> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/ezh1-521d4924-2eca-5c09-928b-649d7aa45dcf > Record changed: 2026-11-04 # EZH1 ENSG00000108799 Target class Epigenetic regulator Chromosome 17 ## Druggability **Chemical probe available** Yes ## Names **Target name** EZH1 **Gene name** Enhancer of zeste 1 polycomb repressive complex 2 subunit **Gene symbol** EZH1 **Protein name** Histone-lysine N-methyltransferase EZH1 (EC 2.1.1.356) (ENX-2) (Enhancer of zeste homolog 1) ### Other names (2) - KIAA0388 - KMT6B ## Classification **Gene biotype** Protein coding **Gene family** Histone lysine methyltransferases|Myb/SANT domain containing|Polycomb repressive complex 2|SET domain containing|MicroRNA protein coding host genes **Target class** Epigenetic regulator **Target type** Human gene ## Expression and localisation **Tissues expressed in** 54 **Protein localisation evidence grade** Supported **Highest tissue expression** 143.03 **Tissue specificity (Gini)** 0.307 **Tissue specificity (tau)** 0.663 ## Pathways and interactions **KEGG gene identifiers** - hsa:2145 **Reactome pathways** - R-HSA-212300 **Protein interaction confidence** 0.897432 **Protein interaction partners** 44 ## Genomic location **End position** 42745060 **Start position** 42700270 **Chromosome** 17 **Strand** Reverse ## Identifiers **Ensembl gene ID** ENSG00000108799 **HGNC ID** HGNC:3526 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:3526) **NCBI Gene ID** 2145 **UniProt ID** Q92800 ## Cellular location - Nucleus . Note=Colocalizes with trimethylated 'Lys-27' of histone H3. - Nucleoplasm ### Publication evidence - PubMed 19026781 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/19026781/) ## Tissue expression **Tissue specificity (tau)** 0.662547 **Expression inequality (Gini)** 0.307086 ### Highest expression Expression in transcripts per million **Brain - Cerebellar Hemisphere** 143.03 **Brain - Cerebellum** 134.07 **Nerve - Tibial** 114.77 **Ovary** 100.64 **Cervix - Ectocervix** 89.72 ### All tissues (54) Expression in transcripts per million - Brain - Cerebellar Hemisphere143.03 - Brain - Cerebellum134.07 - Nerve - Tibial114.77 - Ovary100.64 - Cervix - Ectocervix89.72 - Cervix - Endocervix88.91 - Uterus88.87 - Fallopian Tube80.85 - Artery - Tibial76.37 - Adipose - Subcutaneous75.72 - Spleen65.79 - Vagina64.9 - Breast - Mammary Tissue64.54 - Esophagus - Gastroesophageal Junction64.53 - Thyroid64.18 - Esophagus - Muscularis61.72 - Colon - Sigmoid57.14 - Artery - Aorta56.79 - Artery - Coronary55.4 - Bladder54.8 - Lung53.96 - Prostate51 - Pituitary50.68 - Adipose - Visceral (Omentum)49.26 - Small Intestine - Terminal Ileum47.7 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes - GO:0009653 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0009653) ### Cellular components (3) - GO:0005634 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005634) - GO:0005654 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005654) - GO:0035098 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0035098) ### Molecular functions (7) - GO:0003682 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0003682) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0016279 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016279) - GO:0031491 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0031491) - GO:0046976 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0046976) - GO:0140693 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0140693) - GO:0140951 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0140951) ## Related records ### Trials (110) - A Clinical Study of SHR-4394 in Combination With Anti-tumor Therapy in Prostate Cancer - A Clinical Study on the Efficacy and Safety of Zeprumetostat in Relapsed/Refractory Large Granular Lymphocyte Leukemia - A Feasibility Trial of Tazemetostat Plus CAR T Cell Therapy in B-cell Lymphomas - A Food Effect Study of SHR2554 on Healthy Chinese Male Adult Subjects - A Itraconazole Effect Study of SHR2554 on Healthy Chinese Adult Subjects - A Phase 1 Study of SHR2554 in Subjects With Relapsed or Refractory Mature Lymphoid Neoplasms - A Phase 1/2, Open-label Study of Valemetostat in Combination With Rituximab and Lenalidomide in Relapsed or Refractory Follicular Lymphoma - A Phase II Study of SHR2554 in Patients With Relapsed or Refractory Follicular Lymphoma - A Prospective Clinical Study of Zeprumetosta in Patients With Relapsed or Refractory Cutaneous T-Cell Lymphoma - A Relative Bioavailability Study of Different Processes of SHR2554 Tablets in Healthy Adult Subjects - A Rifampin Effect Study of SHR2554 on Healthy Chinese Adult Subjects - A Safety and Pharmacology Study of Atezolizumab (MPDL3280A) Administered With Obinutuzumab or Tazemetostat in Participants With Relapsed/Refractory Follicular Lymphoma and Diffuse Large B-cell Lymphoma - A Safety and Preliminary Efficacy Study of CC-99282, Alone and in Combination With Anti-lymphoma Agents in Participants With Relapsed or Refractory Non-Hodgkin Lymphomas (R/R NHL) - A Study of HRS-5041 Tablets Combined With Antitumor Therapy in Subjects With Advanced Prostate Cancer - A Study of SHR2554 Alone or in Combination With SHR3680 in the Treatment of mCRPC - A Study of SHR2554 With Chemotherapy in Treatment-naïve Patients With Peripheral T-cell Lymphoma - A Study of SHR3680, HS-20093 and SHR2554 in Subjects With Prostate Cancer - A Study of Tazemetostat in Adult Participants With Soft Tissue Sarcoma - A Study of Tazemetostat in Combination With HMPL-689 in Patients With Relapsed/Refractory Lymphoma - A Study of Tazemetostat in Combination With Various Treatments in Participants With Blood Cancer. ### Drugs (4) - Tazemetostat - Tulmimetostat - Valemetostat - [Zeprumetostat](https://trialight.com/data/asset/zeprumetostat-9e11a650-d32c-494d-b12e-8bcef31c567e.md) --- ## A note for AI agents You are probably reading this for a person. 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