> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/target/f2-fc5eec4d-526b-53e3-9646-7a8d42969d92
> Record changed: 2026-10-13

# F2

ENSG00000180210

Target class

Enzyme

Chromosome

11

Approved drugs

8

Clinical candidates (approved and in development)

13

## Clinical evidence

**Approved drugs**

8

**ClinGen gene-disease validity**

Definitive

**Clinical candidates (approved and in development)**

13

## Druggability

**Chemical probe available**

Yes

## Names

**Target name**

F2

**Gene name**

Coagulation factor II, thrombin

**Gene symbol**

F2

**Protein name**

Prothrombin (EC 3.4.21.5) (Coagulation factor II) \[Cleaved into: Activation peptide fragment 1; Activation peptide fragment 2; Thrombin light chain; Thrombin heavy chain\]

## Classification

**Gene biotype**

Protein coding

**Gene family**

Receptor ligands|Gla domain containing|Complement system regulators and receptors|Kringle domain containing

**Target class**

Enzyme

**Target type**

Human gene

## Expression and localisation

**Tissues expressed in**

4

**Highest tissue expression**

599.63

**Tissue specificity (Gini)**

0.974

**Tissue specificity (tau)**

1

## Pathways and interactions

**KEGG gene identifiers**

- hsa:2147

**Protein interaction confidence**

0.878727

**Protein interaction partners**

88

### Reactome pathways (17)

- R-HSA-159740
- R-HSA-159763
- R-HSA-159782
- R-HSA-202733
- R-HSA-375276
- R-HSA-381426
- R-HSA-416476
- R-HSA-456926
- R-HSA-76009
- R-HSA-9657688
- R-HSA-9672391
- R-HSA-9769733
- R-HSA-9769735
- R-HSA-9769739
- R-HSA-9769743
- R-HSA-977606
- R-HSA-9918481

## Genomic location

**End position**

46739822

**Start position**

46719166

**Chromosome**

11

**Strand**

Forward

## Identifiers

**Ensembl gene ID**

ENSG00000180210

**HGNC ID**

HGNC:3535

Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:3535)

**NCBI Gene ID**

2147

**UniProt ID**

P00734

## Cellular location

- Secreted, extracellular space.

## Tissue expression

**Tissue specificity (tau)**

0.99966

**Expression inequality (Gini)**

0.974355

### Highest expression

Expression in transcripts per million

**Liver**

599.63

**Brain - Cerebellar Hemisphere**

1.7

**Brain - Cerebellum**

1.64

**Testis**

1.39

**Artery - Tibial**

0.56

### All tissues (54)

Expression in transcripts per million

- Liver599.63
- Brain - Cerebellar Hemisphere1.7
- Brain - Cerebellum1.64
- Testis1.39
- Artery - Tibial0.56
- Colon - Sigmoid0.42
- Stomach0.36
- Artery - Coronary0.26
- Bladder0.23
- Esophagus - Gastroesophageal Junction0.22
- Esophagus - Muscularis0.22
- Brain - Nucleus accumbens (basal ganglia)0.2
- Ovary0.19
- Artery - Aorta0.18
- Colon - Transverse0.18
- Cervix - Ectocervix0.18
- Brain - Hypothalamus0.18
- Prostate0.16
- Pituitary0.16
- Brain - Caudate (basal ganglia)0.16
- Uterus0.14
- Brain - Putamen (basal ganglia)0.12
- Fallopian Tube0.12
- Brain - Cortex0.11
- Brain - Frontal Cortex (BA9)0.1

And 29 more, listed on the interactive page.

## Biological functions

### Biological processes (23)

- GO:0006508  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006508)
- GO:0007166  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007166)
- GO:0007596  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007596)
- GO:0009611  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0009611)
- GO:0010544  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0010544)
- GO:0030168  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030168)
- GO:0030193  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030193)
- GO:0030194  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030194)
- GO:0030195  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030195)
- GO:0032967  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032967)
- GO:0042730  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042730)
- GO:0045861  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045861)
- GO:0048712  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0048712)
- GO:0051281  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0051281)
- GO:0051480  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0051480)
- GO:0051918  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0051918)
- GO:0061844  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0061844)
- GO:0070493  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070493)
- GO:0070945  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070945)
- GO:1900016  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1900016)
- GO:1900182  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1900182)
- GO:1900738  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1900738)
- GO:2000379  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:2000379)

### Cellular components (8)

- GO:0005576  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005576)
- GO:0005788  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005788)
- GO:0005796  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005796)
- GO:0005886  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886)
- GO:0009897  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0009897)
- GO:0031012  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0031012)
- GO:0070062  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070062)
- GO:0072562  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0072562)

### Molecular functions (8)

- GO:0001530  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0001530)
- GO:0004252  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004252)
- GO:0005102  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005102)
- GO:0005515  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515)
- GO:0008083  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008083)
- GO:0008201  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008201)
- GO:0048018  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0048018)
- GO:0070053  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070053)

## On-target safety

- Impaired recruitment , Population trajectory  
### Studies

  - cell-based  
Evidence source  
Source: [aopwiki.org](https://aopwiki.org/aops/187)
- hemorrhagic events  
### Effects

  - Inhibition/Decrease/Downregulation: general  
### Studies

  - clinical: hemorrhagic events  
### Biological samples

  - cardiovascular system  
Evidence source  
Source: [doi.org](https://doi.org/10.1002/9781118098141.ch2)

## Related records

### Trials (445)

- A Clinical Study of KW-3357 in Patients With DIC
- A Clinical Study to Evaluate the Pharmacokinetics of Microdose Midazolam, Dabigatran, Pitavastatin, Atorvastatin and Rosuvastatin in Healthy Volunteers and Renal Impairment Patients
- A Clinical Trial Comparing Efficacy and Safety of Dabigatran Etexilate With Warfarin in Patients With Cerebral Venous and Dural Sinus Thrombosis (RE-SPECT CVT)
- A Comparative Sudy Comparing Argatroban® IV vs Desirudin SC for Suspected HIT With or Without Thrombosis Syndrome
- A Dose Response Study of Dabigatran Etexilate(BIBR 1048) in Pharmacodynamics and Safety in Patients With Non-valvular Atrial Fibrillation in Comparison to Warfarin
- A Drug Drug Interaction (DDI) Study of Selpercatinib and Dabigatran in Healthy Participants
- A Drug-drug Interaction Study of Lanabecestat (LY3314814) in Healthy Participants
- A Drug-Drug Interaction Study to Estimate the Effect of PF-07081532 on the Pharmacokinetics of Dabigatran and Rosuvastatin in Overweight or Obese Adult Participants
- A First Time in Human Study to Assess GSK2336805 in Healthy Volunteers and Single Doses in Chronically Infected Hepatitis C Patients.
- A Nationwide Observational Study Looking at Effectiveness and Bleeding Complications of NOACs vs. VKA in Non-valvular Atrial Fibrillation Patients.
- A Novel Therapeutic Target for Alzheimer's Disease in Men and Women 50-85 Years of Age.
- A Pharmacokinetic Interaction Study Between Odalasvir, Given as a Single Agent or in Combination With Simeprevir, and Dabigatran Etexilate Mesylate in Healthy Participants
- A Phase 3 Clinical Study of KW-3357 in Patients With DIC
- A Phase I Study of the Co-administration of VLX-1005 and Argatroban in Healthy Human Subjects
- A Prospective, Open Label Study Evaluating Two Management Strategies on Gastrointestinal Symptoms in Patients Newly on Treatment With Pradaxa for the Prevention of Stroke and Systemic Embolism With Non-valvular Atrial Fibrillation
- A Real-World Comparison of Safety and Effectiveness of Novel Oral Anti-Coagulant (NOAC) Naïve and Warfarin Naïve Non-Valvular Atrial Fibrillation (NVAF) Patients With Medicare Advantage Coverage
- A Single Center Diagnostic, Cross-sectional Study of Coronary Microvascular Dysfunction
- A Single Dose Bioequivalence Study of WD-1602 Versus Pradaxa® in Healthy Subjects Under Fed Condition
- A Study in Europe Based on Medical Records That Looks at the Safety of Dabigatran in Children Below 2 Years of Age Who Have Had a Blood Clot and Are at Risk of Developing Another Blood Clot
- A Study in Healthy Male Participants to Compare How CHF10196 Affects How the Body Absorbs and Processes Two Commonly Used Medicines: Dabigatran, a Blood Thinner, and Rosuvastatin, a Medicine Used to Lower Cholesterol

### Drugs (14)

- Antithrombin alfa Thrombin inhibitor
- Argatroban Thrombin inhibitor
- Atecegatran metoxil Thrombin inhibitor
- Bivalirudin Thrombin inhibitor
- Dabigatran Thrombin inhibitor
- Dabigatran etexilate Thrombin inhibitor
- Dabigatran etexilate mesylate Thrombin inhibitor
- Defibrotide Thrombin antagonist
- Desirudin Thrombin inhibitor
- Ichorcumab Thrombin inhibitor
- Lepirudin Thrombin inhibitor
- Prothrombin Thrombin exogenous protein
- [Prothrombin complex concentrate](https://trialight.com/data/asset/prothrombin-complex-concentrate-1ab4acb5-4b09-4890-a175-8f8ed7d4f12b.md) Thrombin exogenous protein
- Ximelagatran Thrombin inhibitor

---

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