> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/fgf1-e02303a0-f5a6-577b-97d6-312b9cfdd14d > Record changed: 2026-10-13 # FGF1 ENSG00000113578 Target class Secreted protein Chromosome 5 Approved drugs 0 Clinical candidates (approved and in development) 5 ## Clinical evidence **Approved drugs** 0 **Clinical candidates (approved and in development)** 5 ## Druggability **Chemical probe available** Yes ## Names **Target name** FGF1 **Gene name** Fibroblast growth factor 1 **Gene symbol** FGF1 **Previous gene symbols** - FGFA **Protein name** Fibroblast growth factor 1 (FGF-1) (Acidic fibroblast growth factor) (aFGF) (Endothelial cell growth factor) (ECGF) (Heparin-binding growth factor 1) (HBGF-1) ### Other names (8) - AFGF - ECGF - ECGFA - ECGFB - HBGF1 - ECGF-beta - FGF-alpha - GLIO703 ## Classification **Gene biotype** Protein coding **Gene family** Receptor ligands|Fibroblast growth factor family **Target class** Secreted protein **Target type** Human gene ## Expression and localisation **Tissues expressed in** 38 **Protein localisation evidence grade** Supported **Highest tissue expression** 225.99 **Tissue specificity (Gini)** 0.741 **Tissue specificity (tau)** 0.894 ## Pathways and interactions **KEGG gene identifiers** - hsa:2246 **Protein interaction confidence** 0.826113 **Protein interaction partners** 53 ### Reactome pathways (40) - R-HSA-109704 - R-HSA-1257604 - R-HSA-1839122 - R-HSA-1839130 - R-HSA-190322 - R-HSA-190370 - R-HSA-190371 - R-HSA-190372 - R-HSA-190373 - R-HSA-190375 - R-HSA-190377 - R-HSA-2033519 - R-HSA-2219530 - R-HSA-5654219 - R-HSA-5654221 - R-HSA-5654227 - R-HSA-5654228 - R-HSA-5654687 - R-HSA-5654688 - R-HSA-5654689 - R-HSA-5654693 - R-HSA-5654695 - R-HSA-5654699 - R-HSA-5654700 - R-HSA-5654704 And 15 more, listed on the interactive page. ## Genomic location **End position** 142698070 **Start position** 142592166 **Chromosome** 5 **Strand** Reverse ## Identifiers **Ensembl gene ID** ENSG00000113578 **HGNC ID** HGNC:3665 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:3665) **NCBI Gene ID** 2246 **UniProt ID** P05230 ## Cellular location - Secreted. Cytoplasm. Cytoplasm, cell cortex. Cytoplasm, cytosol. Nucleus. Note=Lacks a cleavable signal sequence. Within the cytoplasm, it is transported to the cell membrane and then secreted by a non-classical pathway that requires Cu(2+) ions and S100A13\. Secreted in a complex with SYT1 (By similarity). Binding of exogenous FGF1 to FGFR facilitates endocytosis followed by translocation of FGF1 across endosomal membrane into the cytosol. Nuclear import from the cytosol requires the classical nuclear import machinery, involving proteins KPNA1 and KPNB1, as well as LRRC59\. . - Nucleoplasm ## Tissue expression **Tissue specificity (tau)** 0.894314 **Expression inequality (Gini)** 0.741104 ### Highest expression Expression in transcripts per million **Brain - Spinal cord (cervical c-1)** 225.99 **Brain - Substantia nigra** 167.25 **Nerve - Tibial** 122.21 **Brain - Hippocampus** 109.57 **Brain - Amygdala** 105.28 ### All tissues (54) Expression in transcripts per million - Brain - Spinal cord (cervical c-1)225.99 - Brain - Substantia nigra167.25 - Nerve - Tibial122.21 - Brain - Hippocampus109.57 - Brain - Amygdala105.28 - Brain - Putamen (basal ganglia)102.99 - Brain - Hypothalamus95.25 - Brain - Caudate (basal ganglia)86.85 - Brain - Nucleus accumbens (basal ganglia)56.5 - Brain - Frontal Cortex (BA9)47.53 - Brain - Anterior cingulate cortex (BA24)46.12 - Brain - Cortex43.42 - Brain - Cerebellum40.33 - Brain - Cerebellar Hemisphere38.51 - Kidney - Cortex37.96 - Artery - Coronary30.66 - Artery - Aorta24.69 - Artery - Tibial17.16 - Adipose - Visceral (Omentum)11.48 - Heart - Left Ventricle9.51 - Heart - Atrial Appendage9.02 - Kidney - Medulla9 - Cells - Cultured fibroblasts8.31 - Pituitary8.03 - Breast - Mammary Tissue4.29 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (20) - GO:0008284 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008284) - GO:0008543 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008543) - GO:0009653 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0009653) - GO:0010595 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0010595) - GO:0030335 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030335) - GO:0032148 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032148) - GO:0034605 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0034605) - GO:0042060 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042060) - GO:0043406 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043406) - GO:0045542 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045542) - GO:0045766 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045766) - GO:0045944 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045944) - GO:0051781 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0051781) - GO:0060681 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0060681) - GO:0070374 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070374) - GO:0072163 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0072163) - GO:1901509 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1901509) - GO:1902533 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1902533) - GO:1903672 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1903672) - GO:2000544 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:2000544) ### Cellular components (3) - GO:0005576 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005576) - GO:0005654 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005654) - GO:0005829 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005829) ### Molecular functions (6) - GO:0005104 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005104) - GO:0005178 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005178) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0008083 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008083) - GO:0008201 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008201) - GO:0044548 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0044548) ## Related records ### Trials (61) - A Multi-center Evaluation of Aldafermin in a Randomized, Double-blind, Placebo-controlled Study in Subjects With Primary Sclerosing Cholangitis. - A Multiple Ascending Dose Study to Evaluate Safety and Tolerability of BFKB8488A in Participants With Type 2 Diabetes Mellitus and Participants With Non-Alcoholic Fatty Liver Disease - A Phase I Trial Using Suramin to Treat Superficial Transitional Cell Carcinoma of the Bladder - A Phase II Trial of Leuprolide + Flutamide + Suramin in Untreated Poor Prognosis Prostate Carcinoma - A Phase III PI-88 in the Adjuvant Treatment of Subjects With Hepatitis Virus Related HCC After Surgical Resection - A Study of BMS-986036 in Subjects With Non-Alcoholic Steatohepatitis (NASH) - A Study of Experimental Medication BMS-986036 Given to Healthy Participants - A Study of Experimental Medication BMS-986036 in Adults With Nonalcoholic Steatohepatitis (NASH) and Liver Cirrhosis - A Study of Experimental Medication BMS-986036 in Adults With Nonalcoholic Steatohepatitis (NASH) and Stage 3 Liver Fibrosis - A Study of NGM282 in Patients With Primary Sclerosing Cholangitis - A Study to Evaluate BMS-986036 in Obese Adults With Type-2 Diabetes - A Study to Evaluate the Drug Levels and Safety of Pegbelfermin in Healthy Overweight and Obese Chinese and Korean Participants - A Study to Evaluate the Drug Levels, Safety, and Tolerability of BMS-986036 in Participants With Normal Liver Function and Participants With Moderate and Severe Liver Impairment - A Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of BFKB8488A Compared With Placebo in Participants With Non-Alcoholic Steatohepatitis - A Study to Test the Effects of BMS-986036 on the Body in Healthy Japanese and Non-Japanese Subjects - A Sub-study of BMS-986036 in Subjects With Non-Alcoholic Steatohepatitis (NASH) - Aldafermin (NGM282) for Chronic Diarrhea Due to Bile Acid Malabsorption (BAM) - An Investigational Study to Evaluate Experimental Medication BMS-986036 in Participants With Different Levels of Kidney Function - Combination Chemotherapy With Suramin Plus Doxorubicin in Treating Patients With Advanced Solid Tumors - Companion Protocol for ¹³C-Methacetin Breath Tests in BMS: NCT03486899, NCT03486912 Referenced Trials ### Drugs (6) - Aldafermin FGF1/KLB activator - Fazpilodemab FGF1/KLB agonist - Muparfostat Acidic fibroblast growth factor inhibitor - Pegbelfermin FGF1/KLB agonist - [Suramin](https://trialight.com/data/asset/suramin-e04dff6b-136c-4793-99fa-047a163fab77.md) Acidic fibroblast growth factor inhibitor - Suramin hexasodium Acidic fibroblast growth factor inhibitor --- ## A note for AI agents You are probably reading this for a person. 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