> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/target/ephx2-16b07d0c-ffff-5102-a1a0-00bed49a4b0f
> Record changed: 2026-11-04

# EPHX2

ENSG00000120915

Target class

Enzyme

Chromosome

8

Approved drugs

0

Clinical candidates (approved and in development)

2

## Clinical evidence

**Approved drugs**

0

**Clinical candidates (approved and in development)**

2

## Druggability

**Chemical probe available**

Yes

## Names

**Target name**

EPHX2

**Gene name**

Epoxide hydrolase 2

**Gene symbol**

EPHX2

**Protein name**

Bifunctional epoxide hydrolase 2 \[Includes: Cytosolic epoxide hydrolase 2 (CEH) (EC 3.3.2.10) (Epoxide hydratase) (Soluble epoxide hydrolase) (SEH); Lipid-phosphate phosphatase (EC 3.1.3.76)\]

### Other names (2)

- ABHD20
- sEH

## Classification

**Gene biotype**

Protein coding

**Gene family**

Abhydrolase domain containing|HAD Asp-based non-protein phosphatases

**Target class**

Enzyme

**Target type**

Human gene

## Expression and localisation

**Tissues expressed in**

54

**Protein localisation evidence grade**

Enhanced

**Highest tissue expression**

86.54

**Tissue specificity (Gini)**

0.391

**Tissue specificity (tau)**

0.763

## Pathways and interactions

**KEGG gene identifiers**

- hsa:2053

**Protein interaction confidence**

0.829038

**Protein interaction partners**

52

### Reactome pathways (3)

- R-HSA-2142670
- R-HSA-9018682
- R-HSA-9033241

## Genomic location

**End position**

27548992

**Start position**

27490775

**Chromosome**

8

**Strand**

Forward

## Identifiers

**Ensembl gene ID**

ENSG00000120915

**HGNC ID**

HGNC:3402

Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:3402)

**NCBI Gene ID**

2053

**UniProt ID**

P34913

## Cellular location

- Cytoplasm. Peroxisome.
- Cytosol

## Tissue expression

**Tissue specificity (tau)**

0.763248

**Expression inequality (Gini)**

0.391403

### Highest expression

Expression in transcripts per million

**Liver**

86.54

**Adrenal Gland**

61.99

**Kidney - Medulla**

53.04

**Prostate**

48.99

**Pituitary**

44.91

### All tissues (54)

Expression in transcripts per million

- Liver86.54
- Adrenal Gland61.99
- Kidney - Medulla53.04
- Prostate48.99
- Pituitary44.91
- Ovary40.8
- Small Intestine - Terminal Ileum40.02
- Kidney - Cortex39.55
- Skin - Not Sun Exposed (Suprapubic)38.99
- Skin - Sun Exposed (Lower leg)37.46
- Colon - Transverse35.68
- Fallopian Tube33.82
- Esophagus - Mucosa31.97
- Cervix - Ectocervix28.94
- Cervix - Endocervix28.74
- Uterus27.59
- Thyroid27.08
- Vagina26.36
- Colon - Sigmoid25.93
- Bladder23.51
- Pancreas23.17
- Breast - Mammary Tissue21.49
- Esophagus - Gastroesophageal Junction18.55
- Minor Salivary Gland17.4
- Esophagus - Muscularis17.01

And 29 more, listed on the interactive page.

## Biological functions

### Biological processes (8)

- GO:0001558  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0001558)
- GO:0010628  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0010628)
- GO:0016311  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016311)
- GO:0042632  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042632)
- GO:0046272  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0046272)
- GO:0046839  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0046839)
- GO:0090181  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0090181)
- GO:0097176  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0097176)

### Cellular components (4)

- GO:0005777  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005777)
- GO:0005782  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005782)
- GO:0005829  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005829)
- GO:0070062  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070062)

### Molecular functions (8)

- GO:0000287  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0000287)
- GO:0004301  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004301)
- GO:0015643  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0015643)
- GO:0016791  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016791)
- GO:0033885  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0033885)
- GO:0042577  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042577)
- GO:0042803  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042803)
- GO:0052642  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0052642)

## Related records

### Trials (305)

- "Thymalfasin Immunotherapy Study with Triple Regimen in Advanced MSS/pMMR Colorectal Cancer"
- (VOYAGER) Study of Avapritinib vs Regorafenib in Patients With Locally Advanced Unresectable or Metastatic GIST
- \[18F\]FLT-PET as a Predictive Imaging Biomaker of Treatment Responses to Regorafenib
- 5-Fluorouracil/Leucovorin (5FU/LV) in Combination With Regorafenib in Patients With Metastatic Colorectal Cancer
- A Biomarker Study in Patients Getting Regorafenib for Metastatic Colorectal Cancer
- A Clincal Study of Max-40279-01 in Patients With Advanced Colorectal Cancer
- A Clinical Study of BioTTT001 in Combination With Toripalimab and Regorafenib in Patients With Colorectal Cancer
- A Clinical Study of Regorafenib in Participants Who Have Been Treated in Previous Bayer-sponsored Regorafenib Studies That Have Been Completed
- A Clinical Study of SH006 Injection in Combination Therapy Versus Regorafenib in the Treatment of Advanced Hepatocellular Carcinoma
- A Clinical Study of T3011 in Combination With Regorafenib in Patients With Advanced Colorectal Cancer
- A Clinical Study of T3011 in Combination With Toripalimab and Regorafenib in Patients With Colorectal Cancer
- A Clinical Study to Evaluate Injection TQB2102 for the Treatment of Patients With HER2 IHC3+ Advanced Colorectal Cancer Who Progressed After Treatment With Oxaliplatin, Irinotecan and Fluoropyrimidine-Based Drugs
- A Clinical Trial of Regorafenib in Patients With Pretreated Advanced Melanoma
- A Phase 2 Randomized, Open-Label Study of RRx-001 vs Regorafenib in Subjects With Metastatic Colorectal Cancer
- A Phase 2 Trial of Regorafenib as A Single Agent in Advanced and Metastatic Biliary Tract Carcinoma/Cholangiocarcinoma Patients Who Have Failed First-line Chemotherapy
- A Phase 4 Study of Regorafenib in Metastatic Colorectal Cancer - Does Educating Physicians Change Patient Outcomes?
- A Phase I Dose Finding Study in Children With Solid Tumors Recurrent or Refractory to Standard Therapy
- A Phase I/II Study of Regorafenib Plus Avelumab in Solid Tumors
- A Phase Ib/II Study of SYS6090 Combination Therapy in Advanced Colorectal Cancer
- A Phase II Study Evaluating Efficacy and Safety of Regorafenib in Patients With Metastatic Bone Sarcomas

### Drugs (5)

- AR9281 Epoxide hydratase inhibitor
- GSK2256294 Epoxide hydratase inhibitor
- Oxaprozin
- [Regorafenib](https://trialight.com/data/asset/regorafenib-333c1c36-b89a-41d5-b39e-bcec7346fe94.md)
- Zafirlukast

---

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