ESR2

ENSG00000140009
Target class
Nuclear receptor
Chromosome
14
Approved drugs
17
Clinical candidates (approved and in development)
32

Approved drugs
17
Clinical candidates (approved and in development)
32

Chemical probe available
Yes

Target name
ESR2
Gene name
Estrogen receptor 2
Gene symbol
ESR2
Protein name
Estrogen receptor beta (ER-beta) (Nuclear receptor subfamily 3 group A member 2)

  • NR3A2
  • Erb
  • ER-beta

Gene biotype
Protein coding
Gene family
Estrogen receptors
Target class
Nuclear receptor
Target type
Human gene

Tissues expressed in
10
Protein localisation evidence grade
Supported
Highest tissue expression
4.63
Tissue specificity (Gini)
0.561
Tissue specificity (tau)
0.869

KEGG gene identifiers
  • hsa:2100
Protein interaction confidence
0.871153
Protein interaction partners
59

  • R-HSA-1257604
  • R-HSA-2219530
  • R-HSA-383280
  • R-HSA-6811558
  • R-HSA-8939211
  • R-HSA-9009391

End position
64338112
Start position
64084232
Chromosome
14
Strand
Reverse

Ensembl gene ID
ENSG00000140009
HGNC ID
HGNC:3468
www.genenames.org
NCBI Gene ID
2100
UniProt ID
Q92731

  • Nucleus .
  • Nucleoplasm

Tissue specificity (tau)
0.86878
Expression inequality (Gini)
0.561222

Expression in transcripts per million

Ovary
4.63
Testis
3.85
Adrenal Gland
3.56
Cells - EBV-transformed lymphocytes
2.26
Cervix - Endocervix
1.4

Expression in transcripts per million

  • Ovary4.63
  • Testis3.85
  • Adrenal Gland3.56
  • Cells - EBV-transformed lymphocytes2.26
  • Cervix - Endocervix1.4
  • Spleen1.26
  • Prostate1.08
  • Kidney - Medulla1.08
  • Uterus1.08
  • Fallopian Tube1.06
  • Adipose - Subcutaneous0.83
  • Pituitary0.79
  • Breast - Mammary Tissue0.73
  • Thyroid0.68
  • Small Intestine - Terminal Ileum0.68
  • Brain - Cerebellum0.66
  • Skin - Not Sun Exposed (Suprapubic)0.63
  • Lung0.62
  • Cervix - Ectocervix0.62
  • Minor Salivary Gland0.61
  • Adipose - Visceral (Omentum)0.61
  • Brain - Cerebellar Hemisphere0.61
  • Kidney - Cortex0.56
  • Bladder0.54
  • Nerve - Tibial0.53

And 29 more, listed on the interactive page.

  • regulation of transcription factor activity

    • cell-based: TOX21_ERb_BLA_Agonist_ratio is an assay readout measuring reporter gene via receptor activity and designed using inducible reporter (beta lactamase induction) detected with GAL4 b-lactamase reporter gene. The signal is derived from the ratio of cleaved (ch2) to uncleaved (ch1) reporter gene substrate used as the measure of target activity.
    • cell-based: TOX21_ERb_BLA_Antagonist_ratio is an assay readout measuring reporter gene via receptor activity and designed using inducible reporter (beta lactamase induction) detected with GAL4 b-lactamase reporter gene. The signal is derived from the ratio of cleaved (ch2) to uncleaved (ch1) reporter gene substrate used as the measure of target activity.
    • cell-based

    • HEK293T, cell line
    • HepG2, cell line
    Evidence source
    www.epa.gov

  • protein stabilization

    • cell-based: OT_ER_ERbERb_0480, is one of one assay component(s) measured or calculated from the OT_ER_ERbERb_0480 assay. It is designed to make measurements of protein fragment complementation, a form of binding reporter, as detected with fluorescence intensity signals by Protein-fragment Complementation technology.
    • cell-based: OT_ER_ERbERb_1440, is one of one assay component(s) measured or calculated from the OT_ER_ERbERb_1440 assay. It is designed to make measurements of protein fragment complementation, a form of binding reporter, as detected with fluorescence intensity signals by Protein-fragment Complementation technology.
    • cell-based: OT_ER_ERaERb_1440, is one of one assay component(s) measured or calculated from the OT_ER_ERaERb_1440 assay. It is designed to make measurements of protein fragment complementation, a form of binding reporter, as detected with fluorescence intensity signals by Protein-fragment Complementation technology.
    • cell-based: OT_ER_ERaERb_0480, is one of one assay component(s) measured or calculated from the OT_ER_ERaERb_0480 assay. It is designed to make measurements of protein fragment complementation, a form of binding reporter, as detected with fluorescence intensity signals by Protein-fragment Complementation technology.

    Biological samples

    • HEK293T, cell line
    Evidence source
    www.epa.gov

  • regulation of steroid biosynthetic process

    • cell-based: CEETOX_H295R_ESTRONE, is one of 23 assay component(s) measured or calculated from the CEETOX_H295R assay. It is designed to make measurements of hormone induction, a form of inducible reporter, as detected with absorbance signals by HPLC-MS-MS technology.
    • cell-based: CEETOX_H295R_ESTRADIOL, is one of 23 assay component(s) measured or calculated from the CEETOX_H295R assay. It is designed to make measurements of hormone induction, a form of inducible reporter, as detected with absorbance signals by HPLC-MS-MS technology.
    • cell-based: CEETOX_H295R_ESTRADIOL, is one of 23 assay component(s) measured or calculated from the CEETOX_H295R assay. It is designed to make measurements of hormone induction, a form of inducible reporter, as detected with absorbance signals by HPLC-MS-MS technology.
    • cell-based: CEETOX_H295R_ESTRONE, is one of 23 assay component(s) measured or calculated from the CEETOX_H295R assay. It is designed to make measurements of hormone induction, a form of inducible reporter, as detected with absorbance signals by HPLC-MS-MS technology.

    Biological samples

    • H295R, cell line
    Evidence source
    www.epa.gov

  • regulation of steroid hormone biosynthetic process

    • cell-based: one of 12 assay component(s) measured or calculated from the CEETOX_H295R assay (11 hormones and 1 viability assay). It is designed to make measurements of hormone induction, a form of inducible reporter, as detected with absorbance signals by HPLC-MS-MS technology. The concentrations for these components have not been pre-filtered for the maximum tolerated concentration (MTC) based on the MTT assay (_noMTC).
    • cell-based: one of 12 assay component(s) measured or calculated from the CEETOX_H295R assay (11 hormones and 1 viability assay). It is designed to make measurements of hormone induction, a form of inducible reporter, as detected with absorbance signals by HPLC-MS-MS technology. The concentrations for these components have not been pre-filtered for the maximum tolerated concentration (MTC) based on the MTT assay (_noMTC).
    • cell-based: one of 12 assay component(s) measured or calculated from the CEETOX_H295R assay (11 hormones and 1 viability assay). It is designed to make measurements of hormone induction, a form of inducible reporter, as detected with absorbance signals by HPLC-MS-MS technology. The concentrations for these components have not been pre-filtered for the maximum tolerated concentration (MTC) based on the MTT assay (_noMTC).
    • cell-based: one of 12 assay component(s) measured or calculated from the CEETOX_H295R assay (11 hormones and 1 viability assay). It is designed to make measurements of hormone induction, a form of inducible reporter, as detected with absorbance signals by HPLC-MS-MS technology. The concentrations for these components have not been pre-filtered for the maximum tolerated concentration (MTC) based on the MTT assay (_noMTC).
    • cell-based: one of 12 assay component(s) measured or calculated from the CEETOX_H295R assay (11 hormones and 1 viability assay). It is designed to make measurements of hormone induction, a form of inducible reporter, as detected with absorbance signals by HPLC-MS-MS technology. The concentrations for these components have not been pre-filtered for the maximum tolerated concentration (MTC) based on the MTT assay (_noMTC).

    Biological samples

    • H295R, cell line
    Evidence source
    www.epa.gov

Related records

Trials (1,718)

Drugs (48)