> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/f10-170c83e1-bc3d-524d-b28c-6b5a17d00cb8 > Record changed: 2026-10-13 # F10 ENSG00000126218 Target class Enzyme Chromosome 13 Approved drugs 7 Clinical candidates (approved and in development) 14 ## Clinical evidence **Approved drugs** 7 **ClinGen gene-disease validity** Definitive **Clinical candidates (approved and in development)** 14 ## Druggability **Chemical probe available** No ## Names **Other names** - fX **Target name** F10 **Gene name** Coagulation factor X **Gene symbol** F10 **Protein name** Coagulation factor X (EC 3.4.21.6) (Stuart factor) (Stuart-Prower factor) \[Cleaved into: Factor X light chain; Factor X heavy chain; Activated factor Xa heavy chain\] ## Classification **Gene biotype** Protein coding **Gene family** Gla domain containing **Target class** Enzyme **Target type** Human gene ## Expression and localisation **Tissues expressed in** 45 **Highest tissue expression** 75.53 **Tissue specificity (Gini)** 0.591 **Tissue specificity (tau)** 0.851 ## Pathways and interactions **KEGG gene identifiers** - hsa:2159 **Protein interaction confidence** 0.847419 **Protein interaction partners** 31 ### Reactome pathways (9) - R-HSA-159740 - R-HSA-159763 - R-HSA-159782 - R-HSA-9672383 - R-HSA-9672396 - R-HSA-9673202 - R-HSA-9769735 - R-HSA-9769739 - R-HSA-9769743 ## Genomic location **End position** 113149531 **Start position** 113122788 **Chromosome** 13 **Strand** Forward ## Identifiers **Ensembl gene ID** ENSG00000126218 **HGNC ID** HGNC:3528 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:3528) **NCBI Gene ID** 2159 **UniProt ID** P00742 ## Cellular location - Secreted. ## Tissue expression **Tissue specificity (tau)** 0.850685 **Expression inequality (Gini)** 0.591147 ### Highest expression Expression in transcripts per million **Cervix - Ectocervix** 75.53 **Liver** 73.38 **Cervix - Endocervix** 45.32 **Ovary** 39.47 **Vagina** 30.55 ### All tissues (54) Expression in transcripts per million - Cervix - Ectocervix75.53 - Liver73.38 - Cervix - Endocervix45.32 - Ovary39.47 - Vagina30.55 - Fallopian Tube29.79 - Adipose - Subcutaneous24.53 - Heart - Atrial Appendage23.45 - Skin - Sun Exposed (Lower leg)21.52 - Uterus20.81 - Lung19.98 - Artery - Aorta17.66 - Artery - Coronary17.6 - Bladder16.46 - Nerve - Tibial16.17 - Testis15.8 - Artery - Tibial14.98 - Prostate13.66 - Adipose - Visceral (Omentum)13.33 - Skin - Not Sun Exposed (Suprapubic)13.14 - Breast - Mammary Tissue12.86 - Esophagus - Gastroesophageal Junction12.75 - Cells - Cultured fibroblasts11.73 - Thyroid10.82 - Small Intestine - Terminal Ileum8.24 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (3) - GO:0007596 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007596) - GO:0030335 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030335) - GO:0032008 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032008) ### Cellular components (5) - GO:0005576 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005576) - GO:0005788 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005788) - GO:0005796 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005796) - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) - GO:0009897 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0009897) ### Molecular functions (3) - GO:0004252 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004252) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0005543 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005543) ## Related records ### Trials (979) - A Bioequivalence Study to Compare the Pharmacokinetics of Two Betrixaban Formulations - A Clinical Study of KW-3357 in Patients With DIC - A Clinical Study to Evaluate the Effects of NXT007 Compared to Emicizumab Prophylaxis in People With Hemophilia A - A Clinical Study to Evaluate the Safety and Pharmacokinetics of CKD-344 - A Clinical Study to Evaluate the Safety and Pharmacokinetics of CKD-344 in Healthy Volunteers - A Clinical Trial to Evaluate Prophylactic Emicizumab Versus no Prophylaxis in Hemophilia A Participants Without Inhibitors - A Clinical Trial to Evaluate the Effect of Grapefruit Juice on the PK/PD of Edoxaban - A Healthy Volunteer Pharmacokinetics (PK)/Pharmacodynamics (PD), Safety and Tolerability Study of Andexanet in Healthy Japanese and Caucasian Subjects - A Healthy Volunteer PK/PD, Safety and Tolerability Study of Andexanet After Betrixaban Dosing - A Healthy Volunteer PK/PD, Safety and Tolerability Study of Second Generation Andexanet Alfa - A Healthy Volunteer Trial to Gain Information About the Blood Concentrations of PF-06412562 After Oral Administration of a Modified Release Formulation in Fasted and Fed Conditions - A Human Phase I Absolute Bioavailability Study of PRT054021 in Healthy Male Volunteers - A Multi-center Study of Apixaban(APPROACH) - A Nationwide Observational Study Looking at Effectiveness and Bleeding Complications of NOACs vs. VKA in Non-valvular Atrial Fibrillation Patients. - A New Oral Treatment For Type II Diabetes Mellitus - A Non-interventional Study on Xarelto for Treatment of Venous Thromboembolism (VTE) and Prevention of Recurrent VTE in Patients With Active Cancer - A Pharmacokinetic Study to Investigate the Effect of Food on the Pharmacokinetics of YM150 - A Pharmacokinetic Study to Investigate the Effect of Food on the Pharmacokinetics of YM150 Tablet - A Pharmacokinetics, Pharmacodynamics and Safety Study of Single Dose of Rivaroxaban in Participants With End-Stage Renal Disease (ESRD) on Maintenance Hemodialysis - A Phase 2 Pilot Study of Apixaban for the Prevention of Thromboembolic Events in Patients With Advanced (Metastatic) Cancer ### Drugs (16) - Antithrombin alfa Coagulation factor X inhibitor - [Apixaban](https://trialight.com/data/asset/apixaban-9e91f03a-6eac-4da8-9f08-88d740399be5.md) Coagulation factor X inhibitor - Bemiparin Coagulation factor X inhibitor - Betrixaban Coagulation factor X inhibitor - Coagulation factor X human Coagulation factor X exogenous protein - Darexaban Coagulation factor X inhibitor - Edoxaban Coagulation factor X inhibitor - Edoxaban tosylate Coagulation factor X inhibitor - Emicizumab Coagulation factor IX and X other - Idrabiotaparinux sodium Coagulation factor X inhibitor - Idraparinux Coagulation factor X inhibitor - Idraparinux sodium Coagulation factor X inhibitor - Letaxaban Coagulation factor X inhibitor - Otamixaban Coagulation factor X inhibitor - [Prothrombin complex concentrate](https://trialight.com/data/asset/prothrombin-complex-concentrate-1ab4acb5-4b09-4890-a175-8f8ed7d4f12b.md) Coagulation factor X exogenous protein - [Rivaroxaban](https://trialight.com/data/asset/rivaroxaban-3f354e10-6d35-4989-9e00-318be65808fb.md) Coagulation factor X inhibitor --- ## A note for AI agents You are probably reading this for a person. 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