> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/f7-8dcfa027-dee9-53eb-bed1-e74fed8b6b67 > Record changed: 2026-10-13 # F7 ENSG00000057593 Target class Enzyme Chromosome 13 Approved drugs 3 Clinical candidates (approved and in development) 6 ## Clinical evidence **Approved drugs** 3 **ClinGen gene-disease validity** Definitive **Clinical candidates (approved and in development)** 6 ## Druggability **Chemical probe available** Yes ## Names **Target name** F7 **Gene name** Coagulation factor VII **Gene symbol** F7 **Protein name** Coagulation factor VII (EC 3.4.21.21) (Proconvertin) (Serum prothrombin conversion accelerator) (SPCA) (Eptacog alfa) \[Cleaved into: Factor VII light chain; Factor VII heavy chain\] ## Classification **Gene biotype** Protein coding **Gene family** Gla domain containing **Target class** Enzyme **Target type** Human gene ## Expression and localisation **Tissues expressed in** 8 **Highest tissue expression** 83.64 **Tissue specificity (Gini)** 0.878 **Tissue specificity (tau)** 0.994 ## Pathways and interactions **KEGG gene identifiers** - hsa:2155 **Protein interaction confidence** 0.844345 **Protein interaction partners** 29 ### Reactome pathways (6) - R-HSA-1368108 - R-HSA-159740 - R-HSA-159763 - R-HSA-159782 - R-HSA-9769735 - R-HSA-9769739 ## Genomic location **End position** 113120685 **Start position** 113105762 **Chromosome** 13 **Strand** Forward ## Identifiers **Ensembl gene ID** ENSG00000057593 **HGNC ID** HGNC:3544 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:3544) **NCBI Gene ID** 2155 **UniProt ID** P08709 ## Cellular location - Secreted . ### Publication evidence - PubMed 36951360 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/36951360/) ## Tissue expression **Tissue specificity (tau)** 0.994338 **Expression inequality (Gini)** 0.878303 ### Highest expression Expression in transcripts per million **Liver** 83.64 **Testis** 3.25 **Cervix - Ectocervix** 1.94 **Brain - Cerebellum** 1.58 **Brain - Frontal Cortex (BA9)** 1.51 ### All tissues (54) Expression in transcripts per million - Liver83.64 - Testis3.25 - Cervix - Ectocervix1.94 - Brain - Cerebellum1.58 - Brain - Frontal Cortex (BA9)1.51 - Cervix - Endocervix1.46 - Brain - Cortex1.36 - Brain - Cerebellar Hemisphere1.13 - Brain - Anterior cingulate cortex (BA24)0.87 - Vagina0.74 - Pituitary0.72 - Ovary0.69 - Fallopian Tube0.66 - Brain - Hypothalamus0.59 - Brain - Nucleus accumbens (basal ganglia)0.56 - Prostate0.54 - Skin - Sun Exposed (Lower leg)0.52 - Small Intestine - Terminal Ileum0.49 - Brain - Caudate (basal ganglia)0.45 - Skin - Not Sun Exposed (Suprapubic)0.43 - Minor Salivary Gland0.39 - Kidney - Medulla0.38 - Brain - Putamen (basal ganglia)0.38 - Kidney - Cortex0.32 - Breast - Mammary Tissue0.31 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (7) - GO:0002690 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0002690) - GO:0007596 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007596) - GO:0010641 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0010641) - GO:0016485 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016485) - GO:0030335 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030335) - GO:0032008 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032008) - GO:0050927 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0050927) ### Cellular components (6) - GO:0005576 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005576) - GO:0005788 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005788) - GO:0005796 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005796) - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) - GO:0031012 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0031012) - GO:1905286 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1905286) ### Molecular functions (3) - GO:0004252 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004252) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0008236 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008236) ## Related records ### Trials (142) - "Salvage Use" of Recombinant Factor VIIa After Inadequate Haemostasis in Complex Cardiac Surgery - "Spot Sign" Selection of Intracerebral Hemorrhage to Guide Hemostatic Therapy - A Comparison Study of Bypassing Agent Therapy With and Without Tranexamic Acid in Haemophilia A Patients With Inhibitor - A Long-term Assessment of Physical Activity, Range of Motion, and Functional Status Following Elective Orthopedic Surgery in Hemophilia Patients With Inhibitors - A Phase 2/ 3 Trial to Evaluate the Efficacy and Safety of BAY86-6150 - A Research Study to See How Safe is Eptacog Alfa When Used to Stop Heavy Bleeding in Women After Giving Birth in India - A Single Dose Trial Investigating Safety and Local Tolerability of Ascending Doses of Long Acting Activated Recombinant Human Factor VII in Healthy Male Volunteers - A Study to Assess the Effects of 2 Different Prothrombin Complex Concentrates on the Pharmacodynamics of Rivaroxaban in Healthy Adult Volunteers - A Study to Assess the Effects of 2 Prothrombin Complex Concentrates on the Pharmacodynamics of Apixaban in Healthy Adult Subjects - A Study to Assess the Independent Effects of 4-Factor Prothrombin Complex Concentrate and Tranexamic Acid on Bleeding/Pharmacodynamics in Healthy Participants - A Study to Assess the Reversal of the Anticoagulant Effects of Milvexian by 4-Factor Prothrombin Complex Concentrate (4F-PCC) (Part 1) and Recombinant Human Factor VIIa (rFVIIa) (Part 2) in Healthy Participants - A Study to Evaluate Safety and Efficacy of NovoSeven® in Patients With Glanzmann's Thrombasthenia in Japan - A Study to Evaluate Safety, Tolerability, Pharmacokinetics, Immunogenicity, and Pharmacodynamics of JNJ-64179375 in Healthy Male Subjects - A Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of Prophylactic Emicizumab Versus no Prophylaxis in Hemophilia A Participants With Inhibitors - A Trial Evaluating the Efficacy and Safety of Prophylactic Administration of Concizumab in Haemophilia A and B Patients With Inhibitors - A Trial Investigating the Pharmacokinetics and Pharmacodynamics of rFVIIa in Patients With Haemophilia A or B With or Without Inhibitors - A Two-part Study in Edoxaban-treated Healthy Subjects to Establish a Punch Biopsy Bleeding Model and to Evaluate the Effect of a 4-factor Prothrombin Complex Concentrate on Anticoagulation - Activated Recombinant Human Factor VII Following Cardiac Bypass Surgery for Paediatric Congenital Heart Disease - Activated Recombinant Human Factor VII in Patients With Dengue Haemorrhagic Fever - Activated Recombinant Human Factor VII in Pelvic-acetabular Fracture Reconstruction ### Drugs (6) - Coagulation factor VII human Coagulation factor VII exogenous protein - Eptacog alfa (activated) Coagulation factor VII exogenous protein - Eptacog alfa pegol (activated) Coagulation factor VII exogenous protein - Eptacog beta (activated) Coagulation factor VII exogenous protein - PCI-27483 Coagulation factor VII inhibitor - [Prothrombin complex concentrate](https://trialight.com/data/asset/prothrombin-complex-concentrate-1ab4acb5-4b09-4890-a175-8f8ed7d4f12b.md) Coagulation factor VII exogenous protein --- ## A note for AI agents You are probably reading this for a person. 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