> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/target/fasn-a51ba6dc-708b-551a-bb3f-ad691ef8840e
> Record changed: 2026-11-04

# FASN

ENSG00000169710

Target class

Enzyme

Chromosome

17

## Druggability

**Chemical probe available**

Yes

## Names

**Target name**

FASN

**Gene name**

Fatty acid synthase

**Gene symbol**

FASN

**Protein name**

Fatty acid synthase (EC 2.3.1.85) (Type I fatty acid synthase) \[Includes: \[Acyl-carrier-protein\] S-acetyltransferase (EC 2.3.1.38); \[Acyl-carrier-protein\] S-malonyltransferase (EC 2.3.1.39); 3-oxoacyl-\[acyl-carrier-protein\] synthase (EC 2.3.1.41); 3-oxoacyl-\[acyl-carrier-protein\] reductase (EC 1.1.1.100); 3-hydroxyacyl-\[acyl-carrier-protein\] dehydratase (EC 4.2.1.59); Enoyl-\[acyl-carrier-protein\] reductase (EC 1.3.1.39); Acyl-\[acyl-carrier-protein\] hydrolase (EC 3.1.2.14)\]

### Other names (2)

- FAS
- SDR27X1

## Classification

**Gene biotype**

Protein coding

**Gene family**

Short chain dehydrogenase/reductase superfamily|7BS orphan methyltransferases

**Target class**

Enzyme

**Target type**

Human gene

## Expression and localisation

**Tissues expressed in**

54

**Protein localisation evidence grade**

Enhanced

**Highest tissue expression**

374.98

**Tissue specificity (Gini)**

0.474

**Tissue specificity (tau)**

0.843

## Pathways and interactions

**KEGG gene identifiers**

- hsa:2194

**Protein interaction confidence**

0.830346

**Protein interaction partners**

78

### Reactome pathways (7)

- R-HSA-163765
- R-HSA-199220
- R-HSA-2426168
- R-HSA-75105
- R-HSA-9029558
- R-HSA-9918481
- R-HSA-9918487

## Genomic location

**End position**

82098294

**Start position**

82078338

**Chromosome**

17

**Strand**

Reverse

## Identifiers

**Ensembl gene ID**

ENSG00000169710

**HGNC ID**

HGNC:3594

Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:3594)

**NCBI Gene ID**

2194

**UniProt ID**

P49327

## Cellular location

- Cytoplasm . Melanosome . Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
- Cytosol
- Plasma membrane

### Publication evidence

- PubMed 17081065  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/17081065/)

## Tissue expression

**Tissue specificity (tau)**

0.843366

**Expression inequality (Gini)**

0.473718

### Highest expression

Expression in transcripts per million

**Adipose - Subcutaneous**

374.98

**Breast - Mammary Tissue**

291.74

**Adipose - Visceral (Omentum)**

290.36

**Brain - Cerebellum**

165.08

**Brain - Cerebellar Hemisphere**

131.02

### All tissues (54)

Expression in transcripts per million

- Adipose - Subcutaneous374.98
- Breast - Mammary Tissue291.74
- Adipose - Visceral (Omentum)290.36
- Brain - Cerebellum165.08
- Brain - Cerebellar Hemisphere131.02
- Skin - Not Sun Exposed (Suprapubic)127.21
- Skin - Sun Exposed (Lower leg)118.28
- Prostate103.18
- Pituitary99.08
- Esophagus - Mucosa96.77
- Cells - EBV-transformed lymphocytes86.74
- Liver81.47
- Nerve - Tibial80
- Cells - Cultured fibroblasts74.32
- Lung73.4
- Brain - Cortex70.04
- Stomach62.89
- Vagina59.35
- Minor Salivary Gland56.57
- Brain - Frontal Cortex (BA9)55.64
- Brain - Spinal cord (cervical c-1)48.79
- Bladder48.65
- Brain - Anterior cingulate cortex (BA24)46.19
- Artery - Coronary46.1
- Thyroid40.3

And 29 more, listed on the interactive page.

## Biological functions

### Biological processes (4)

- GO:0001649  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0001649)
- GO:0006631  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006631)
- GO:0044788  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0044788)
- GO:0046949  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0046949)

### Cellular components (5)

- GO:0005737  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005737)
- GO:0005829  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005829)
- GO:0005886  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886)
- GO:0016020  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016020)
- GO:0070062  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070062)

### Molecular functions (9)

- GO:0003723  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0003723)
- GO:0004312  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004312)
- GO:0004313  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004313)
- GO:0004315  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004315)
- GO:0004316  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004316)
- GO:0005515  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515)
- GO:0019171  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0019171)
- GO:0045296  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045296)
- GO:0141148  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0141148)

## On-target safety

- Increased, Liver Steatosis  
### Effects

  - Activation/Increase/Upregulation  
### Studies

  - cell-based  
Evidence source  
Source: [aopwiki.org](https://aopwiki.org/aops/58)
- N/A, Liver Steatosis  
### Effects

  - Activation/Increase/Upregulation  
### Studies

  - cell-based  
Evidence source  
Source: [aopwiki.org](https://aopwiki.org/aops/34)

## Off-target safety

- regulation of transcription factor activity  
### Studies (2)

  - cell-based: LTEA\_HepaRG\_FASNis one of 100 assay component(s) measured in the LTEA HepaRG cell culture assay. It is a marker of Steatosis.
  - cell-based: LTEA\_HepaRG\_FASNis one of 100 assay component(s) measured in the LTEA HepaRG cell culture assay. It is a marker of Steatosis.  
### Biological samples

  - HepaRG, cell line  
Evidence source  
Source: [www.epa.gov](https://www.epa.gov/chemical-research/exploring-toxcast-data-downloadable-data)

## Related records

### Trials (77)

- A Drug-Drug Interaction Study of Denifanstat and Resmetirom in Healthy Adult Participants
- A Low-Carbohydrate, Ketogenic Diet Versus Orlistat for Weight Loss
- A Phase 1, First-In-Human Study of Escalating Doses of Oral TVB-2640 in Patients With Solid Tumors
- A Phase 3 Study Evaluating the Safety and Efficacy of Denifanstat in Patients With MASH and F2/F3 Fibrosis
- A Phase 3 Study Evaluating the Safety and Efficacy of Denifanstat in Patients With MASLD and MASH
- A Phase I Pharmacokinetic Study of TVB-2640 (Denifanstat) in Subjects With Mild, Moderate, or Severe Hepatic Impairment Compared to Subjects With Normal Hepatic Function
- A Pilot Study of the Efficacy of Alli in the Management of Pre-operative Weight Loss Required for Bariatric Surgery.
- A Research Study Comparing Wegovy to Other Weight Management Drugs in People Living With Obesity in America
- A Study of Xenical (Orlistat) in Overweight and Obese Adolescents
- A Study to Assess the Pharmacologic Equivalence of Two Orlistat Dosage Forms
- A Study to Evaluate Safety of ASC40 Tablets in Patients With Moderate to Severe Acne Vulgaris
- A Study to Evaluate the Safety and Efficacy of ASC40 (Denifanstat) Tablets in the Treatment of Patients With Moderate to Severe Acne Vulgaris
- A Trial With EMP16 in Preparation for Late Phase Studies
- Adding Guided Self-Help Group Therapy to the Alli Weight Loss Program in Treating Binge Eating Disorder
- Aggressive Treatment of Metabolic Syndrome in Patients Receiving Clozapine for Schizophrenia
- An RCT of Metformin Vs Orlistat in Obese Anovulatory Women
- Anti-obesity Effects of Dandelion (Taraxacum Officinale L.)
- Ascending Single-dose Study to Evaluate TVB-2640 in Chinese Healthy Subjects
- Assess the Additional Weight Loss Effect of Orlistat Used in Combination With Sibutramine
- Combinatorial Therapy for Peristent Type 2 Diabetes After Gastric Banding

### Drugs (2)

- Denifanstat
- [Orlistat](https://trialight.com/data/asset/orlistat-efe96c73-de97-4970-9f8d-0c5633a8b660.md)

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