FGFR2

ENSG00000066468
Target class
Kinase
Chromosome
10
Approved drugs
9
Clinical candidates (approved and in development)
27

Approved drugs
9
ClinGen gene-disease validity
Definitive
Clinical candidates (approved and in development)
27

Chemical probe available
Yes

Target name
FGFR2
Gene name
Fibroblast growth factor receptor 2
Gene symbol
FGFR2
Protein name
Fibroblast growth factor receptor 2 (FGFR-2) (EC 2.7.10.1) (K-sam) (KGFR) (Keratinocyte growth factor receptor) (CD antigen CD332)

  • CEK3
  • TK14
  • TK25
  • ECT1
  • K-SAM
  • CD332

  • KGFR
  • BEK
  • CFD1
  • JWS

Gene biotype
Protein coding
Gene family
Receptor tyrosine kinases|CD molecules|I-set domain containing
Target class
Kinase
Target type
Human gene

Tissues expressed in
47
Protein localisation evidence grade
Approved
Highest tissue expression
130.14
Tissue specificity (Gini)
0.485
Tissue specificity (tau)
0.886

KEGG gene identifiers
  • hsa:2263
Protein interaction confidence
0.852214
Protein interaction partners
103

  • R-HSA-2023837
  • R-HSA-2033519
  • R-HSA-5655253
  • R-HSA-8851708
  • R-HSA-8853333

End position
121598458
Start position
121478332
Chromosome
10
Strand
Reverse

Ensembl gene ID
ENSG00000066468
HGNC ID
HGNC:3689
www.genenames.org
NCBI Gene ID
2263
UniProt ID
P21802

  • Cell membrane
  • Single-pass type I membrane protein. Golgi apparatus. Cytoplasmic vesicle. Note=Detected on osteoblast plasma membrane lipid rafts. After ligand binding, the activated receptor is rapidly internalized and degraded.
  • SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane
  • Single-pass type I membrane protein. Note=After ligand binding, the activated receptor is rapidly internalized and degraded.
  • SUBCELLULAR LOCATION: [Isoform 3]: Cell membrane
  • Single-pass type I membrane protein. Note=After ligand binding, the activated receptor is rapidly internalized and degraded.
  • SUBCELLULAR LOCATION: [Isoform 8]: Secreted.
  • SUBCELLULAR LOCATION: [Isoform 13]: Secreted.
  • Cell Junctions
  • Nucleoplasm
  • Vesicles

Tissue specificity (tau)
0.885527
Expression inequality (Gini)
0.485194

Expression in transcripts per million

Brain - Spinal cord (cervical c-1)
130.14
Uterus
43.5
Skin - Sun Exposed (Lower leg)
41.01
Colon - Sigmoid
38.99
Skin - Not Sun Exposed (Suprapubic)
37.28

Expression in transcripts per million

  • Brain - Spinal cord (cervical c-1)130.14
  • Uterus43.5
  • Skin - Sun Exposed (Lower leg)41.01
  • Colon - Sigmoid38.99
  • Skin - Not Sun Exposed (Suprapubic)37.28
  • Brain - Substantia nigra33.68
  • Brain - Cerebellum31.42
  • Thyroid30.6
  • Brain - Putamen (basal ganglia)26.97
  • Minor Salivary Gland24.11
  • Cervix - Endocervix23.44
  • Brain - Hippocampus23.39
  • Brain - Caudate (basal ganglia)22.88
  • Vagina21.79
  • Brain - Cortex21.69
  • Esophagus - Muscularis21.6
  • Brain - Frontal Cortex (BA9)20.3
  • Brain - Amygdala19.54
  • Prostate19.52
  • Colon - Transverse17.74
  • Cervix - Ectocervix17.57
  • Bladder16.01
  • Brain - Nucleus accumbens (basal ganglia)15.95
  • Brain - Anterior cingulate cortex (BA24)15.94
  • Brain - Cerebellar Hemisphere15.68

And 29 more, listed on the interactive page.

Related records

Trials (887)

Drugs (28)