> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/faah-8bd94be5-4dfa-5292-b0c7-abc43b2d247f > Record changed: 2026-10-13 # FAAH ENSG00000117480 Target class Enzyme Chromosome 1 Approved drugs 1 Clinical candidates (approved and in development) 3 ## Clinical evidence **Approved drugs** 1 **Clinical candidates (approved and in development)** 3 ## Druggability **Chemical probe available** Yes ## Names **Target name** FAAH **Gene name** Fatty acid amide hydrolase **Gene symbol** FAAH **Protein name** Fatty-acid amide hydrolase 1 (EC 3.5.1.99) (Anandamide amidohydrolase 1) (Fatty acid ester hydrolase) (EC 3.1.1.-) (Oleamide hydrolase 1) ### Other names (2) - FAAH-1 - FAAH1 ## Classification **Gene biotype** Protein coding **Gene family** N-arachidonoylethanolamine hydrolases **Target class** Enzyme **Target type** Human gene ## Expression and localisation **Tissues expressed in** 54 **Protein localisation evidence grade** Approved **Highest tissue expression** 138.94 **Tissue specificity (Gini)** 0.432 **Tissue specificity (tau)** 0.797 ## Pathways and interactions **KEGG gene identifiers** - hsa:2166 **Reactome pathways** - R-HSA-2142753 **Protein interaction confidence** 0.84672 **Protein interaction partners** 25 ## Genomic location **End position** 46415754 **Start position** 46394265 **Chromosome** 1 **Strand** Forward ## Identifiers **Ensembl gene ID** ENSG00000117480 **HGNC ID** HGNC:3553 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:3553) **NCBI Gene ID** 2166 **UniProt ID** O00519 ## Cellular location - Endomembrane system - Single-pass membrane protein . Cytoplasm, cytoskeleton . Note=Seems to be attached to intracellular membranes and a portion of the cytoskeletal network. - Cytosol ### Publication evidence - PubMed 17015445 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/17015445/) ## Tissue expression **Tissue specificity (tau)** 0.79724 **Expression inequality (Gini)** 0.432177 ### Highest expression Expression in transcripts per million **Testis** 138.94 **Thyroid** 132.6 **Prostate** 114.35 **Brain - Cerebellum** 66.67 **Brain - Cerebellar Hemisphere** 63.57 ### All tissues (54) Expression in transcripts per million - Testis138.94 - Thyroid132.6 - Prostate114.35 - Brain - Cerebellum66.67 - Brain - Cerebellar Hemisphere63.57 - Brain - Spinal cord (cervical c-1)61.66 - Pituitary54.37 - Nerve - Tibial50.59 - Colon - Transverse40.77 - Brain - Nucleus accumbens (basal ganglia)40.54 - Minor Salivary Gland39.04 - Small Intestine - Terminal Ileum35.05 - Liver34.41 - Brain - Cortex34.13 - Kidney - Medulla33.24 - Stomach31.86 - Brain - Frontal Cortex (BA9)31.78 - Brain - Substantia nigra30.15 - Brain - Hypothalamus29.19 - Adrenal Gland29.1 - Kidney - Cortex28.91 - Brain - Hippocampus28.86 - Brain - Caudate (basal ganglia)28.44 - Breast - Mammary Tissue25.78 - Brain - Putamen (basal ganglia)25.42 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (2) - GO:0009062 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0009062) - GO:0019369 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0019369) ### Cellular components - GO:0005789 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005789) ### Molecular functions (2) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0017064 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0017064) ## Related records ### Trials (1,974) - "A Prospective Study of the Efficacy of Intracameral Dexamethasone (Dexycu™) Compared to Standard of Care Treatment for Post-Cataract Surgical Pain and Anterior Chamber Inflammation" - "Postoperative Pain Following Laser-Assisted Root Canal Treatment: A Randomized Clinical Trial" - 4-methylpyrazole and Acetaminophen Metabolism - 5 mg Glipizide/500 mg Metformin Hydrochloride Tablets, Fasting - 5 mg Glipizide/500 mg Metformin Hydrochloride Tablets, Non-Fasting - A 12-Week Efficacy Study of Paracetamol 1000mg Sustained-release Tablets in Patients With Osteoarthritis - A 3-Month Clinical Trial to Assess the Safety and Efficacy of the OZURDEX® Intraocular Implant in Patients With Diabetes Mellitus - A 5-treatment, Study in Healthy Volunteers to Assess The Safety, Tolerability, and Pharmacokinetics of Four Controlled Release (CR) Pregabalin Tablet Formulations and the Immediate Release (IR) Formulation Administered Fasted - A Bioequivalence (BE) Study Comparing The Commericializable And Clinical Formulations Of PF-00299804 - A Bioequivalence Study Between Two Brands of Medications to Treat Cough & Cold Symptoms - A Bioequivalence Study of a New Paracetamol Oral Suspension 24mg/ml Compared to the Marketed Paracetamol Oral Suspension (Panadol Baby and Infant 24mg/ml) in Healthy Adult Subjects - A Bioequivalence Study of CT-L01 Compared to Co-administration (ALO 12.5 mg and MET XR 500 mg) in Healthy Volunteers - A Bioequivalence Study of the Fixed Dose Combination Tablets of Canagliflozin and Metformin Extended Release (XR) With Respect to the Individual Components - A Bioequivalence Study of the Fixed Dose Combination Tablets of Canagliflozin and Metformin Extended Release (XR) With Respect to the Individual Components - A Bioequivalence Study of the Fixed Dose Combination Tablets of Canagliflozin and Metformin Extended Release (XR) With Respect to the Individual Components in Healthy Fed Participants - A Bioequivalence Study of the Fixed Dose Combination Tablets of Canagliflozin and Metformin Extended Release (XR) With Respect to the Individual Components in Healthy Fed Participants - A Bioequivalence Study of the Fixed Dose Combinations of Saxagliptin/Metformin XR Relative to Co-Administration - A Clinical Pharmacology Trial of Brexpiprazole Once-weekly (QW) Formulation Administered as Single and Multiple Oral Doses - A Clinical Study Intended To Compare Treatment With Voriconazole To Treatment With Amphotericin Followed By Fluconazole In Patients With Candidemia, A Serious Fungus Infection Of The Blood. - A Clinical Trial of MK-1045 in People With B-cell Acute Lymphoblastic Leukemia (MK-1045-005) ### Drugs (3) - [Acetaminophen](https://trialight.com/data/asset/acetaminophen-04ea33a5-49ee-4a1b-ad16-54627012140e.md) Anandamide amidohydrolase inhibitor - JNJ-42165279 Anandamide amidohydrolase inhibitor - Redafamdastat Anandamide amidohydrolase inhibitor --- ## A note for AI agents You are probably reading this for a person. 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