> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/esr2-3e669f23-0238-54c8-a6ae-0a2fc6dabdfa > Record changed: 2026-11-04 # ESR2 ENSG00000140009 Target class Nuclear receptor Chromosome 14 Approved drugs 17 Clinical candidates (approved and in development) 32 ## Clinical evidence **Approved drugs** 17 **Clinical candidates (approved and in development)** 32 ## Druggability **Chemical probe available** Yes ## Names **Target name** ESR2 **Gene name** Estrogen receptor 2 **Gene symbol** ESR2 **Protein name** Estrogen receptor beta (ER-beta) (Nuclear receptor subfamily 3 group A member 2) ### Other names (3) - NR3A2 - Erb - ER-beta ## Classification **Gene biotype** Protein coding **Gene family** Estrogen receptors **Target class** Nuclear receptor **Target type** Human gene ## Expression and localisation **Tissues expressed in** 10 **Protein localisation evidence grade** Supported **Highest tissue expression** 4.63 **Tissue specificity (Gini)** 0.561 **Tissue specificity (tau)** 0.869 ## Pathways and interactions **KEGG gene identifiers** - hsa:2100 **Protein interaction confidence** 0.871153 **Protein interaction partners** 59 ### Reactome pathways (6) - R-HSA-1257604 - R-HSA-2219530 - R-HSA-383280 - R-HSA-6811558 - R-HSA-8939211 - R-HSA-9009391 ## Genomic location **End position** 64338112 **Start position** 64084232 **Chromosome** 14 **Strand** Reverse ## Identifiers **Ensembl gene ID** ENSG00000140009 **HGNC ID** HGNC:3468 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:3468) **NCBI Gene ID** 2100 **UniProt ID** Q92731 ## Cellular location - Nucleus . - Nucleoplasm ### Publication evidence (2) - PubMed 19126643 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/19126643/) - PubMed 20074560 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/20074560/) ## Tissue expression **Tissue specificity (tau)** 0.86878 **Expression inequality (Gini)** 0.561222 ### Highest expression Expression in transcripts per million **Ovary** 4.63 **Testis** 3.85 **Adrenal Gland** 3.56 **Cells - EBV-transformed lymphocytes** 2.26 **Cervix - Endocervix** 1.4 ### All tissues (54) Expression in transcripts per million - Ovary4.63 - Testis3.85 - Adrenal Gland3.56 - Cells - EBV-transformed lymphocytes2.26 - Cervix - Endocervix1.4 - Spleen1.26 - Prostate1.08 - Kidney - Medulla1.08 - Uterus1.08 - Fallopian Tube1.06 - Adipose - Subcutaneous0.83 - Pituitary0.79 - Breast - Mammary Tissue0.73 - Thyroid0.68 - Small Intestine - Terminal Ileum0.68 - Brain - Cerebellum0.66 - Skin - Not Sun Exposed (Suprapubic)0.63 - Lung0.62 - Cervix - Ectocervix0.62 - Minor Salivary Gland0.61 - Adipose - Visceral (Omentum)0.61 - Brain - Cerebellar Hemisphere0.61 - Kidney - Cortex0.56 - Bladder0.54 - Nerve - Tibial0.53 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (6) - GO:0000122 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0000122) - GO:0006355 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006355) - GO:0007165 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007165) - GO:0007267 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007267) - GO:0030520 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030520) - GO:0045893 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045893) ### Cellular components (3) - GO:0005634 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005634) - GO:0005654 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005654) - GO:0005739 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005739) ### Molecular functions (9) - GO:0000978 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0000978) - GO:0003677 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0003677) - GO:0003707 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0003707) - GO:0004879 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004879) - GO:0005496 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005496) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0019899 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0019899) - GO:0030284 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030284) - GO:0034056 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0034056) ## Off-target safety - regulation of transcription factor activity ### Studies (3) - cell-based: TOX21\_ERb\_BLA\_Agonist\_ratio is an assay readout measuring reporter gene via receptor activity and designed using inducible reporter (beta lactamase induction) detected with GAL4 b-lactamase reporter gene. The signal is derived from the ratio of cleaved (ch2) to uncleaved (ch1) reporter gene substrate used as the measure of target activity. - cell-based: TOX21\_ERb\_BLA\_Antagonist\_ratio is an assay readout measuring reporter gene via receptor activity and designed using inducible reporter (beta lactamase induction) detected with GAL4 b-lactamase reporter gene. The signal is derived from the ratio of cleaved (ch2) to uncleaved (ch1) reporter gene substrate used as the measure of target activity. - cell-based ### Biological samples (2) - HEK293T, cell line - HepG2, cell line Evidence source Source: [www.epa.gov](https://www.epa.gov/chemical-research/exploring-toxcast-data-downloadable-data) - protein stabilization ### Studies (4) - cell-based: OT\_ER\_ERbERb\_0480, is one of one assay component(s) measured or calculated from the OT\_ER\_ERbERb\_0480 assay. It is designed to make measurements of protein fragment complementation, a form of binding reporter, as detected with fluorescence intensity signals by Protein-fragment Complementation technology. - cell-based: OT\_ER\_ERbERb\_1440, is one of one assay component(s) measured or calculated from the OT\_ER\_ERbERb\_1440 assay. It is designed to make measurements of protein fragment complementation, a form of binding reporter, as detected with fluorescence intensity signals by Protein-fragment Complementation technology. - cell-based: OT\_ER\_ERaERb\_1440, is one of one assay component(s) measured or calculated from the OT\_ER\_ERaERb\_1440 assay. It is designed to make measurements of protein fragment complementation, a form of binding reporter, as detected with fluorescence intensity signals by Protein-fragment Complementation technology. - cell-based: OT\_ER\_ERaERb\_0480, is one of one assay component(s) measured or calculated from the OT\_ER\_ERaERb\_0480 assay. It is designed to make measurements of protein fragment complementation, a form of binding reporter, as detected with fluorescence intensity signals by Protein-fragment Complementation technology. ### Biological samples - HEK293T, cell line Evidence source Source: [www.epa.gov](https://www.epa.gov/chemical-research/exploring-toxcast-data-downloadable-data) - regulation of steroid biosynthetic process ### Studies (4) - cell-based: CEETOX\_H295R\_ESTRONE, is one of 23 assay component(s) measured or calculated from the CEETOX\_H295R assay. It is designed to make measurements of hormone induction, a form of inducible reporter, as detected with absorbance signals by HPLC-MS-MS technology. - cell-based: CEETOX\_H295R\_ESTRADIOL, is one of 23 assay component(s) measured or calculated from the CEETOX\_H295R assay. It is designed to make measurements of hormone induction, a form of inducible reporter, as detected with absorbance signals by HPLC-MS-MS technology. - cell-based: CEETOX\_H295R\_ESTRADIOL, is one of 23 assay component(s) measured or calculated from the CEETOX\_H295R assay. It is designed to make measurements of hormone induction, a form of inducible reporter, as detected with absorbance signals by HPLC-MS-MS technology. - cell-based: CEETOX\_H295R\_ESTRONE, is one of 23 assay component(s) measured or calculated from the CEETOX\_H295R assay. It is designed to make measurements of hormone induction, a form of inducible reporter, as detected with absorbance signals by HPLC-MS-MS technology. ### Biological samples - H295R, cell line Evidence source Source: [www.epa.gov](https://www.epa.gov/chemical-research/exploring-toxcast-data-downloadable-data) - regulation of steroid hormone biosynthetic process ### Studies (5) - cell-based: one of 12 assay component(s) measured or calculated from the CEETOX\_H295R assay (11 hormones and 1 viability assay). It is designed to make measurements of hormone induction, a form of inducible reporter, as detected with absorbance signals by HPLC-MS-MS technology. The concentrations for these components have not been pre-filtered for the maximum tolerated concentration (MTC) based on the MTT assay (\_noMTC). - cell-based: one of 12 assay component(s) measured or calculated from the CEETOX\_H295R assay (11 hormones and 1 viability assay). It is designed to make measurements of hormone induction, a form of inducible reporter, as detected with absorbance signals by HPLC-MS-MS technology. The concentrations for these components have not been pre-filtered for the maximum tolerated concentration (MTC) based on the MTT assay (\_noMTC). - cell-based: one of 12 assay component(s) measured or calculated from the CEETOX\_H295R assay (11 hormones and 1 viability assay). It is designed to make measurements of hormone induction, a form of inducible reporter, as detected with absorbance signals by HPLC-MS-MS technology. The concentrations for these components have not been pre-filtered for the maximum tolerated concentration (MTC) based on the MTT assay (\_noMTC). - cell-based: one of 12 assay component(s) measured or calculated from the CEETOX\_H295R assay (11 hormones and 1 viability assay). It is designed to make measurements of hormone induction, a form of inducible reporter, as detected with absorbance signals by HPLC-MS-MS technology. The concentrations for these components have not been pre-filtered for the maximum tolerated concentration (MTC) based on the MTT assay (\_noMTC). - cell-based: one of 12 assay component(s) measured or calculated from the CEETOX\_H295R assay (11 hormones and 1 viability assay). It is designed to make measurements of hormone induction, a form of inducible reporter, as detected with absorbance signals by HPLC-MS-MS technology. The concentrations for these components have not been pre-filtered for the maximum tolerated concentration (MTC) based on the MTT assay (\_noMTC). ### Biological samples - H295R, cell line Evidence source Source: [www.epa.gov](https://www.epa.gov/chemical-research/exploring-toxcast-data-downloadable-data) ## Related records ### Trials (1,718) - "Effect of CPA/EE Drug on Periodontal Tissue and hsCRP Levels in PCOS Patients With Gingivitis - "Neo-Adjuvant Treatment With Palbociclib: Effect on Ki67 and Apoptosis Before, During and After Treatment " - "Quick-starting" of a New Combined Hormonal Contraceptive Pills, 15 mg Estetrol/3 mg Drospirenone VS 20 mcg Ethinylestradiol/75 mcg Gestodene Focusing on Ovulation Inhibition - "Quick-starting" of a Quadriphasic Contraceptive Pills, 1 - 3 mg Estradiol Valerate/ 2 - 3 mg Dienogest VS 20 mcg Ethinylestradiol/75 mcg Gestodene Focusing on Ovulation Inhibition - (VELA) Study of BLU-222 in Advanced Solid Tumors - (Z)-Endoxifen for the Treatment of Premenopausal Women With ER+/HER2- Breast Cancer - (Z)-Endoxifen in Girls With MAS-Associated Peripheral Precocious Puberty - \[177Lu\]Lu-NeoB in Combination With Ribociclib and Fulvestrant in Participants With ER+, HER2- and GRPR+ Advanced Breast Cancer - 2-Year Therapy With Teriparatide vs 1-yr Therapy Followed by 1-Year of Raloxifene or Calcium/Vit D in Severe Postmenopausal Osteoporosis - 3-year Study of Menostar Versus Evista to Prevent Osteoporosis in Post-menopausal Women - 4-Hydroxytamoxifen or Tamoxifen Citrate in Treating Women With Newly Diagnosed Ductal Breast Carcinoma in Situ - A Bioequivalence Study of Norgestimate /Ethinyl Estradiol (NGM/EE) Tablets Manufactured at 2 Different Facilities - A Biomarker Study of Palbociclib + Fulvestrant for Second, and Third Line of Postmenopausal Women With hr+/her2- Advanced Breast Cancer - A Chemoprevention Study of an Investigational Drug in Men With High Grade Prostate Intraepithelial Neoplasia (PIN) - [A Clinical Study of JS105 in Combination With Other Anti-tumor Therapies in Patients With Solid Tumors](https://trialight.com/data/trial/a-clinical-study-of-js105-in-combination-with-other-anti-a416fdf1-1a18-433c-aa31-f3b60bad7915.md) - A Clinical Study on Yasmin® vs. Marvelon® in Chinese Women Requiring Contraception - A Clinical Study to Evaluate Ospemifene in the Treatment of Vulvar and Vaginal Atrophy in Postmenopausal Women - A Clinical Study to Evaluate the Effects of Estrogen in Healthy Postmenopausal Women - A Clinical Study to Evaluate the Efficacy and Safety of Ospemifene in the Treatment of Vulvar and Vaginal Atrophy (VVA) in Postmenopausal Women - A Clinical Study to Evaluate the Safety and Efficacy of Elagolix in Participants With Moderate to Severe Endometriosis-Associated Pain ### Drugs (48) - Acolbifene Estrogen receptor modulator - Acolbifene hydrochloride Estrogen receptor modulator - Afimoxifene Estrogen receptor modulator - Allylestrenol Estrogen receptor agonist - Arzoxifene Estrogen receptor modulator - Arzoxifene hydrochloride Estrogen receptor modulator - AUS-131 Estrogen receptor beta agonist - Bazedoxifene Estrogen receptor modulator - Bazedoxifene acetate Estrogen receptor modulator - CHF4227 Estrogen receptor modulator - Chlorotrianisene Estrogen receptor beta modulator - CR 1447 Estrogen receptor beta agonist - Cyclofenil Estrogen receptor modulator - Diethylstilbestrol - Diethylstilbestrol diphosphate Estrogen receptor agonist - Droloxifene Estrogen receptor modulator - Droloxifene citrate Estrogen receptor modulator - Erteberel Estrogen receptor beta agonist - Estetrol Estrogen receptor agonist - Estetrol anhydrous Estrogen receptor agonist --- ## A note for AI agents You are probably reading this for a person. 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