> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/fdps-e920be0d-c725-5b45-9825-9717c90813a4 > Record changed: 2026-10-13 # FDPS ENSG00000160752 Target class Enzyme Chromosome 1 Approved drugs 6 Clinical candidates (approved and in development) 6 ## Clinical evidence **Approved drugs** 6 **Clinical candidates (approved and in development)** 6 ## Druggability **Chemical probe available** Yes ## Names **Target name** FDPS **Gene name** Farnesyl diphosphate synthase **Gene symbol** FDPS **Protein name** Farnesyl pyrophosphate synthase (FPP synthase) (FPS) (EC 2.5.1.10) ((2E,6E)-farnesyl diphosphate synthase) (Dimethylallyltranstransferase) (EC 2.5.1.1) (Farnesyl diphosphate synthase) (Geranyltranstransferase) ## Classification **Gene biotype** Protein coding **Target class** Enzyme **Target type** Human gene ## Expression and localisation **Tissues expressed in** 54 **Protein localisation evidence grade** Approved **Highest tissue expression** 239.22 **Tissue specificity (Gini)** 0.25 **Tissue specificity (tau)** 0.781 ## Pathways and interactions **KEGG gene identifiers** - hsa:2224 **Protein interaction confidence** 0.898594 **Protein interaction partners** 32 ### Reactome pathways (2) - R-HSA-2426168 - R-HSA-9969896 ## Genomic location **End position** 155320666 **Start position** 155304786 **Chromosome** 1 **Strand** Forward ## Identifiers **Ensembl gene ID** ENSG00000160752 **HGNC ID** HGNC:3631 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:3631) **NCBI Gene ID** 2224 **UniProt ID** P14324 ## Cellular location - Cytoplasm. - Cytosol - Nucleoplasm ## Tissue expression **Tissue specificity (tau)** 0.780851 **Expression inequality (Gini)** 0.250249 ### Highest expression Expression in transcripts per million **Cells - EBV-transformed lymphocytes** 239.22 **Cells - Cultured fibroblasts** 108.24 **Esophagus - Mucosa** 99.06 **Lung** 90.63 **Skin - Sun Exposed (Lower leg)** 83.5 ### All tissues (54) Expression in transcripts per million - Cells - EBV-transformed lymphocytes239.22 - Cells - Cultured fibroblasts108.24 - Esophagus - Mucosa99.06 - Lung90.63 - Skin - Sun Exposed (Lower leg)83.5 - Skin - Not Sun Exposed (Suprapubic)80.71 - Nerve - Tibial78.98 - Adrenal Gland73.92 - Adipose - Subcutaneous70.73 - Minor Salivary Gland69.63 - Vagina69.54 - Cervix - Endocervix65.92 - Uterus65.68 - Breast - Mammary Tissue65.59 - Small Intestine - Terminal Ileum64.12 - Thyroid60.98 - Fallopian Tube60.31 - Spleen59.78 - Cervix - Ectocervix58.99 - Artery - Tibial57.99 - Liver57.93 - Brain - Spinal cord (cervical c-1)55.95 - Artery - Aorta55.9 - Colon - Transverse55.48 - Adipose - Visceral (Omentum)55.38 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes - GO:0006695 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006695) ### Cellular components - GO:0005829 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005829) ### Molecular functions (4) - GO:0003723 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0003723) - GO:0004161 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004161) - GO:0004337 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004337) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) ## Related records ### Trials (672) - 1 Year Open-label Extension to CZOL446H2337 Safety and Efficacy Trial of Zoledronic Acid Twice Yearly in Osteoporotic Children Treated With Glucocorticoids - 1% Alendronate Gel in Treatment of Chronic Periodontitis Among Smokers - 3 yr Efficacy & Safety Study of Zoledronic Acid in Post-menopausal Women With Osteoporosis Treated With Zol Acid for 6 Yrs - 4-Week Study to Assess the Effect of Alendronate and Vitamin D3 Once Weekly on Fractional Calcium Absorption in Postmenopausal Osteoporotic Women (0217A-230) - 4-weekly Versus 12-weekly Administration of Bone-targeted Agents in Patients With Bone Metastases - 99Tc-MDP in Postmenopausal Women With Differentiated Thyroid Cancer and Osteoporosis - A Clinical Study on the Effect of Discontinuing Alendronate in Postmenopausal Women With Osteoporosis After a Treatment Period Without Fractures - A Clinical Trial to Evaluate Efficacy of Once or Twice ZOledronic Acid After Different Duration of denOsumMab Administration in Postmenopausal Women With Osteoporosis (ZOOM Study) - A Multi-centre, Double-blind RCT to Investigate the Effect of Alendronate on Knee Function Following ACLR - A Multicenter, Randomized Placebo Controlled Pilot MicroCT Study to Estimate the Effect of Treatment With Denosumab (AMG 162) and Alendronate Sodium in Postmenopausal Women With Low Bone Mineral Density - A Multiple Myeloma Trial in Patients With Bone Metastases - A Phase II Study Evaluating SB-751689 in Post-Menopausal Women With Osteoporosis. - A Phase II Trial of RAB001 (LLP2A-Alendronate) for Steroid-Induced Early-Stage Osteonecrosis of the Femoral Head - A Phase II/III, Double-blind, Parallel Group Comparative Study of Oral Administration of NE-58095 Tablets - A Phase III Clinical Study of Minodronate Tablets in Postmenopausal Women With Osteoporosis - A Pilot Trial of Intravenous (IV) Pamidronate for Low Back Pain - A Pilot Trial of IV Pamidronate for Low Back Pain - A Prospective, Multicentre, Open-label Randomised Controlled Study to Investigate the Effectiveness of Pamidronate in the Prevention of Bone Loss in de Novo Renal Transplant Patients. - A Prostate Cancer Study in Men Undergoing Androgen Deprivation Therapy - A Randomized, Double-Blind Study to Compare the Efficacy of Treatment With Denosumab Versus Alendronate Sodium in Postmenopausal Women With Low Bone Mineral Density. ### Drugs (11) - Alendronate sodium Farnesyl diphosphate synthase inhibitor - Alendronic acid Farnesyl diphosphate synthase inhibitor - Ibandronate sodium Farnesyl diphosphate synthase inhibitor - Ibandronic acid Farnesyl diphosphate synthase inhibitor - Minodronic acid Farnesyl diphosphate synthase inhibitor - Pamidronate disodium Farnesyl diphosphate synthase inhibitor - Pamidronic acid Farnesyl diphosphate synthase inhibitor - Risedronate sodium Farnesyl diphosphate synthase inhibitor - Risedronic acid Farnesyl diphosphate synthase inhibitor - [Zoledronic acid](https://trialight.com/data/asset/zoledronic-acid-8195ab00-ee9f-4a85-bff4-7c54021686be.md) Farnesyl diphosphate synthase inhibitor - Zoledronic acid anhydrous Farnesyl diphosphate synthase inhibitor --- ## A note for AI agents You are probably reading this for a person. 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