> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/target/erbb2-900ec94b-8cc2-5864-a53d-4b5ed23c71f5
> Record changed: 2026-10-13

# ERBB2

ENSG00000141736

Target class

Kinase

Chromosome

17

Approved drugs

16

Clinical candidates (approved and in development)

46

## Clinical evidence

**Approved drugs**

16

**Clinical candidates (approved and in development)**

46

## Druggability

**Chemical probe available**

Yes

## Names

**Target name**

ERBB2

**Gene name**

Erb-b2 receptor tyrosine kinase 2

**Gene symbol**

ERBB2

**Previous gene symbols**

- NGL

**Protein name**

Receptor tyrosine-protein kinase erbB-2 (EC 2.7.10.1) (Metastatic lymph node gene 19 protein) (MLN 19) (Proto-oncogene Neu) (Proto-oncogene c-ErbB-2) (Tyrosine kinase-type cell surface receptor HER2) (p185erbB2) (CD antigen CD340)

### Other names (8)

- NEU
- HER-2
- CD340
- HER2
- c-ERB2
- c-ERB-2
- MLN-19
- p185(erbB2)

## Classification

**Gene biotype**

Protein coding

**Gene family**

CD molecules|Minor histocompatibility antigens|Erb-b2 receptor tyrosine kinases|MicroRNA protein coding host genes

**Target class**

Kinase

**Target type**

Human gene

## Expression and localisation

**Tissues expressed in**

54

**Protein localisation evidence grade**

Enhanced

**Highest tissue expression**

130.13

**Tissue specificity (Gini)**

0.484

**Tissue specificity (tau)**

0.722

## Pathways and interactions

**KEGG gene identifiers**

- hsa:2064

**Protein interaction confidence**

0.834219

**Protein interaction partners**

219

### Reactome pathways (33)

- R-HSA-1227986
- R-HSA-1250196
- R-HSA-1251932
- R-HSA-1257604
- R-HSA-1306955
- R-HSA-1358803
- R-HSA-1963640
- R-HSA-1963642
- R-HSA-2219530
- R-HSA-416572
- R-HSA-5673001
- R-HSA-6785631
- R-HSA-6811558
- R-HSA-8847993
- R-HSA-8863795
- R-HSA-8866910
- R-HSA-9634285
- R-HSA-9652282
- R-HSA-9664565
- R-HSA-9665233
- R-HSA-9665244
- R-HSA-9665245
- R-HSA-9665246
- R-HSA-9665247
- R-HSA-9665249

And 8 more, listed on the interactive page.

## Genomic location

**End position**

39730426

**Start position**

39687914

**Chromosome**

17

**Strand**

Forward

## Identifiers

**Ensembl gene ID**

ENSG00000141736

**HGNC ID**

HGNC:3430

Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:3430)

**NCBI Gene ID**

2064

**UniProt ID**

P04626

## Cellular location

- Cell membrane
- Single-pass type I membrane protein . Cell projection, ruffle membrane
- Single-pass type I membrane protein . Note=Internalized from the cell membrane in response to EGF stimulation. .
- SUBCELLULAR LOCATION: \[Isoform 1\]: Cell membrane
- Single-pass type I membrane protein . Early endosome . Cytoplasm, perinuclear region. Nucleus. Note=Translocation to the nucleus requires endocytosis, probably endosomal sorting and is mediated by importin beta-1/KPNB1\. Also detected in VPS35-positive endosome-to-TGN retrograde vesicles (PubMed:31138794). .
- SUBCELLULAR LOCATION: \[Isoform 2\]: Cytoplasm. Nucleus.
- SUBCELLULAR LOCATION: \[Isoform 3\]: Cytoplasm. Nucleus.
- Cytosol
- Nucleoplasm
- Plasma membrane

### Publication evidence (4)

- PubMed 32381043  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/32381043/)
- PubMed 34380438  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/34380438/)
- PubMed 31138794  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/31138794/)
- PubMed 33497358  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/33497358/)

## Tissue expression

**Tissue specificity (tau)**

0.722458

**Expression inequality (Gini)**

0.484421

### Highest expression

Expression in transcripts per million

**Nerve - Tibial**

130.13

**Skin - Sun Exposed (Lower leg)**

118.26

**Esophagus - Mucosa**

113.1

**Skin - Not Sun Exposed (Suprapubic)**

110.94

**Thyroid**

99.31

### All tissues (54)

Expression in transcripts per million

- Nerve - Tibial130.13
- Skin - Sun Exposed (Lower leg)118.26
- Esophagus - Mucosa113.1
- Skin - Not Sun Exposed (Suprapubic)110.94
- Thyroid99.31
- Artery - Aorta84.45
- Minor Salivary Gland83.83
- Prostate83.77
- Vagina78.81
- Artery - Tibial65.22
- Kidney - Medulla64.82
- Cervix - Ectocervix60.61
- Artery - Coronary55.06
- Kidney - Cortex53.57
- Colon - Transverse51.18
- Cervix - Endocervix50.03
- Uterus48.03
- Fallopian Tube47.86
- Lung47.78
- Small Intestine - Terminal Ileum44.18
- Ovary38.72
- Heart - Atrial Appendage38.38
- Breast - Mammary Tissue36.91
- Bladder36.5
- Cells - Cultured fibroblasts36.22

And 29 more, listed on the interactive page.

## Biological functions

### Biological processes (22)

- GO:0006468  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006468)
- GO:0007165  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007165)
- GO:0007166  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007166)
- GO:0007167  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007167)
- GO:0007169  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007169)
- GO:0008283  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008283)
- GO:0018108  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0018108)
- GO:0030307  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030307)
- GO:0032886  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032886)
- GO:0035556  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0035556)
- GO:0038134  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0038134)
- GO:0042060  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042060)
- GO:0043406  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043406)
- GO:0043491  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043491)
- GO:0045727  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045727)
- GO:0045785  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045785)
- GO:0045943  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045943)
- GO:0050679  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0050679)
- GO:0070372  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070372)
- GO:0071363  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0071363)
- GO:0071364  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0071364)
- GO:0090314  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0090314)

### Cellular components (9)

- GO:0005634  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005634)
- GO:0005654  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005654)
- GO:0005769  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005769)
- GO:0005829  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005829)
- GO:0005886  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886)
- GO:0010008  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0010008)
- GO:0016323  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016323)
- GO:0038143  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0038143)
- GO:0043235  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043235)

### Molecular functions (11)

- GO:0001042  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0001042)
- GO:0004713  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004713)
- GO:0004714  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004714)
- GO:0004888  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004888)
- GO:0005102  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005102)
- GO:0005515  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515)
- GO:0019838  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0019838)
- GO:0030971  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030971)
- GO:0042802  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042802)
- GO:0043125  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043125)
- GO:0046982  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0046982)

## On-target safety

- heart disease  
### Studies

  - preclinical: Important for the heart and vasculature based on findings in genetically modified or kinase-inhibitor-treated mice. Role of kinase in heart/vasculature: Cardiomyocyte survival and homeostasis; maintenance of left ventricular function  
### Biological samples

  - cardiovascular system  
PubMed 21283106  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/21283106/)

## Related records

### Trials (2,542)

- -02341066 and PF-00299804 for Advanced Non-Small Cell Lung Cancer
- "Neo-Adjuvant Treatment With Palbociclib: Effect on Ki67 and Apoptosis Before, During and After Treatment "
- "Phase II Study of PET Guided Neoadjuvant Chemotherapy (NAC) and Oncotype Guided Hormonal Therapy of Breast Cancer"
- 12 weekS Adjuvant dOcetaxel Plus trastuzumaB in Patients With Small, Node-negative, HER2-positive Breast cancER (SOBER)
- 1303GCC: Trastuzmab & Pertuzumab With Hormonal Therapy or Chemotherapy in Women Aged 60 and Over.
- 18F-FDG Uptake Heterogeneity Predicts Pyrotinib Response
- 4-1BB Agonist Monoclonal Antibody PF-05082566 With Trastuzumab Emtansine or Trastuzumab in Treating Patients With Advanced HER2-Positive Breast Cancer
- 6 Weeks Treatment of Locally Advanced Breast Cancer With BIBW 2992 (Afatinib) or Lapatinib or Trastuzumab
- 64-Cu Labeled Brain PET/MRI for MM-302 in Advanced HER2+ Cancers With Brain Mets
- 89Zr-Trastuzumab PET/CT in Subjects With Previously Treated HER2-Positive Solid Tumors Scheduled to Receive Treatment With MT-5111
- 89ZrTrastuzumab Breast Imaging With Positron Emission Tomography
- A 1-year Multi-center, Prospective, Cohort Study in Patients With Chronic Obstructive Pulmonary Disease Treated With Long-acting Bronchodilator
- A Bioavailability Study of GS1-144 Tablets in Healthy Postmenopausal Women
- A Bioavailability Study of Two Different PEG-rhGH Preparations.
- A Bioequivalence Study of Two Different PEG-rhGH Preparations
- A Bioequivalence Study of Two Different PEG-rhGH Preparations.
- A Bioequivalence Study of Two Different Processes of PEG-rhGH Preparations
- A Biomarker-implemented Clinical Study Evaluating Mutations in MET and TP53 in a Population of Treatment-refractory Squamous Cell Carcinoma
- A Clinica Study of Pyrotinib in Patients of Advanced Non-Small Cell Lung Cancer With HER2 Mutation
- A Clinical Study Comparing Anti-HER2 Therapy Combined With Chemotherapy to Chemotherapy Alone as Adjuvant Therapy Following Surgery for Stage IB-II Gastric Cancer With High HER2 Expression.

### Drugs (50)

- AC-480 Receptor protein-tyrosine kinase erbB-2 inhibitor
- AEE-788 Receptor protein-tyrosine kinase erbB-2 inhibitor
- Afatinib Receptor protein-tyrosine kinase erbB-2 inhibitor
- Afatinib dimaleate Receptor protein-tyrosine kinase erbB-2 inhibitor
- Allitinib Receptor protein-tyrosine kinase erbB-2 inhibitor
- Anvatabart opadotin Receptor protein-tyrosine kinase erbB-2 binding agent
- AV-412 Receptor protein-tyrosine kinase erbB-2 inhibitor
- AV-412 FREE BASE Receptor protein-tyrosine kinase erbB-2 inhibitor
- BMS-690514 Receptor protein-tyrosine kinase erbB-2 inhibitor
- Canertinib Receptor protein-tyrosine kinase erbB-2 inhibitor
- Canertinib dihydrochloride Receptor protein-tyrosine kinase erbB-2 inhibitor
- CP-724714 Receptor protein-tyrosine kinase erbB-2 inhibitor
- CUDC-101 Receptor protein-tyrosine kinase erbB-2 inhibitor
- Dacomitinib Receptor protein-tyrosine kinase erbB-2 inhibitor
- Dacomitinib anhydrous Receptor protein-tyrosine kinase erbB-2 inhibitor
- [Disitamab vedotin](https://trialight.com/data/asset/disitamab-vedotin-bea2e0f0-afc7-4495-83ca-87eaf4660054.md) Receptor tyrosine-protein kinase erbB-2 binding agent
- Ertumaxomab Receptor protein-tyrosine kinase erbB-2 cross-linking agent
- Gancotamab Receptor protein-tyrosine kinase erbB-2 binding agent
- Hemay-022 Receptor protein-tyrosine kinase erbB-2 inhibitor
- JNJ-26483327 Receptor protein-tyrosine kinase erbB-2 inhibitor

---

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