> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/f9-dcd29f16-ee70-5e32-84d3-e79dadee6285 > Record changed: 2026-10-13 # F9 ENSG00000101981 Target class Enzyme Chromosome X Approved drugs 9 Clinical candidates (approved and in development) 12 ## Clinical evidence **Approved drugs** 9 **ClinGen gene-disease validity** Definitive **Clinical candidates (approved and in development)** 12 ## Druggability **Chemical probe available** No ## Names **Other names** - FIX **Target name** F9 **Gene name** Coagulation factor IX **Gene symbol** F9 **Protein name** Coagulation factor IX (EC 3.4.21.22) (Christmas factor) (Plasma thromboplastin component) (PTC) \[Cleaved into: Coagulation factor IXa light chain; Coagulation factor IXa heavy chain\] ## Classification **Gene biotype** Protein coding **Gene family** Gla domain containing **Target class** Enzyme **Target type** Human gene ## Expression and localisation **Tissues expressed in** 1 **Highest tissue expression** 235.26 **Tissue specificity (Gini)** 0.981 **Tissue specificity (tau)** 1 ## Pathways and interactions **KEGG gene identifiers** - hsa:2158 **Protein interaction confidence** 0.855826 **Protein interaction partners** 23 ### Reactome pathways (14) - R-HSA-159740 - R-HSA-159763 - R-HSA-159782 - R-HSA-9629569 - R-HSA-9672383 - R-HSA-9672396 - R-HSA-9673202 - R-HSA-9673218 - R-HSA-9673221 - R-HSA-9673240 - R-HSA-9769735 - R-HSA-9769739 - R-HSA-9769743 - R-HSA-9935598 ## Genomic location **End position** 139563459 **Start position** 139530739 **Chromosome** X **Strand** Forward ## Identifiers **Ensembl gene ID** ENSG00000101981 **HGNC ID** HGNC:3551 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:3551) **NCBI Gene ID** 2158 **UniProt ID** P00740 ## Cellular location - Secreted . ### Publication evidence (5) - PubMed 19846852 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/19846852/) - PubMed 2592373 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/2592373/) - PubMed 3857619 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/3857619/) - PubMed 8295821 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/8295821/) - PubMed 9169594 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/9169594/) ## Tissue expression **Tissue specificity (tau)** 0.99999 **Expression inequality (Gini)** 0.981447 ### Highest expression Expression in transcripts per million **Liver** 235.26 **Testis** 0.07 **Cervix - Ectocervix** 0.04 **Spleen** 0.01 **Cervix - Endocervix** 0.01 ### All tissues (54) Expression in transcripts per million - Liver235.26 - Testis0.07 - Cervix - Ectocervix0.04 - Spleen0.01 - Cervix - Endocervix0.01 - Kidney - Medulla0 - Brain - Hypothalamus0 - Muscle - Skeletal0 - Skin - Sun Exposed (Lower leg)0 - Fallopian Tube0 - Heart - Left Ventricle0 - Prostate0 - Artery - Aorta0 - Colon - Sigmoid0 - Adrenal Gland0 - Brain - Caudate (basal ganglia)0 - Artery - Coronary0 - Small Intestine - Terminal Ileum0 - Brain - Nucleus accumbens (basal ganglia)0 - Brain - Substantia nigra0 - Heart - Atrial Appendage0 - Adipose - Subcutaneous0 - Cells - Cultured fibroblasts0 - Whole Blood0 - Brain - Anterior cingulate cortex (BA24)0 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (3) - GO:0006508 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006508) - GO:0007596 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007596) - GO:0031638 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0031638) ### Cellular components (6) - GO:0005576 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005576) - GO:0005788 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005788) - GO:0005796 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005796) - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) - GO:0031012 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0031012) - GO:0070062 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070062) ### Molecular functions (5) - GO:0004175 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004175) - GO:0004252 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004252) - GO:0005509 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005509) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0046872 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0046872) ## Related records ### Trials (1,260) - - 4th Visit at 17 Years of Cohort STANISLAS - Stanislas Ancillary Study ESCIF - "Circulating Fetal DNA, Pregnancy And Immune Diseases" - "Pregnancy and Viral Infections: Impact on Pregnant Women and Their Children. French Prospective Cohort" - 3TR (Taxonomy, Treatment, Targets and Remission) Systemic Lupus Erithematosus Study Protocol - 3TR (Taxonomy, Treatment, Targets and Remission) Systemic Lupus Erythematosus Study Protocol 2 - A 3D Hydrogel Model to Assess Endothelial Cell-macrophage Interactions in Simulated Microgravity (OR-DRPD-SRI2019) - A Clinical Study to Evaluate the Effects of NXT007 Compared to Emicizumab Prophylaxis in People With Hemophilia A - A Clinical Trial to Asses Efficacy and Safety of Cord Blood Eye Drops in Neurotrophic Keratopathy - A Clinical Trial to Evaluate Prophylactic Emicizumab Versus no Prophylaxis in Hemophilia A Participants Without Inhibitors - A DERMO-EPIDERMAL AUTOLOGOUS SKIN SUBSTITUTE FOR FURTHER THERAPEUTIC USE - A European Network for the Investigation of Gender Incongruence - A Gene Therapy Study for Hemophilia B - A Long Term Follow-up Study up to 4 Years After Study Vaccination to Assess Immunogenicity and Safety of the Investigational Vaccine in Adults - A Multicenter Access and Distribution Protocol for Unlicensed Cryopreserved Cord Blood Units (CBUs) - A Multicenter Phase 2 Single-arm Proof-of-concept Trial to Assess the Efficacy and Safety of Ustekinumab in Association With Prednisone for the Treatment of Non-infectious Severe Uveitis (NISU) - A Phase-I, Dose Escalation Study of Recombinant Human Interleukin-18 (Sb-485232) Combined With Adoptive Transfer of Vaccine-Primed CD3/CD28-Costimulated Autologous T-Cells Following Lymphodepletion for Adult Patients With Recurrent Ovarian, Fallopian Tube or Primary Peritoneal Cancer - A Prospective, Mono-center, Interventional Study Evaluating the Effect of One Year Initial Care by Hygieno-dietary Advices With or Without Phlebotomy on Glycemia After at Least 5 Years in Patients With Dysmetabolic Iron Overload Syndrome - A Randomized Control Trial to Evaluate the Efficacy of Autologous Blood Injection Versus Local Corticosteroid Injection for Treatment of Lateral Epicondylitis - A Randomized, Multi-center, Open-label, Paired Controlled, Crossover In Vivo Study - A Research Study Investigating Nonacog Beta Pegol (N9-GP) for Treatment and Prevention of Bleedings in Chinese People With Haemophilia B ### Drugs (12) - Albutrepenonacog alfa Coagulation factor IX exogenous protein - Coagulation factor IX human Coagulation factor IX exogenous protein - Coagulation factor IX recombinant human Coagulation factor IX exogenous protein - Eftrenonacog alfa Coagulation factor IX exogenous protein - Emicizumab Coagulation factor IX and X other - Etranacogene dezaparvovec Coagulation factor IX exogenous protein - Fidanacogene elaparvovec Coagulation factor IX exogenous gene - Nonacog beta pegol Coagulation factor IX exogenous protein - Pegnivacogin Coagulation factor IX inhibitor - [Prothrombin complex concentrate](https://trialight.com/data/asset/prothrombin-complex-concentrate-1ab4acb5-4b09-4890-a175-8f8ed7d4f12b.md) Coagulation factor IX exogenous protein - Trenonacog alfa Coagulation factor IX exogenous protein - Valoctocogene roxaparvovec Coagulation factor IX exogenous protein --- ## A note for AI agents You are probably reading this for a person. 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