000066468

**HGNC ID**

HGNC:3689

Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:3689)

**NCBI Gene ID**

2263

**UniProt ID**

P21802

## Cellular location

- Cell membrane
- Single-pass type I membrane protein. Golgi apparatus. Cytoplasmic vesicle. Note=Detected on osteoblast plasma membrane lipid rafts. After ligand binding, the activated receptor is rapidly internalized and degraded.
- SUBCELLULAR LOCATION: \[Isoform 1\]: Cell membrane
- Single-pass type I membrane protein. Note=After ligand binding, the activated receptor is rapidly internalized and degraded.
- SUBCELLULAR LOCATION: \[Isoform 3\]: Cell membrane
- Single-pass type I membrane protein. Note=After ligand binding, the activated receptor is rapidly internalized and degraded.
- SUBCELLULAR LOCATION: \[Isoform 8\]: Secreted.
- SUBCELLULAR LOCATION: \[Isoform 13\]: Secreted.
- Cell Junctions
- Nucleoplasm
- Vesicles

## Tissue expression

**Tissue specificity (tau)**

0.885527

**Expression inequality (Gini)**

0.485194

### Highest expression

Expression in transcripts per million

**Brain - Spinal cord (cervical c-1)**

130.14

**Uterus**

43.5

**Skin - Sun Exposed (Lower leg)**

41.01

**Colon - Sigmoid**

38.99

**Skin - Not Sun Exposed (Suprapubic)**

37.28

### All tissues (54)

Expression in transcripts per million

- Brain - Spinal cord (cervical c-1)130.14
- Uterus43.5
- Skin - Sun Exposed (Lower leg)41.01
- Colon - Sigmoid38.99
- Skin - Not Sun Exposed (Suprapubic)37.28
- Brain - Substantia nigra33.68
- Brain - Cerebellum31.42
- Thyroid30.6
- Brain - Putamen (basal ganglia)26.97
- Minor Salivary Gland24.11
- Cervix - Endocervix23.44
- Brain - Hippocampus23.39
- Brain - Caudate (basal ganglia)22.88
- Vagina21.79
- Brain - Cortex21.69
- Esophagus - Muscularis21.6
- Brain - Frontal Cortex (BA9)20.3
- Brain - Amygdala19.54
- Prostate19.52
- Colon - Transverse17.74
- Cervix - Ectocervix17.57
- Bladder16.01
- Brain - Nucleus accumbens (basal ganglia)15.95
- Brain - Anterior cingulate cortex (BA24)15.94
- Brain - Cerebellar Hemisphere15.68

And 29 more, listed on the interactive page.

## Biological functions

### Biological processes (11)

- GO:0008284  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008284)
- GO:0008543  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008543)
- GO:0010518  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0010518)
- GO:0010839  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0010839)
- GO:0018108  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0018108)
- GO:0033688  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0033688)
- GO:0043410  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043410)
- GO:0045667  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045667)
- GO:0046777  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0046777)
- GO:0048701  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0048701)
- GO:0048705  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0048705)

### Cellular components (5)

- GO:0005634  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005634)
- GO:0005737  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005737)
- GO:0005886  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886)
- GO:0005938  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005938)
- GO:0009986  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0009986)

### Molecular functions (5)

- GO:0004713  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004713)
- GO:0005007  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005007)
- GO:0005515  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515)
- GO:0017134  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0017134)
- GO:0042803  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042803)

## Related records

### Trials (887)

- "Thymalfasin Immunotherapy Study with Triple Regimen in Advanced MSS/pMMR Colorectal Cancer"
- (VOYAGER) Study of Avapritinib vs Regorafenib in Patients With Locally Advanced Unresectable or Metastatic GIST
- \[18F\]FLT-PET as a Predictive Imaging Biomaker of Treatment Responses to Regorafenib
- \[18F\]Fluoroestradiol-PET/CT Companion Imaging Study to the FORESEE Trial
- \[18F\]Fluoroestradiol-PET/CT Imaging of Invasive Lobular Carcinoma
- \[68 Ga\]-DOTANOC PET/CT in GEP-NETs
- \[68Ga\]Ga-FAPI-46 in Staging of Head and Neck Carcinomas
- \[68Ga\]Ga-PentixaFor PET/CT in Acute Myocardial Inflammation
- 11C-methionine in Diagnostics and Management of Glioblastoma Multiforme Patients (GlioMET)
- 18F-DCFBC PET/CT in Prostate Cancer
- 18F-DCFPyL Positron Emission Tomography (PET)/Computed Tomography (CT) in Men With Prostate Cancer
- 5-Fluorouracil/Leucovorin (5FU/LV) in Combination With Regorafenib in Patients With Metastatic Colorectal Cancer
- 68Ga-NODAGA-RGD PET/ CT for Tumoral Neoangiogenesis
- 68Ga-NY104 PET/CT Guided Radiation Therapy in CcRCC.
- 68Ga-NYM096/177Lu-NYM096 in Metastatic ccRCC
- 68Ga-PSMA PET/CT in Prostate Cancer
- 68Ga-PSMA PET/CT in Prostate Cancer
- 68Ga-RM2 Compared to 68Ga-PSMA-617 PET/CT for Intermediate Risk Prostate Cancer Imaging
- 68Ga-RM2 Compared to 68Ga-PSMA-617 PET/CT for Prostate Cancer Imaging According to Various Metastatic Risks
- 89Zr-TLX250 for PET/CT Imaging of ccRCC - ZIRCON-CP Study

### Drugs (28)

- Aprutumab ixadotin Fibroblast growth factor receptor 2 binding agent
- Bemarituzumab Fibroblast growth factor receptor 2 inhibitor
- Brivanib Fibroblast growth factor receptor inhibitor
- Brivanib alaninate Fibroblast growth factor receptor inhibitor
- CP-459632 Fibroblast growth factor receptor inhibitor
- Derazantinib Fibroblast growth factor receptor inhibitor
- E-7090 Fibroblast growth factor receptor 2 inhibitor
- ENMD-981693 Fibroblast growth factor receptor inhibitor
- Erdafitinib Fibroblast growth factor receptor inhibitor
- Fexagratinib Fibroblast growth factor receptor inhibitor
- Fgfr inhibitor debio 1347 Fibroblast growth factor receptor 2 inhibitor
- Futibatinib Fibroblast growth factor receptor inhibitor
- HMPL-453 Fibroblast growth factor receptor 2 inhibitor
- Infigratinib Fibroblast growth factor receptor inhibitor
- [Infigratinib phosphate](https://trialight.com/data/asset/infigratinib-phosphate-0d4981cb-450a-4f7e-9abd-dd3fccddcea8.md) Fibroblast growth factor receptor inhibitor
- Lucitanib Fibroblast growth factor receptor 2 inhibitor
- LY-2874455 Fibroblast growth factor receptor inhibitor
- Nintedanib Fibroblast growth factor receptor inhibitor
- Nintedanib esylate Fibroblast growth factor receptor inhibitor
- Orantinib Fibroblast growth factor receptor inhibitor

---

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