> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/f8-1ef36c20-6bf4-556d-a4a6-84a2b9a0039a > Record changed: 2026-10-13 # F8 ENSG00000185010 Target class Secreted protein Chromosome X Approved drugs 13 Clinical candidates (approved and in development) 16 ## Clinical evidence **Approved drugs** 13 **ClinGen gene-disease validity** Definitive **Clinical candidates (approved and in development)** 16 ## Druggability **Chemical probe available** No ## Names **Target name** F8 **Gene name** Coagulation factor VIII **Gene symbol** F8 **Previous gene symbols** - F8C **Protein name** Coagulation factor VIII (Antihemophilic factor) (AHF) (Procoagulant component) \[Cleaved into: Factor VIIIa heavy chain, 200 kDa isoform; Factor VIIIa heavy chain, 92 kDa isoform; Factor VIII B chain; Factor VIIIa light chain\] ### Other names (3) - FVIII - DXS1253E - HEMA ## Classification **Gene biotype** Protein coding **Gene family** Multicopper oxidase family **Target class** Secreted protein **Target type** Human gene ## Expression and localisation **Tissues expressed in** 53 **Highest tissue expression** 19.65 **Tissue specificity (Gini)** 0.395 **Tissue specificity (tau)** 0.728 ## Pathways and interactions **KEGG gene identifiers** - hsa:2157 **Protein interaction confidence** 0.882704 **Protein interaction partners** 27 ### Reactome pathways (16) - R-HSA-114608 - R-HSA-163841 - R-HSA-204005 - R-HSA-5694530 - R-HSA-9672383 - R-HSA-9672387 - R-HSA-9672391 - R-HSA-9672393 - R-HSA-9672395 - R-HSA-9672396 - R-HSA-9672397 - R-HSA-9673202 - R-HSA-9674519 - R-HSA-9769735 - R-HSA-9769739 - R-HSA-9769743 ## Genomic location **End position** 155026940 **Start position** 154835788 **Chromosome** X **Strand** Reverse ## Identifiers **Ensembl gene ID** ENSG00000185010 **HGNC ID** HGNC:3546 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:3546) **NCBI Gene ID** 2157 **UniProt ID** P00451 ## Cellular location - Secreted, extracellular space. ## Tissue expression **Tissue specificity (tau)** 0.728408 **Expression inequality (Gini)** 0.394591 ### Highest expression Expression in transcripts per million **Adipose - Visceral (Omentum)** 19.65 **Adipose - Subcutaneous** 15.74 **Heart - Atrial Appendage** 13.51 **Breast - Mammary Tissue** 12.64 **Ovary** 12.57 ### All tissues (54) Expression in transcripts per million - Adipose - Visceral (Omentum)19.65 - Adipose - Subcutaneous15.74 - Heart - Atrial Appendage13.51 - Breast - Mammary Tissue12.64 - Ovary12.57 - Uterus11.53 - Heart - Left Ventricle10.76 - Spleen10.65 - Thyroid9.73 - Esophagus - Muscularis9.42 - Lung8.93 - Artery - Coronary8.83 - Nerve - Tibial8.72 - Cervix - Endocervix8.13 - Esophagus - Gastroesophageal Junction7.96 - Adrenal Gland7.8 - Fallopian Tube7.67 - Colon - Sigmoid6.73 - Muscle - Skeletal6.27 - Prostate6.11 - Bladder5.83 - Brain - Frontal Cortex (BA9)5.59 - Testis4.97 - Kidney - Cortex4.72 - Pituitary4.32 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes - GO:0007596 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007596) ### Cellular components (7) - GO:0005576 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005576) - GO:0005788 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005788) - GO:0005796 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005796) - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) - GO:0030134 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030134) - GO:0031093 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0031093) - GO:0033116 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0033116) ### Molecular functions - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) ## Related records ### Trials (519) - "LANK-2": Activated and Expanded NK Cell Immunotherapy Together With Salvage Chemotherapy in Children, Adolescents and Young Adults With Relapsed or Refractary Acute Leukemia - 5-MTHF Supplementation for Treatment of Type 1 Diabetes Patients - A 12-Week Study of Topical Pirenzepine or Placebo in Type 2 Diabetic Patients (T2DM) With Painful Peripheral Neuropathy - A 48-Month Study to Evaluate Long-Term Effectiveness of Elocta on Joint Health - A Bioequivalence Study Between Two Brands of Medications to Treat Cough & Cold Symptoms - A Clinical Double Blind, Randomized Study of the Efficacy of Hyperuricemia Treatment With Anserine Product. - A Clinical Study on the Improvement of Sleep Quality, Skin Condition and Life Status After Taking Sleep Aid Drinks - A Clinical Study to Evaluate the Effects of NXT007 Compared to Factor VIII Prophylaxis in Participants With Hemophilia A - A Clinical Trial to Evaluate Prophylactic Emicizumab Versus no Prophylaxis in Hemophilia A Participants Without Inhibitors - A Long-term Study of ADYNOVI/ADYNOVATE in Participants With Haemophilia A - A Multi-centre, Comparative, Double Blind, Randomised Cross-over Trial Investigating Single Dose Pharmacokinetics and Safety of Turoctocog Alfa Pegol From the Pivotal Process and Turoctocog Alfa Pegol From the Commercial Process in Patients With Severe Haemophilia A - A Multicenter Study to Evaluate Safety and Immunogenicity of a Live-attenuated Chikungunya Vaccine in Adolescents - A Multinational, Open-Label, Non-Controlled Trial on Safety, Efficacy and Pharmacokinetics of NNC 0129-0000-1003 in Previously Treated Paediatric Patients With Severe Haemophilia A - A Paroxetine- and Placebo-Controlled Study of 50 mg/Day and 100 mg/Day of EB-1010 Among Outpatients With Major Depressive Disorder Who Have Responded Inadequately to Prior Selective Serotonin Reuptake Inhibitors (SSRIs) and Serotonin Norepinephrine Reuptake Inhibitors (SNRIs) - A Phase 3 Open-label Interventional Study of Intravenous Recombinant Coagulation Factor VIII Fc-von Willebrand Factor-XTEN Fusion Protein, Efanesoctocog Alfa (BIVV001), in Patients With Severe Hemophilia A - A Phase I Study of Monoclonal Antibody TB-402 in Healthy Male Volunteers - A Phase II Study With Low-dose Recombinant Human IL-2 for the Treatment of Primary Sjögren's Syndrome - A Pilot Crossover Trial of Prophylactic Wilate Compared to Placebo for Heavy Menstrual Bleeding in Patients with VWD - A Pilot Study of Activated T Cell Therapy for Refractory/Relapsed Neuroblastoma - A Pilot-Study With Low-dose hrIL-2 for the Treatment of Systemic Lupus Erythematosus ### Drugs (16) - Antihemophilic factor, pegylated (MW 20000) human sequence recombinant Coagulation factor VIII exogenous protein - Damoctocog alfa pegol Coagulation factor VIII exogenous protein - [Drotrecogin alfa (activated)](https://trialight.com/data/asset/drotrecogin-alfa-activated-0dceffea-aa6c-43cb-a437-9126961a621e.md) Coagulation factor VIII inhibitor - Efanesoctocog alfa Coagulation factor VIII exogenous protein - Efmoroctocog alfa Coagulation factor VIII exogenous protein - Giroctocogene fitelparvovec Coagulation factor VIII exogenous gene - Human coagulation factor VIII Coagulation factor VIII exogenous protein - Lonoctocog alfa Coagulation factor VIII exogenous protein - Moroctocog alfa Coagulation factor VIII exogenous protein - Octocog alfa Coagulation factor VIII exogenous protein - Omfiloctocog alfa Coagulation factor VIII exogenous protein - Simoctocog alfa Coagulation factor VIII exogenous protein - Susoctocog alfa Coagulation factor VIII exogenous protein - TB-402 Coagulation factor VIII inhibitor - Turoctocog alfa Coagulation factor VIII exogenous protein - Turoctocog alfa pegol Coagulation factor VIII exogenous protein --- ## A note for AI agents You are probably reading this for a person. 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