FGFR1

ENSG00000077782
Target class
Kinase
Chromosome
8
Approved drugs
8
Clinical candidates (approved and in development)
26

Approved drugs
8
ClinGen gene-disease validity
Definitive
Clinical candidates (approved and in development)
26

Chemical probe available
Yes

Target name
FGFR1
Gene name
Fibroblast growth factor receptor 1
Gene symbol
FGFR1
Protein name
Fibroblast growth factor receptor 1 (FGFR-1) (EC 2.7.10.1) (Basic fibroblast growth factor receptor 1) (BFGFR) (bFGF-R-1) (Fms-like tyrosine kinase 2) (FLT-2) (N-sam) (Proto-oncogene c-Fgr) (CD antigen CD331)

  • H2
  • H3
  • H4
  • H5
  • CEK
  • FLG
  • BFGFR
  • N-SAM
  • CD331

  • FLT2
  • KAL2

Gene biotype
Protein coding
Gene family
Receptor tyrosine kinases|CD molecules|I-set domain containing
Target class
Kinase
Target type
Human gene

Tissues expressed in
54
Protein localisation evidence grade
Approved
Highest tissue expression
144.82
Tissue specificity (Gini)
0.44
Tissue specificity (tau)
0.616

KEGG gene identifiers
  • hsa:2260
Protein interaction confidence
0.870756
Protein interaction partners
123

  • R-HSA-1839122
  • R-HSA-5655302
  • R-HSA-8853336
  • R-HSA-9758919
  • R-HSA-9793380

End position
38468834
Start position
38400215
Chromosome
8
Strand
Reverse

Ensembl gene ID
ENSG00000077782
HGNC ID
HGNC:3688
www.genenames.org
NCBI Gene ID
2260
UniProt ID
P11362

  • Cell membrane
  • Single-pass type I membrane protein. Nucleus. Cytoplasm, cytosol. Cytoplasmic vesicle. Note=After ligand binding, both receptor and ligand are rapidly internalized. Can translocate to the nucleus after internalization, or by translocation from the endoplasmic reticulum or Golgi apparatus to the cytosol, and from there to the nucleus.
  • Basal body
  • Centriolar satellite
  • Cytokinetic bridge
  • Cytosol
  • Microtubules
  • Mitotic spindle
  • Primary cilium

Tissue specificity (tau)
0.615782
Expression inequality (Gini)
0.440342

Expression in transcripts per million

Artery - Aorta
144.82
Ovary
142.88
Artery - Tibial
134.1
Fallopian Tube
122.27
Brain - Cerebellar Hemisphere
122

Expression in transcripts per million

  • Artery - Aorta144.82
  • Ovary142.88
  • Artery - Tibial134.1
  • Fallopian Tube122.27
  • Brain - Cerebellar Hemisphere122
  • Brain - Cerebellum121.64
  • Cervix - Ectocervix120.97
  • Artery - Coronary117.8
  • Uterus115.63
  • Nerve - Tibial113.27
  • Colon - Sigmoid111.09
  • Esophagus - Gastroesophageal Junction109.98
  • Esophagus - Muscularis107.35
  • Adipose - Subcutaneous102.24
  • Cervix - Endocervix98.23
  • Breast - Mammary Tissue95.73
  • Adipose - Visceral (Omentum)94.7
  • Cells - Cultured fibroblasts92.84
  • Bladder89.64
  • Vagina77.75
  • Pituitary69.72
  • Prostate66.27
  • Lung60.4
  • Heart - Atrial Appendage49.81
  • Thyroid45.85

And 29 more, listed on the interactive page.

  • dry eye

    Effects

    • Inhibition/Decrease/Downregulation

    Studies

    • clinical

    Biological samples

    • ocular
    PubMed 38773351
    pubmed.ncbi.nlm.nih.gov

  • anaemia

    Effects

    • Inhibition/Decrease/Downregulation

    Studies

    • clinical

    Biological samples

    • blood/bone marrow
    PubMed 38773351
    pubmed.ncbi.nlm.nih.gov

  • hypophosphataemia

    Effects

    • Activation/Increase/Upregulation

    Studies

    • clinical

    Biological samples

    • metabolic
    PubMed 38773351
    pubmed.ncbi.nlm.nih.gov

  • keratitis

    Effects

    • Inhibition/Decrease/Downregulation

    Studies

    • clinical

    Biological samples

    • ocular
    PubMed 38773351
    pubmed.ncbi.nlm.nih.gov

  • decreased platelet count

    Effects

    • Inhibition/Decrease/Downregulation

    Studies

    • clinical

    Biological samples

    • blood/bone marrow
    PubMed 38773351
    pubmed.ncbi.nlm.nih.gov

  • weight loss

    Effects

    • Activation/Increase/Upregulation

    Studies

    • clinical

    Biological samples

    • metabolic
    PubMed 38773351
    pubmed.ncbi.nlm.nih.gov

  • Hyperphosphataemia

    Effects

    • Inhibition/Decrease/Downregulation

    Studies

    • clinical

    Biological samples

    • metabolism
    PubMed 38773351
    pubmed.ncbi.nlm.nih.gov

  • AST elevations

    Effects

    • Inhibition/Decrease/Downregulation

    Studies

    • clinical

    Biological samples

    • liver
    PubMed 38773351
    pubmed.ncbi.nlm.nih.gov

  • decreased food intake

    Effects

    • Activation/Increase/Upregulation

    Studies

    • clinical

    Biological samples

    • CNS
    PubMed 38773351
    pubmed.ncbi.nlm.nih.gov

  • reduced sweet taste

    Effects

    • Activation/Increase/Upregulation

    Studies

    • clinical
    PubMed 38773351
    pubmed.ncbi.nlm.nih.gov

  • fatigue

    Effects

    • Inhibition/Decrease/Downregulation

    Studies

    • clinical
    PubMed 38773351
    pubmed.ncbi.nlm.nih.gov

  • Hypoglycaemia

    Effects

    • Activation/Increase/Upregulation

    Studies

    • clinical

    Biological samples

    • metabolic
    PubMed 38773351
    pubmed.ncbi.nlm.nih.gov

  • regulation of catalytic activity

    Studies

    • biochemical: NVS_ENZ_hFGFR1, is one of one assay component(s) measured or calculated from the NVS_ENZ_hFGFR1 assay. It is designed to make measurements of enzyme activity, a form of enzyme reporter, as detected with fluorescence intensity signals by Fluorescence and electrophoretic mobility shift technology.

    Biological samples

    • cell-free
    Evidence source
    www.epa.gov

Related records

Trials (1,176)

Drugs (29)