> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/fcgrt-ea6bf45e-e78e-56f3-b2bb-37ce2b94e334 > Record changed: 2026-11-04 # FCGRT ENSG00000104870 Target class Unclassified protein Chromosome 19 Approved drugs 2 Clinical candidates (approved and in development) 5 ## Clinical evidence **Approved drugs** 2 **Clinical candidates (approved and in development)** 5 ## Druggability **Chemical probe available** No ## Names **Target name** FCGRT **Gene name** Fc gamma receptor and transporter **Gene symbol** FCGRT **Protein name** IgG receptor FcRn large subunit p51 (FcRn) (IgG Fc fragment receptor transporter alpha chain) (Neonatal Fc receptor) ### Other names (2) - FcgammaRn - FcRn ## Classification **Gene biotype** Protein coding **Gene family** C1-set domain containing **Target class** Unclassified protein **Target type** Human gene ## Expression and localisation **Tissues expressed in** 54 **Highest tissue expression** 281.16 **Tissue specificity (Gini)** 0.446 **Tissue specificity (tau)** 0.682 ## Pathways and interactions **KEGG gene identifiers** - hsa:2217 **Protein interaction confidence** 0.8635 **Protein interaction partners** 10 ## Genomic location **End position** 49526917 **Start position** 49506806 **Chromosome** 19 **Strand** Forward ## Identifiers **Ensembl gene ID** ENSG00000104870 **HGNC ID** HGNC:3621 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:3621) **NCBI Gene ID** 2217 **UniProt ID** P55899 ## Cellular location - Cell membrane - Single-pass type I membrane protein . Endosome membrane . ### Publication evidence - PubMed 31104841 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/31104841/) ## Tissue expression **Tissue specificity (tau)** 0.681979 **Expression inequality (Gini)** 0.446325 ### Highest expression Expression in transcripts per million **Spleen** 281.16 **Cervix - Endocervix** 260.83 **Cervix - Ectocervix** 260.07 **Adipose - Subcutaneous** 207.39 **Adipose - Visceral (Omentum)** 206.86 ### All tissues (54) Expression in transcripts per million - Spleen281.16 - Cervix - Endocervix260.83 - Cervix - Ectocervix260.07 - Adipose - Subcutaneous207.39 - Adipose - Visceral (Omentum)206.86 - Ovary202.98 - Fallopian Tube192.1 - Lung184.96 - Nerve - Tibial180.25 - Breast - Mammary Tissue173.9 - Whole Blood171.56 - Small Intestine - Terminal Ileum169.47 - Uterus168.88 - Colon - Transverse142.5 - Artery - Coronary129.74 - Vagina124.38 - Thyroid121.48 - Liver111.59 - Bladder106.06 - Artery - Aorta105.36 - Prostate103.35 - Colon - Sigmoid100.46 - Esophagus - Gastroesophageal Junction95.59 - Skin - Sun Exposed (Lower leg)93.48 - Esophagus - Muscularis85.61 And 29 more, listed on the interactive page. ## Biological functions ### Cellular components - GO:0010008 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0010008) ### Molecular functions (2) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0019864 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0019864) ## Related records ### Trials (166) - A Clinical Study on the Efficacy and Safety of HBM9161 in Patients With ITP - A Long-term Study to Assess the Safety and Efficacy of Efgartigimod in Adult Patients With Primary Immune Thrombocytopenia (ITP). - A Non-interventional, Post-authorisation Safety Study of Patients Treated With Efgartigimod Alfa - A Phase 1 Bioequivalence Study of Efgartigimod PH20 SC Administered Via a Prefilled Syringe Versus a Vial+Syringe Presentation in Healthy Adults - A Phase 1 Study to Compare the Safety and Effect of Efgartigimod as an Intravenous Infusion With the Effect of Efgartigimod as a Subcutaneous Injection in Healthy Volunteers - A Phase 2/3 Study of Efgartigimod PH20 SC in Adult Participants With Bullous Pemphigoid - A Phase 3 Study to Evaluate the Efficacy and Safety of Efgartigimod IV in Patients With Acetylcholine Receptor Binding Antibody Seronegative Generalized Myasthenia Gravis - A Phase 3 Study to Evaluate the Long-term Safety, Tolerability and Efficacy of Efgartigimod PH20 SC in Adult Participants With Bullous Pemphigoid - A Phase 3 Study to Evaluate the Safety and Efficacy of Efgartigimod PH20 Subcutaneous in Adult Patients With Primary Immune Thrombocytopenia - A Phase 3, Open-label, Crossover Study to Evaluate Self-administration of Rozanolixizumab by Study Participants With Generalized Myasthenia Gravis (gMG) - A Phase I Study Evaluating the Safety, Tolerability, PK and PD in Healthy Chinese Volunteers - A Pilot Study of Efgartigimod for Immune-mediated Thrombotic Thrombocytopenic Purpura (iTTP) - A Proof-of-concept Study of the Efficacy and Safety of Nipocalimab in Participants With Active Rheumatoid Arthritis - A Proof-of-Concept Study to Assess Batoclimab in Participants With Graves' Disease - A Proof-of-concept Study to Evaluate the Efficacy and Safety of Rozanolixizumab to Treat Adult Study Participants With Severe Fibromyalgia Syndrome - A Research Study Looking Into How Ziltivekimab Works Compared to Placebo in Participants With Heart Failure and Inflammation - A Research Study of How the Medicine Ziltivekimab Works in the Body of Chinese Men and Women With Kidney Disease and Inflammation - [A Research Study to Look at How Ziltivekimab Works Compared to Placebo in People With Heart Failure and Inflammation](https://trialight.com/data/trial/a-research-study-to-look-at-how-ziltivekimab-works-compared-199a0302-7cc5-4376-b0dc-ca3c9666c83b.md) - A Research Study to Look at the Effect of Ziltivekimab on Plaque in the Blood Vessels of the Heart, Compared to Placebo, in People With a Heart Attack - A Safety and Dose-Finding Study of SYNT001 in Subjects With Pemphigus (Vulgaris or Foliaceus) ### Drugs (6) - Batoclimab IgG receptor FcRn large subunit p51 inhibitor - Efgartigimod alfa IgG receptor FcRn large subunit p51 antagonist - Nipocalimab IgG receptor FcRn large subunit p51 antagonist - Orilanolimab IgG receptor FcRn large subunit p51 antagonist - Rozanolixizumab IgG receptor FcRn large subunit p51 inhibitor - [Ziltivekimab](https://trialight.com/data/asset/ziltivekimab-cf6800e3-7dcc-441e-b882-bb8e9e8f278a.md) --- ## A note for AI agents You are probably reading this for a person. 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