> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/target/fgfr1-4e918a87-4309-5610-93c5-066e5125172c
> Record changed: 2026-10-13

# FGFR1

ENSG00000077782

Target class

Kinase

Chromosome

8

Approved drugs

8

Clinical candidates (approved and in development)

26

## Clinical evidence

**Approved drugs**

8

**ClinGen gene-disease validity**

Definitive

**Clinical candidates (approved and in development)**

26

## Druggability

**Chemical probe available**

Yes

## Names

**Target name**

FGFR1

**Gene name**

Fibroblast growth factor receptor 1

**Gene symbol**

FGFR1

**Protein name**

Fibroblast growth factor receptor 1 (FGFR-1) (EC 2.7.10.1) (Basic fibroblast growth factor receptor 1) (BFGFR) (bFGF-R-1) (Fms-like tyrosine kinase 2) (FLT-2) (N-sam) (Proto-oncogene c-Fgr) (CD antigen CD331)

### Other names (9)

- H2
- H3
- H4
- H5
- CEK
- FLG
- BFGFR
- N-SAM
- CD331

### Previous gene symbols (2)

- FLT2
- KAL2

## Classification

**Gene biotype**

Protein coding

**Gene family**

Receptor tyrosine kinases|CD molecules|I-set domain containing

**Target class**

Kinase

**Target type**

Human gene

## Expression and localisation

**Tissues expressed in**

54

**Protein localisation evidence grade**

Approved

**Highest tissue expression**

144.82

**Tissue specificity (Gini)**

0.44

**Tissue specificity (tau)**

0.616

## Pathways and interactions

**KEGG gene identifiers**

- hsa:2260

**Protein interaction confidence**

0.870756

**Protein interaction partners**

123

### Reactome pathways (5)

- R-HSA-1839122
- R-HSA-5655302
- R-HSA-8853336
- R-HSA-9758919
- R-HSA-9793380

## Genomic location

**End position**

38468834

**Start position**

38400215

**Chromosome**

8

**Strand**

Reverse

## Identifiers

**Ensembl gene ID**

ENSG00000077782

**HGNC ID**

HGNC:3688

Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:3688)

**NCBI Gene ID**

2260

**UniProt ID**

P11362

## Cellular location

- Cell membrane
- Single-pass type I membrane protein. Nucleus. Cytoplasm, cytosol. Cytoplasmic vesicle. Note=After ligand binding, both receptor and ligand are rapidly internalized. Can translocate to the nucleus after internalization, or by translocation from the endoplasmic reticulum or Golgi apparatus to the cytosol, and from there to the nucleus.
- Basal body
- Centriolar satellite
- Cytokinetic bridge
- Cytosol
- Microtubules
- Mitotic spindle
- Primary cilium

## Tissue expression

**Tissue specificity (tau)**

0.615782

**Expression inequality (Gini)**

0.440342

### Highest expression

Expression in transcripts per million

**Artery - Aorta**

144.82

**Ovary**

142.88

**Artery - Tibial**

134.1

**Fallopian Tube**

122.27

**Brain - Cerebellar Hemisphere**

122

### All tissues (54)

Expression in transcripts per million

- Artery - Aorta144.82
- Ovary142.88
- Artery - Tibial134.1
- Fallopian Tube122.27
- Brain - Cerebellar Hemisphere122
- Brain - Cerebellum121.64
- Cervix - Ectocervix120.97
- Artery - Coronary117.8
- Uterus115.63
- Nerve - Tibial113.27
- Colon - Sigmoid111.09
- Esophagus - Gastroesophageal Junction109.98
- Esophagus - Muscularis107.35
- Adipose - Subcutaneous102.24
- Cervix - Endocervix98.23
- Breast - Mammary Tissue95.73
- Adipose - Visceral (Omentum)94.7
- Cells - Cultured fibroblasts92.84
- Bladder89.64
- Vagina77.75
- Pituitary69.72
- Prostate66.27
- Lung60.4
- Heart - Atrial Appendage49.81
- Thyroid45.85

And 29 more, listed on the interactive page.

## Biological functions

### Biological processes (22)

- GO:0000165  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0000165)
- GO:0001501  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0001501)
- GO:0001764  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0001764)
- GO:0001837  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0001837)
- GO:0008284  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008284)
- GO:0008543  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008543)
- GO:0010518  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0010518)
- GO:0016477  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016477)
- GO:0018108  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0018108)
- GO:0043009  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043009)
- GO:0043406  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043406)
- GO:0043410  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043410)
- GO:0043536  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043536)
- GO:0044344  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0044344)
- GO:0045595  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045595)
- GO:0045666  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045666)
- GO:0046777  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0046777)
- GO:0048015  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0048015)
- GO:0048705  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0048705)
- GO:0051897  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0051897)
- GO:1905564  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1905564)
- GO:2001028  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:2001028)

### Cellular components (2)

- GO:0005886  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886)
- GO:0043235  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043235)

### Molecular functions (8)

- GO:0004713  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004713)
- GO:0005007  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005007)
- GO:0005515  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515)
- GO:0008201  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008201)
- GO:0017134  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0017134)
- GO:0042802  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042802)
- GO:0042803  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042803)
- GO:0090722  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0090722)

## On-target safety

- dry eye  
### Effects

  - Inhibition/Decrease/Downregulation  
### Studies

  - clinical  
### Biological samples

  - ocular  
PubMed 38773351  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/38773351/)
- anaemia  
### Effects

  - Inhibition/Decrease/Downregulation  
### Studies

  - clinical  
### Biological samples

  - blood/bone marrow  
PubMed 38773351  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/38773351/)
- hypophosphataemia  
### Effects

  - Activation/Increase/Upregulation  
### Studies

  - clinical  
### Biological samples

  - metabolic  
PubMed 38773351  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/38773351/)
- keratitis  
### Effects

  - Inhibition/Decrease/Downregulation  
### Studies

  - clinical  
### Biological samples

  - ocular  
PubMed 38773351  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/38773351/)
- decreased platelet count  
### Effects

  - Inhibition/Decrease/Downregulation  
### Studies

  - clinical  
### Biological samples

  - blood/bone marrow  
PubMed 38773351  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/38773351/)
- weight loss  
### Effects

  - Activation/Increase/Upregulation  
### Studies

  - clinical  
### Biological samples

  - metabolic  
PubMed 38773351  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/38773351/)
- Hyperphosphataemia  
### Effects

  - Inhibition/Decrease/Downregulation  
### Studies

  - clinical  
### Biological samples

  - metabolism  
PubMed 38773351  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/38773351/)
- AST elevations  
### Effects

  - Inhibition/Decrease/Downregulation  
### Studies

  - clinical  
### Biological samples

  - liver  
PubMed 38773351  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/38773351/)
- decreased food intake  
### Effects

  - Activation/Increase/Upregulation  
### Studies

  - clinical  
### Biological samples

  - CNS  
PubMed 38773351  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/38773351/)
- reduced sweet taste  
### Effects

  - Activation/Increase/Upregulation  
### Studies

  - clinical  
PubMed 38773351  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/38773351/)
- fatigue  
### Effects

  - Inhibition/Decrease/Downregulation  
### Studies

  - clinical  
PubMed 38773351  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/38773351/)
- Hypoglycaemia  
### Effects

  - Activation/Increase/Upregulation  
### Studies

  - clinical  
### Biological samples

  - metabolic  
PubMed 38773351  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/38773351/)

## Off-target safety

- regulation of catalytic activity  
### Studies

  - biochemical: NVS\_ENZ\_hFGFR1, is one of one assay component(s) measured or calculated from the NVS\_ENZ\_hFGFR1 assay. It is designed to make measurements of enzyme activity, a form of enzyme reporter, as detected with fluorescence intensity signals by Fluorescence and electrophoretic mobility shift technology.  
### Biological samples

  - cell-free  
Evidence source  
Source: [www.epa.gov](https://www.epa.gov/chemical-research/exploring-toxcast-data-downloadable-data)

## Related records

### Trials (1,176)

- "Thymalfasin Immunotherapy Study with Triple Regimen in Advanced MSS/pMMR Colorectal Cancer"
- (VOYAGER) Study of Avapritinib vs Regorafenib in Patients With Locally Advanced Unresectable or Metastatic GIST
- \[18F\]FLT-PET as a Predictive Imaging Biomaker of Treatment Responses to Regorafenib
- \[18F\]Fluciclatide-PET, Pazopanib and Paclitaxel in Ovarian Cancer
- \[18F\]Fluoroestradiol-PET/CT Companion Imaging Study to the FORESEE Trial
- \[18F\]Fluoroestradiol-PET/CT Imaging of Invasive Lobular Carcinoma
- \[68 Ga\]-DOTANOC PET/CT in GEP-NETs
- \[68Ga\]Ga-FAPI-46 in Staging of Head and Neck Carcinomas
- \[68Ga\]Ga-PentixaFor PET/CT in Acute Myocardial Inflammation
- 11C-methionine in Diagnostics and Management of Glioblastoma Multiforme Patients (GlioMET)
- 12 Week Patient Study in Neovascular Age-related Macular Degeneration (AMD)
- 18F-DCFBC PET/CT in Prostate Cancer
- 18F-DCFPyL Positron Emission Tomography (PET)/Computed Tomography (CT) in Men With Prostate Cancer
- 5-Fluorouracil/Leucovorin (5FU/LV) in Combination With Regorafenib in Patients With Metastatic Colorectal Cancer
- 68Ga-NODAGA-RGD PET/ CT for Tumoral Neoangiogenesis
- 68Ga-NY104 PET/CT Guided Radiation Therapy in CcRCC.
- 68Ga-NYM096/177Lu-NYM096 in Metastatic ccRCC
- 68Ga-PSMA PET/CT in Prostate Cancer
- 68Ga-PSMA PET/CT in Prostate Cancer
- 68Ga-RM2 Compared to 68Ga-PSMA-617 PET/CT for Intermediate Risk Prostate Cancer Imaging

### Drugs (29)

- Brivanib Fibroblast growth factor receptor inhibitor
- Brivanib alaninate Fibroblast growth factor receptor inhibitor
- CP-459632 Fibroblast growth factor receptor inhibitor
- Derazantinib Fibroblast growth factor receptor inhibitor
- E-7090 Fibroblast growth factor receptor 1 inhibitor
- ENMD-981693 Fibroblast growth factor receptor inhibitor
- Erdafitinib Fibroblast growth factor receptor inhibitor
- Fexagratinib Fibroblast growth factor receptor inhibitor
- Fgfr inhibitor debio 1347 Fibroblast growth factor receptor 1 inhibitor
- Futibatinib Fibroblast growth factor receptor inhibitor
- HMPL-453 Fibroblast growth factor receptor 1 inhibitor
- Infigratinib Fibroblast growth factor receptor inhibitor
- [Infigratinib phosphate](https://trialight.com/data/asset/infigratinib-phosphate-0d4981cb-450a-4f7e-9abd-dd3fccddcea8.md) Fibroblast growth factor receptor inhibitor
- Lucitanib Fibroblast growth factor receptor 1 inhibitor
- LY-2874455 Fibroblast growth factor receptor inhibitor
- Nintedanib Fibroblast growth factor receptor inhibitor
- Nintedanib esylate Fibroblast growth factor receptor inhibitor
- Orantinib Fibroblast growth factor receptor inhibitor
- Pazopanib Fibroblast growth factor receptor 1 inhibitor
- Pazopanib hydrochloride Fibroblast growth factor receptor 1 inhibitor

---

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