> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/f11-ee6a0377-9fea-5dd3-a409-ae140fbedce5 > Record changed: 2026-10-13 # F11 ENSG00000088926 Target class Enzyme Chromosome 4 Approved drugs 1 Clinical candidates (approved and in development) 4 ## Clinical evidence **Approved drugs** 1 **ClinGen gene-disease validity** Definitive **Clinical candidates (approved and in development)** 4 ## Druggability **Chemical probe available** Yes ## Names **Other names** - FXI **Target name** F11 **Gene name** Coagulation factor XI **Gene symbol** F11 **Protein name** Coagulation factor XI (FXI) (EC 3.4.21.27) (Plasma thromboplastin antecedent) (PTA) \[Cleaved into: Coagulation factor XIa heavy chain; Coagulation factor XIa light chain\] ## Classification **Gene biotype** Protein coding **Target class** Enzyme **Target type** Human gene ## Expression and localisation **Tissues expressed in** 4 **Protein localisation evidence grade** Approved **Highest tissue expression** 59.96 **Tissue specificity (Gini)** 0.944 **Tissue specificity (tau)** 0.992 ## Pathways and interactions **KEGG gene identifiers** - hsa:2160 **Protein interaction confidence** 0.824 **Protein interaction partners** 21 ### Reactome pathways (4) - R-HSA-9673221 - R-HSA-9769739 - R-HSA-9769743 - R-HSA-9935598 ## Genomic location **End position** 186291273 **Start position** 186260159 **Chromosome** 4 **Strand** Forward ## Identifiers **Ensembl gene ID** ENSG00000088926 **HGNC ID** HGNC:3529 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:3529) **NCBI Gene ID** 2160 **UniProt ID** P03951 ## Cellular location - Secreted. - Vesicles ## Tissue expression **Tissue specificity (tau)** 0.991721 **Expression inequality (Gini)** 0.943972 ### Highest expression Expression in transcripts per million **Liver** 59.96 **Pancreas** 12.01 **Kidney - Medulla** 8.1 **Kidney - Cortex** 2.42 **Lung** 0.99 ### All tissues (54) Expression in transcripts per million - Liver59.96 - Pancreas12.01 - Kidney - Medulla8.1 - Kidney - Cortex2.42 - Lung0.99 - Small Intestine - Terminal Ileum0.44 - Pituitary0.15 - Cervix - Endocervix0.14 - Testis0.11 - Artery - Tibial0.11 - Stomach0.1 - Nerve - Tibial0.1 - Brain - Cerebellum0.1 - Brain - Cortex0.08 - Ovary0.08 - Colon - Sigmoid0.08 - Brain - Cerebellar Hemisphere0.08 - Artery - Aorta0.07 - Artery - Coronary0.07 - Fallopian Tube0.06 - Brain - Caudate (basal ganglia)0.06 - Colon - Transverse0.06 - Brain - Nucleus accumbens (basal ganglia)0.06 - Brain - Putamen (basal ganglia)0.06 - Brain - Anterior cingulate cortex (BA24)0.05 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (3) - GO:0007596 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007596) - GO:0031639 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0031639) - GO:0051919 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0051919) ### Cellular components (3) - GO:0005576 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005576) - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) - GO:0070062 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070062) ### Molecular functions (2) - GO:0004252 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004252) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) ## Related records ### Trials (81) - A Multicenter Study to Evaluate the Efficacy and Safety of Cinryze® for the Treatment of Acute Antibody-mediated Rejection in Participants With Kidney Transplant - A Pilot Study to Evaluate the Use of C1 Esterase Inhibitor (Human) in Patients With Acute Antibody-Mediated Rejection - [A Study Comparing Abelacimab to Apixaban in the Treatment of Cancer-associated VTE](https://trialight.com/data/trial/a-study-comparing-abelacimab-to-apixaban-in-the-treatment-of-465e7ec0-ac7e-441d-a154-29f9b38c113a.md) - A Study Comparing Abelacimab to Dalteparin in the Treatment of Gastrointestinal/Genitourinary Cancer and Associated VTE - A Study Evaluating Drug Drug Interaction Between Milvexian and Atorvastatin in Healthy Participants - A Study of JNJ-70033093 (BMS-986177) in Healthy Adult Participants - A Study of JNJ-70033093 (BMS-986177) in Healthy Chinese Adult Participants - A Study of JNJ-70033093 (BMS-986177) Versus Subcutaneous Enoxaparin in Participants Undergoing Elective Total Knee Replacement Surgery - A Study of JNJ-70033093 (Milvexian) in Healthy Adult Participants - A Study of JNJ-70033093 and Digoxin in Healthy Participants - A Study of JNJ-70033093 in Healthy Participants - A Study of Milvexian in Healthy Adult Females - [A Study of Milvexian in Participants After a Recent Acute Coronary Syndrome](https://trialight.com/data/trial/a-study-of-milvexian-in-participants-after-a-recent-acute-0b485d43-2b27-4d92-b8a0-1716a132b945.md) - [A Study of Milvexian in Participants After an Acute Ischemic Stroke or High-Risk Transient Ischemic Attack- LIBREXIA-STROKE](https://trialight.com/data/trial/a-study-of-milvexian-in-participants-after-an-acute-ischemic-ef73fb8c-7882-4291-a1aa-bb4cc7f9d2a3.md) - A Study of Milvexian Using an IV Microtracer With Additional Formulation and Food Effect Comparison in Healthy Participants - [A Study of Milvexian Versus Apixaban in Participants With Atrial Fibrillation](https://trialight.com/data/trial/a-study-of-milvexian-versus-apixaban-in-participants-with-e26ab0d2-647d-49a6-bf8b-cc799e52b193.md) - A Study on BMS-986177 for the Prevention of a Stroke in Patients Receiving Aspirin and Clopidogrel - A Study to Assess Administration of an Oral Anti-thrombotic With Antiplatelet Therapy in Healthy Subjects - A Study to Assess the Reversal of the Anticoagulant Effects of Milvexian by 4-Factor Prothrombin Complex Concentrate (4F-PCC) (Part 1) and Recombinant Human Factor VIIa (rFVIIa) (Part 2) in Healthy Participants - A Study to Evaluate Safety of Single Doses of BMS-986177 in Patients With End Stage Renal Disease (ESRD) Treated With Hemodialysis ### Drugs (4) - [Abelacimab](https://trialight.com/data/asset/abelacimab-d62f1002-e47d-46c4-b7b4-807b74b3a1f1.md) Coagulation factor XI inhibitor - Human C1-esterase inhibitor Coagulation factor XI inhibitor - [Milvexian](https://trialight.com/data/asset/milvexian-339c16a0-10d4-46bb-9570-47b9050a80b1.md) Coagulation factor XI inhibitor - Osocimab Coagulation factor XI negative allosteric modulator --- ## A note for AI agents You are probably reading this for a person. 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