> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/ezh2-dc548072-a5e7-5671-9127-b9d88c1e8640 > Record changed: 2026-11-04 # EZH2 ENSG00000106462 Target class Epigenetic regulator Chromosome 7 Approved drugs 1 Clinical candidates (approved and in development) 2 ## Clinical evidence **Approved drugs** 1 **ClinGen gene-disease validity** Definitive **Clinical candidates (approved and in development)** 2 ## Druggability **Chemical probe available** Yes ## Names **Target name** EZH2 **Gene name** Enhancer of zeste 2 polycomb repressive complex 2 subunit **Gene symbol** EZH2 **Protein name** Histone-lysine N-methyltransferase EZH2 (EC 2.1.1.356) (ENX-1) (Enhancer of zeste homolog 2) (Lysine N-methyltransferase 6) ### Other names (4) - EZH1 - ENX-1 - KMT6 - KMT6A ## Classification **Gene biotype** Protein coding **Gene family** Histone lysine methyltransferases|Myb/SANT domain containing|Polycomb repressive complex 2|SET domain containing **Target class** Epigenetic regulator **Target type** Human gene ## Expression and localisation **Tissues expressed in** 44 **Protein localisation evidence grade** Enhanced **Highest tissue expression** 54.7 **Tissue specificity (Gini)** 0.598 **Tissue specificity (tau)** 0.914 ## Pathways and interactions **KEGG gene identifiers** - hsa:2146 **Protein interaction confidence** 0.866306 **Protein interaction partners** 209 ### Reactome pathways (10) - R-HSA-212300 - R-HSA-2559580 - R-HSA-3214841 - R-HSA-5617472 - R-HSA-8943724 - R-HSA-8953750 - R-HSA-9609690 - R-HSA-9710421 - R-HSA-9764725 - R-HSA-9909649 ## Genomic location **End position** 148884330 **Start position** 148807257 **Chromosome** 7 **Strand** Reverse ## Identifiers **Ensembl gene ID** ENSG00000106462 **HGNC ID** HGNC:3527 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:3527) **NCBI Gene ID** 2146 **UniProt ID** Q15910 ## Cellular location - Nucleus . Note=Localizes to the inactive X chromosome in trophoblast stem cells. . - Nucleoplasm ### Publication evidence (4) - PubMed 12101246 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/12101246/) - PubMed 14532106 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/14532106/) - PubMed 15231737 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/15231737/) - PubMed 9584199 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/9584199/) ## Tissue expression **Tissue specificity (tau)** 0.914249 **Expression inequality (Gini)** 0.598321 ### Highest expression Expression in transcripts per million **Cells - EBV-transformed lymphocytes** 54.7 **Testis** 41.42 **Esophagus - Mucosa** 16.03 **Skin - Not Sun Exposed (Suprapubic)** 14.82 **Skin - Sun Exposed (Lower leg)** 14.69 ### All tissues (54) Expression in transcripts per million - Cells - EBV-transformed lymphocytes54.7 - Testis41.42 - Esophagus - Mucosa16.03 - Skin - Not Sun Exposed (Suprapubic)14.82 - Skin - Sun Exposed (Lower leg)14.69 - Cells - Cultured fibroblasts12.15 - Spleen9.41 - Vagina9.17 - Small Intestine - Terminal Ileum9.09 - Brain - Cerebellar Hemisphere7.75 - Brain - Cerebellum7.44 - Colon - Transverse6.83 - Lung6.63 - Ovary5.53 - Cervix - Endocervix5.09 - Cervix - Ectocervix5.04 - Minor Salivary Gland4.85 - Nerve - Tibial4.44 - Uterus4.09 - Breast - Mammary Tissue3.86 - Adipose - Subcutaneous3.56 - Fallopian Tube3.36 - Stomach3.33 - Prostate3.32 - Kidney - Medulla3.32 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (17) - GO:0000122 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0000122) - GO:0006325 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006325) - GO:0006355 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006355) - GO:0008284 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008284) - GO:0010718 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0010718) - GO:0030335 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030335) - GO:0031048 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0031048) - GO:0031507 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0031507) - GO:0031509 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0031509) - GO:0042752 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042752) - GO:0043406 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043406) - GO:0043547 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043547) - GO:0045814 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045814) - GO:0045892 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045892) - GO:0048387 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0048387) - GO:0071902 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0071902) - GO:1902808 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1902808) ### Cellular components (7) - GO:0000781 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0000781) - GO:0000785 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0000785) - GO:0000792 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0000792) - GO:0005634 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005634) - GO:0005654 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005654) - GO:0005694 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005694) - GO:0035098 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0035098) ### Molecular functions (13) - GO:0001222 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0001222) - GO:0003682 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0003682) - GO:0003723 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0003723) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0016279 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016279) - GO:0031490 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0031490) - GO:0031491 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0031491) - GO:0042054 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042054) - GO:0042393 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042393) - GO:0046976 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0046976) - GO:0140938 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0140938) - GO:0140951 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0140951) - GO:1990841 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1990841) ## Related records ### Trials (124) - A Clinical Study of SHR-4394 in Combination With Anti-tumor Therapy in Prostate Cancer - A Clinical Study on the Efficacy and Safety of Zeprumetostat in Relapsed/Refractory Large Granular Lymphocyte Leukemia - A Feasibility Trial of Tazemetostat Plus CAR T Cell Therapy in B-cell Lymphomas - A Food Effect Study of SHR2554 on Healthy Chinese Male Adult Subjects - A Itraconazole Effect Study of SHR2554 on Healthy Chinese Adult Subjects - A Phase 1 Study of SHR2554 in Subjects With Relapsed or Refractory Mature Lymphoid Neoplasms - A Phase 1/2, Open-label Study of Valemetostat in Combination With Rituximab and Lenalidomide in Relapsed or Refractory Follicular Lymphoma - A Phase II Study of SHR2554 in Patients With Relapsed or Refractory Follicular Lymphoma - A Prospective Clinical Study of Zeprumetosta in Patients With Relapsed or Refractory Cutaneous T-Cell Lymphoma - A Relative Bioavailability Study of Different Processes of SHR2554 Tablets in Healthy Adult Subjects - A Rifampin Effect Study of SHR2554 on Healthy Chinese Adult Subjects - A Safety and Pharmacology Study of Atezolizumab (MPDL3280A) Administered With Obinutuzumab or Tazemetostat in Participants With Relapsed/Refractory Follicular Lymphoma and Diffuse Large B-cell Lymphoma - A Safety and Preliminary Efficacy Study of CC-99282, Alone and in Combination With Anti-lymphoma Agents in Participants With Relapsed or Refractory Non-Hodgkin Lymphomas (R/R NHL) - A Study Evaluating CPI-1205 in Patients With B-Cell Lymphomas - A Study of HRS-5041 Tablets Combined With Antitumor Therapy in Subjects With Advanced Prostate Cancer - A Study of Mevrometostat for Treatment of Relapsed/Refractory SCLC, Castration Resistant Prostate Cancer, and Follicular Lymphoma - A Study of Mevrometostat With Enzalutamide in People With Prostate Cancer Who Have Previously Received Androgen Receptor Pathway Inhibitor Therapy - A Study of SHR2554 Alone or in Combination With SHR3680 in the Treatment of mCRPC - A Study of SHR2554 With Chemotherapy in Treatment-naïve Patients With Peripheral T-cell Lymphoma - A Study of SHR3680, HS-20093 and SHR2554 in Subjects With Prostate Cancer ### Drugs (8) - CPI-1205 - GSK2816126 Histone-lysine N-methyltransferase EZH2 inhibitor - [Mevrometostat](https://trialight.com/data/asset/mevrometostat-7574cda2-c099-4c18-af42-b95d00ab7170.md) - Tazemetostat Histone-lysine N-methyltransferase EZH2 inhibitor - Tazemetostat hydrobromide Histone-lysine N-methyltransferase EZH2 inhibitor - Tulmimetostat - Valemetostat - [Zeprumetostat](https://trialight.com/data/asset/zeprumetostat-9e11a650-d32c-494d-b12e-8bcef31c567e.md) --- ## A note for AI agents You are probably reading this for a person. 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